Selenoprotein evolution: introduction
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Introduction to selenoprotein evolution
(more selenoprotein classes shortly)
SEPP2: lost in placentals
SEPP2 is a newly discovered paralog of SEPP1 with a UxxC motif (plus a later conserved cysteine and distal CxxC motif) and high-scoring putative SECIS element in 3' UTR that is quite conserved in vertebrates but only through marsupials. No corresponding gene -- or even decayed debris -- can be found in syntentic position in any placental mammal, including Atlantogenata. Also, cysteine has displaced the selenocysteine in Xenopus, a species much depleted in selenoproteins. SEPP2 does not appear at GenBank non-redundant other than mis-annotated SEPP1 chicken mRNAs. SEPP2 transcripts are available only in skate, zebrafish, and echidna (a short 454 read) .
The two paralogs have 4 coding exons with identical intron phases so clearly represent a segmental gene duplication. The gene duplication can be tracked back to before chondricthyes divergence but only one copy can be located in earlier diverging deuterostomes (sea urchin and acorn worm). SEPP2 retains the selenocysteine TGA only in its first exon and lacks the cluster of them in exon 4 of SEPP1. Exon 4 in SEPP2 is diverging very rapidlly, about neutrally, and is difficult to recover from blast searches without transcripts.
It can be surmised the first seleoncysteine in both SEPP1 and SEPP2 has a different functional role from terminal selenocysteines in SEPP1, possibly a conserved redox role distinct from selenostorage function of exon 4 in SEPP1. SEPP2 is very likely functional in all the species in which it occurs because of its conservation. There is no indication it is "on its way out" in marsupials -- the SECIS would be obliterated very quickly if the gene were non-functional.
SELU: 3 paralogs, variable timing losses
SELU: This family consists of three deeply diverged (distinct exon patterns) paralogs. The encoding gene has 5 average exons with anomalously short introns like many selenoproteins. In the SELU1 group, selenocysteine occurs in a UxxC motif already in the earliest deuterostome but drops out in mammals after monotremes, being replaced by CxxC in marsupials and placentals. Amphibia separately lost selenocysteine.
The second paralog SELU2 has selenocysteine in bilaterans only to the node of sea urchin, suggesting it was lost early in the deuterostome ancestor. It is the closer paralog of SelU1, 36% vs 27% percent identity. No vestigal SECIS element persists in living species that encode cysteine. (The decayed SECIS elements still identifiable in 3' UTR of cysteine-containing GPX6 genes in rodents and human GPX5 represent much more recent loss of selenocysteine.)
The third paralog SELU3 has cysteine in all species for which a sequence is available. It might be called virtual selenoprotein supposing orthologs in early diverging eukaryotes could be located that contained selenocysteine. This would suggest a scenario in which selenocysteine was present in an ancestral gene prior to gene duplications followed by conversion to cysteine in different phylogenetic patterns within each gene subfamily.
This family exhibits the "selenocysteine rachet": if selenocysteine happens to be replaced by ordinary cysteine (despite catalytic inferiority) in some stem lineage, the unselected 3' UTR SECIS element then deteriorates over a few million years from accrued mutations, for the same reason (lack of purifying selection) the crayfish in the cave loses its imaging opsins. Consequently the whole following clade will contain cysteine -- a reversion to TGA at the cystein codon might occur but it would simultaneously require a multi-step reversion or de novo evolution of a SECIS element, ie all SECIS elements are ancient and selenocysteines cannot wink back on paraphyletically. (However the overall selenoproteome can still increase over time because of gene duplications elsewhere.)
A phylogenetic overview of the occurence of selenocysteine in SELU1 in 38 vertebrates:
.........................*..... C Homo sapiens genome EPRTFKAKELWEKNGAVIMAVRRPGcFLCRE C Pan troglodytes AACZ02115591 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Pongo abelii ABGA01228099 EPRTLKAKELWEKNGAVIMAVRRPGCFLCRE C Macaca mulatta AANU01282766 EPRTLKAKELWEKNGAVIMAVRRPGCFLCRE C Microcebus murinus ABDC01489848 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Otolemur garnettii AAQR01538573 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Tupaia belangeri AAPY01309022 EPRTFKAKELWGERGAVIMAVRRPGCFLCRE C Mus musculus AAHY01113156 EPRTFKAKELWEKNGAVIMAVRRPGCFLCR. C Rattus norvegicus AAHX01086750 EPRTFKAKELWEKNGAVIMAVRRPGCFLCR. C Spermophilus tridec AAQQ01288000 EPRTFKAKELWEKSGAVIMAVRRPGCFLCRE C Cavia porcellus AAKN02044618 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Oryctolagus cuniculus AAGW01591660 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Canis familiaris AAEX02011808 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Bos taurus AAFC03065652 ...TFKAKALWEKNGAVIMAVRRPGCFLCRE C Equus caballus AAWR02000382 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Myotis lucifugus AAPE01631988 EPRTFKAKELWEEKGAVIMAVRRPGCFLCRE C Sorex araneus AALT01607337 zPKTFKAKELWSKSGAVIMAVRRPGCFLCRE C Boreoeuthere ancestralis ancestral EPRTFKAKELWEKNGAVIMAVRRPGcFLCRE C Echinops telfairi AAIY01623759 ...TFQSKGALGKNGAVIMAVRRPGCFLCRE C Dasypus novemcinctus AAGV01392885 EPRTFKAKELWEKNGAVIMAVRRPGCFLCRE C Monodelphis domestica AAFR03024314 SPKTFKARELWEHRGAVIMAVRRPGCFLCRE C Trichosurus vulpecula transcript SPKTFKARELWEHRGAVIMAVRRPGCFLCRE C Macropus eugenii genome ..KTFKARELWEHRGAVIMAVRRPGCFLCRE U Ornithorhynchus anatin AAPN01249400 EPRTFKARELWQRNGAVIMAVRRPGUFLCRE U Tachyglossus aculeatus genome EPRTFKARELWQRNGAVIMAVRRPGUFLCRE U Anolis carolinensis AAW.01013574 ..RTFKAEELWKKNGAVIMAVRRPGUFLCRE U Gallus gallus AADN02035315 EPRTFKASELWKKNGAVIMAVRRPGUFLCRE U Taeniopygia guttata genome EKRTFKAGELWKQNGAVIMAVRRPGUFLCRE C Xenopus tropicalis genome EPKSFKAKDLWEKNGAVVMAVRRPGCFLCRE C Xenopus laevis transcript EPRLFKAKDLWERDGAVIMAVRRPGCFLCRE U Danio rerio CAAK04015812 DDRVFKARELWESSGAVIMAVRRPGUFMCRE U Tetraodon nigroviridis CAAE01014976 ETKTFKAKTLWEKCGAVVMAVRRPGUFLCRE U Fugu rubripes CAAB01000016 ETKTFKAKSLWENSGAVVMAVRRPGUFLCRE U Gasterosteus aculeatus AANH01005113 ...VIKGRSLWDKNGAVVMAVRRPGUFLCRE U Oryzias latipes BAAE01190338 DTKIIKAKSLWDKNGAVVMAVRRPGUFLCRE U Fundulus heteroclitus transcript .....KAKSLWEKNGAVVMAVRRPGUFLCRE U Oncorhynchus mykiss CR369769 .....KAKALWEKTGAVVMAVRRPGUFLCRE U Callorhinchus milii AAVX01258517 ENRTFRASELWAGRGAVIMAVRRPGUFLCRE C Gasterosteus aculeatus AANH01005113 ......AKTLWDKTGAVVMVVRRPGCLLCRE (anomalous gene duplication with cysteine)
SEPW1: odd paralog SEPV gained in placentals
Selenoprotein SEPW1 is one of the shortest known mammalian proteins at 87 aa. With its CxxU motif, it is likely limited to simple redox reactions. Curiously, despite the small size protein still has 5 coding exons. One of these is of relatively recent origin because chondrichtyes and telost fish have the second and third exons fused (which, given the tree and extreme rarity of intron gain/loss must be the ancestral condition.
Like many genes on the densely packed human chromosome 19, SEPW1 seems to have given rise to a segmental duplication, here during the placental stem (ie, is absent marsupial and earlier diverging vertebrates). The second copy, called SELV, retains the same intron placements and phases but with greatly expanded and compositionally anomalous exon 1 which is highly prone to large indels (from replication slippage).
This long exon retains some conservation at its distal end to the last 5 residues of SEPW1 (unsurprising because the cysteine of the CxxU motif is at the end). There is observable conservation also at the amino terminus but otherwise the exon is evolving unconstrained. Possibly the initial methionine of SEPW1 was lost at the time of duplication but the terminal residues and splice donor were retained. Transcription far upstream lead to a remote methionine serving as replacement.
This is a very odd gene but transcripts in a half dozen species and moderate conservation (75% within placental mammals) in exons 2-5 over hundreds of millions of years witin placentals proves that it is evolving under selective constraint and so is functional. Distal exons however retain only 50% conservation to those of SEPW1, far too little to support ongoing gene conversion.
DIO1, DIO2, and DIO3: a curious history
The iodothyronine deiodinases of selenoproteins have been thoroughly studied because of their role in thyroid hormone metabolism. The three paralogs seen in mammals diverged long ago -- the percent identity today is about 45% and exon breaks and phases are completely unrelated. One scenario is that DIO2 and DIO3 in mammals arose as an initial retroprocessed gene that then duplicated again, with DIO2 subsequently acquiring an intron and DIO3 remaining a single coding exon. The critical era for exon acquisition and loss is poorly represented in the databases.
DIO2 and DIO3 are found on the same chromosome arm of chr 14 in human but separated by 22 Mbp, rather far for a tandom duplication. This structure is conserved in the chicken genome with only 8.7 Mbp intervening. Again, it is hard to sort out coincidence from correlation. Note the SECIS element might well accompany both retroprocessing and tandem duplications.
No 3D structures are available for this family of proteins (which have a single N-terminal transmembrane segment) but deiodinases have thioredoxin-like fold (which includes glutathione peroxidase selenoproteins) according to SuperFamily. This domain might serve to define trimming for purposes of better protein trees as well as serve as a partial template for folding (noting too a short insert with strong similarities to the active site of iduronidase, a GH-A-fold of glycoside hydrolase).
DIO1 catalyzes the outer ring deiodination of T4 to the biologically active hormone T3, as well as the degradation of T3 and sulfated iodothyronines. DIO2 is also involved in outer ring deiodination. DIO3 converts T(4) to T(3) and T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. This gene is imprinted and has an anti-sense transcript. These genes are of great interest in the evolution of the thyroid (resp. endostyle) and its hormones.
The putative redox motif varies significantly across the three paralogs, with the CxU motif of DIO1 and DIO3 becoming AxU in DIO2 (meaning it cannot form a local seleno-disulfide). All three proteins contain a distal conserved cysteine; DIO2 has an additional conserved cysteine still further downstream.
DIO1 GSCTuPSF...PQCPV DIO2 GSATuPPF...PQCRV...RVCIV...KRuKK DIO3 GSCTuPPF...PGCAL
Remarkably, a second selenocysteine may have arisen in near-terminal position post-lungfish divergence (ie after teleost fish divergence). No experiment specifically addresses this TGA codon but it is conserved here over billions of branch length years and could be supported by the same SECIS element that supports the first selenocysteine. It may have arise from read-through of a TGA stop codon; no clear counterpart is seen in this position in DIO1 or DIO2. Note ancestral CTU in the proximal selenocysteine had already morphed into ATU by lamprey and chondrichthyes. Alanine of course has a chemically inert sidechain; possibly the second selenocysteine now contributes the second half of a redox pair. Additional species might further buttress the second selenocysteine but the possibility always remains that the TGA is the actual stop codon and is conserved for other unknown reasons.
DIO2_homSa SKRuKKT DOI2_macMu ....... DOI2_canFa ....N-- DOI2_otoGa ....N-- DOI2_tupBe ....N-- DIO2_ratNo ....ILD DIO2_susSc .....LD DOI2_equCa .E..N.L DOI2_echTe ....T-- DOI2_sorAr ....NSL DOI2_bosTa .....-- DOI2_dasNo ....N-- DOI2_monDo ....NPG DIO2_ornAn ....NPD DIO2_galGa ....NPL DIO2_anoCa ....NPL DIO2_neoFo R...VP. DIO2_xenTr G...T DIO2_gasAc G..FSR. DIO2_takRu GPHLI DIO2_funHe GR. DIO2_oryLap ...K... DIO2_tetNi G.. DIO2_danRe G.u DIO2_calMi GQ.WG
The collection of DIO1 below from 49 species illustrates the importance of rare genomic events in defining the topology of the mammalian species tree. Here we see a 5 residue insert in the first exon restricted to Pegasoferea (ie excluding artiodactyls) with no hint of homoplasy. Additionally a longer deletion is restricted to Afrotheres.
DIO1_homSa MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQ DIO1_panTr ..................................................................................................H............. DIO1_macMu .....S...V.K................................................................................................D... DIO1_calJa ....G..................A......T.......K......D........N...........................................H.........D... DIO1_otoGa ....R..........F.......A...M..........SQ.....QQ.V.AK.............LQHPV.LVCPEGPL.....M..R.........SAS...K....D... DIO1_musMu .....LW......VIF.Q..LE.A.....MT...G...QS.....Q....A...R.AP...V.....I................RA.F.......T..C....K....D.I. DIOI_ratNo ...S.LW......VIF.Q..LE.AT....MT...E...Q......Q........R.AP...V.....I................RA.Y.......T.......K..V.D.I. DIO1_oryCu ....R...........VQ...E.A.....MT...E...Q......Q...IAQ..N.AQ.S........................A..P.......S.......Q.S..D..R DIOI_cavPo ...TW...........VQ...E.AM....MT...E.I.KS..............Q..................I.........E.A.......D.S..C...EKRT..D..H DIO1_canFa ....R.V...R......Q...Q.A....F.K...A...QH.V..NGN-----K....Y...A..LY.M.........Q......R..P....................D... DIO1_ursAr ....R.V...R......Q..M..A..........E...QQV...NK.-----.....Y...L...Y.M................R..P....................D... DIO1_felCa ...S.L....R.....FQ..LQ.A....F.....S...QH.V..NR.-----.....Y...A..LY.V................R..P.................S..D..K DIO1_equCa ....RA...........Q..LQ.A......T.......QH.V..NQ.-----.....Y...V..LY...........H........KR......S.............D... DIO1_myoLu ..............I..Q..L..TL...Q.K...R...QH....NR.-----.....Y...A..L...P....I..........K..E.S...............H..D... DIO1_pteVa .E..W..R.........Q..L..A....Q.T...R...Q..V..NR.-----.....F...L..L...............Q.....KE..........C.........D... DIO1_sunMu ....GL..L...FG..VR..LK.A......T.W.SAIRPHL...S.....AK..R.TYED.A...............N..Q...R.KQ.DI..DS...H.....ARL.D... DIO1_bosTa ....S...........FQ..L..AI.....T...R...Q...................E..............I..........M..Q..............E..S..D... DIO1_turTr ....L...........FQ.GL..AM.....T...R...Q.....S.....AK.....YE........A.....I..........M..Q..R.................D... DIO1_susSc .E..L...........FQ..L..AM....MT...G...QD....SQ....AK......E........A................K..E..........S......H..D... DIO1_vicVi ...SL...........FQ.VL..AL.....T...G...QD....SQR...AQ.....YE..............I.............Q.....D....C..-D.VH..D... DIO1_eriEu ....S...........FQ..L..AI.....T...R...Q...................E..............I..........M..Q..............E..S..D... DIO1_dasNo ...S..........I.FQ..L..A...T..T...G...Q....KSQ.SHKAE....PY...G....N......L..IG......K..Q..........H.........D... DIO1_choHo ...SW............Q..L..AM..I..T...G...Q.....SRRANN.KD.Q.PY...G....N.................K..Q..........H..R......D... DIO1_loxAf ..............IF.K..L..AM.........G...K....Q--------....AY.M.GS.L..IP....I...Y......K..E..P..D....C........SD... DIO1_proCa ......V..........R..L..AM.....A...G...K....Q--------....AY.M.CS.L..VP........Y......K..E..........H.....R...D... DIO1_monDo .LRLWLW.........Q.VG..LM..LMKM.S...M.QH..G..Q.SSIFQ..N.KYE..G....TLP..L...R........QALQ..P..D....S.R..PRRL.D..HA DIO1_triVu . AG.L..VR.F.A..Q..F......L.KT...NMM.KH..SL.QRSSISQ.TQ.AYE..G.....I...F............QALQ......P...T.K.ESRH..D..H DIO1_anoCa . FKA.RLVLKT.L..Q.CLSTA...LFM....ATA..Y..KQS.RSS.G...N.VYE..G.....F..LL.....K.K....KALQ.CP...T...DFD.KIHH.LD...
SELH: rapid evolution
SELH is another small selenoprotein with a conserved CxxU redox motif split by a phase 21 intron. The introns in mammalian SELH are exceedingly short (eg, 93 and 162 bp in human with gene coding span very short at 619 bp) but the level of transcription is not remarkable so provides no explanation for the lack of retroposons. Some species like orangutan have processed pseudogenes, implying transcription in germ-line tissues. Zebrafish has a diverged duplicate gene with tryptophan at the seleocysteine site in addition to an intronless transcribed gene with TGA selenocysteine -- it appears that this has displaced the normal three-intron gene (seen in other fish). That can work in selenoproteins since retropositioning begins at the 3' end of transcripts, meaning the SECIS likely accompanies the coding region.
Protein conservation is below average -- SELH percent identities (to human) drop to the low 80's within Laurasiatheres, to 72% with marsupial, and 57% with chicken. Further, rodents exhibit significant residue loss upstream of the CxxU motif, very unusual in such a short protein but indicative of an inessential structural region. Indeed observed conservation is primarily centered in the middle of the protein. No phylogenetic conversion of selenocysteine to cysteine is observed within vertbrates
SELM: retained in ER
Another selenoprotein of unknown function, SELM with CxxU motif, surfaces during Blastp searches using selenoprotein SEP15 (which oddly has a CxU motif) as query. A 3' UTR SECIS element cannot be located with SECISearch 2.19 yet it seemingly must be located in the comparative genomic peaks of conservation lying between SELM and the neighboring gene.
Since the protein is quite short with 5 introns, complete SELM sequences are best recovered from cDNAs and genomic alignments in the UCSC 28way. This is an ancient protein recoverable from vertebrates, amphioxus, sea urchin, shrimp, mite, moths, and hydra, and plants. Moths (silkworm and hawkmoth) -- but not their outgroups -- encode cysteine in a CxxC motif in place of CxxU. No loss of selenocysteine is seen in 22 species of phylogenetically dispersed vertebrates.
SELM may begin with a signal peptide. There are no glycosylation sites nor additional conserved cysteines beyond the CxxU motif. SuperFamily finds no similarity to proteins of known 3D structure. The terminal residues appear to be a phylogenetically conserved KDAL-class endoplasmic retention signal
In whole-mount zebrafish embryos, SELM is expressed within the notochord and anterior somites, axial fin fold, dorsal spinal chord neurons, then in lateral line neuromasts. SelM is located in the ER/Golgi as is its distant homolog Sep15 (found associated with UDP-glucose glycoprotein glucosyltransferase, an ER-resident protein involved in quality control of protein folding).
MSRB123: methionine sulfoxidases
MSRB1 is a short odd protein, rich in cysteines, with two CxxC motifs, a near-amino terminal cysteine and a more distal selenocysteine in a motif with serine. MSRB is now known to be a stereospecific methionine-R-sulfoxide reductase repairing oxidative damage to methionine in native proteins. The two pairs of cysteines bind a zinc atom. The all-beta structure has been determined in a bacterial homolog with a internal structural duplication so weak it needs an xray determination to be revealed. Humans have 9 such domains in 9 proteins according to SuperFamily. These could potentially encode other selenoproteins at least in some species.
The fold exists as a small family of paralogs, three in mammals, with specialization to cell compartment -- cytosol, mitochondria and endoplasmic reticulum (via KAEL* signal), respectively.). All contain catalytic zinc. This multiplicity of MSRB contrasts with a single non-homologous methionine-S-sulfoxide reductase (not a selenoprotein in any species).
MSRB1 has selenocysteine in its active site in conserved motif UxxS, whereas MSRB2 and MSRB3 contain Cys in the well-conserved motif CINS. The cysteine in the Ux53xC motif of prokaryotes is replaced by serine or threonine in all eukaryotic MSRBs as U/CxxS/T. While serine and threonine have polar hydroxyl groups reminiscent of a cysteine, whether they form a covalent bond with the selenocysteine or otherwise contribute to catalysis remains unresolved. Thus this protein has a defunct CxxU motif that was unusual among selenoproteins in having 53 intervening residues.
The exon structures, relative to reliably locatable CxxC anchors, show MSRB2 and MSRB3 more closely related (having a distinctive break within the second CxxC motif), whereas MSRB1 introns are placed altogether differently. This suggests two rounds of gene duplication with intronation of MSRB2/3 prior to the second round. A tree based on the alignable conserved core of these proteins indicates the same result.
The phylogenetic distribution of orthologs of MSRB1 is orderly, with selenocysteine back through fish, with no counterpart currently locatable in amphioxus or tunicates (which otherwise have 3 MRSB genes). Further, there is no sporadic appearance of selenocysein in MRSB2/3 -- cysteine is always found, even prior to bilatera, suggesting though selenocysteine is ancestral (viz prokaryotes) but became cysteine prior to the second duplication giving rise to MRSB2/3.
Care must be taken at greater depth because of possible confusion among paralog members (and lineage-specific expansions and contractions). Synteny is lost so intron phasing and siting must be used along with blast clustering. The selenoprotein rachet predicts as more species are sequenced, some clades may exhibit lost selenocysteine in MRSB1 but none will acquire it in MRSB2 or MRSB3 lineages.
This raises the question that if selenocysteine is not necessary, why is it retained in MSRB1? Possibly that has some connection to localization in the reduced cytosol whereas more oxidizing mitochondrial and ER compartments utilize cysteines. In this view, selenocysteine will not be lost in any vertebrate clade no matter how many species are sequenced for MSRB1; whereas in MSRB23 cysteine was an adaptive change rather than mere rift, allowing wider intracellular distribution. Evidently methionine sulfoxide forms in all three compartments.
32 vertebrate MSRB1 aligned in exon 3: VSCGKCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFVPK homSap Homo sapiens (human) VSCGKCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFVPK panTro Pan troglodytes (chimp) VSCGKCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFVPK ponPyg Pongo pygmaeus (orang_sumatran) VSCGKCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFVPK macMul Macaca mulatta (rhesus) VSCGRCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFIPK otoGar Otolemur garnettii (bushbaby) VSCGRCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK micMur Microcebus murinus (mouse_lemur) VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFVPK musMus Mus musculus (mouse) VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK ratNor Rattus norvegicus (rat) VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK cavPor Cavia porcellus (guinea_pig) VSCGKCGHGLGHEFLNDGPKPGQSRFuIFSSSLKFIPK oryCun Oryctolagus cuniculus (rabbit) VFCGKCGHRFGHEFLNDGLKPGQSRFuIFSNTLKFVPK ochPri Ochotona princeps (pika) VSCGKCGNGLGHEFLNDGPKPGKSRFuIFSSSLKFIPK canFam Canis familiaris (dog) VSCGRCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFIPK felCat Felis catus (cat) VSCGRCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK bosTau Bos taurus (cow) VSCGRCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK susScr Sus scrofa (pig) VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFVPK equCab Equus caballus (horse) VSCGRCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPR eriEur Erinaceus europaeus (hedgehog) VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK loxAfr Loxodonta africana (elephant) VSCGKYGHGLGHEFLNDGPNWGQSRFuIFSSSLKFIPK echTel Echinops telfairi (tenrec) VSCGKCGNGLGHEFLNDGPKKGQSRFuIFSNTLKFVPK triVul Trichosurus vulpecula VSCGKCGNGLGHEFLNDGPRRGQSRFuIFSSSLKFIPK ornAna Ornithorhynchus anatinus (platypus) VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK galGal Gallus gallus (chicken) VLCGKCGNGLGHEFINDGPKKGQSRFuIFSSSLKFVPK anoCar Anolis carolinensis (lizard) VSCGKCGNGLGHEFINDGPKKGQSRFuIFSSSLKFIPK xenTro Xenopus tropicalis (frog) VRCGKCGNGLGHEFVNDGPKHGLSRFuIFSSSLKFIPK danRer Danio rerio (zebrafish) VRCGKCGNGLGHEFLNDGPSRGLSRFuIFSSSLKFIPK tetNig Tetraodon nigroviridis (pufferfish) VRCGKCGNGLGHEFVNDGPSRGLSRFuIFSSSLRFIPK takRub Fugu rubripes (fugu) VRCGKCGNGLGHEFVNDGPAKGVSRFuIFSSSLKFIPK gasAcu Gasterosteus aculeatus (stickleback) VRCGKCGNGLGHEFVNDGPSKGLSRFuIFSSSLKFIPK oryLap Oryzias latipes (medaka) IRCGKCNNGLGHEFLNDGPKHGLSRFuIFSSSLKFV.. ictFur Ictalurus furcatus (fish) VRCGKCGNGLGHEFVGDGPKKGLSRFuIFSSSLKFV.. oncMyk Oncorhynchus mykiss (trout) VRCGKCGNGLGHEFVGDGPKKGLSRFuIFSSSLKFV.. salSal Salmo salar (salmon) .SCGKCGNGLGHEFLNDGLKAGQSRYuIFSNSLKFVPK calMil Callorhinchus milii (elephantfish)
SEPHS1 and SEPHS2: selenophosphate synthetases
Selenophosphate synthetases are biosynthetic enzymes that capture selenium in a chemical form suitable for selenoprotein biosynthesis. One of the two mammalian selenophosphate synthetase paralogs, SEPHS2, itself contains a selenocysteine in a conserved UGCK motif several dozen residues in from the amino terminus. This motif contains threonine as TGCK in SEPHS1 which apparently functions in a selenium salvage system recycling catabolic selenocysteine (tRNA is charged with precursor serine), whereas the SEPHS2 enzyme functions in selenite assimilation (selenophosphate from selenide and ATP). Unsurprisingly only SEPHS2 has a selenocysteine insertion sequence (SECIS) element in 3' UTR.
This gene family has a curious evolutionary history: every additional level of phylogenetic resolution adds another twist -- even 29 genomes from cnidarian to placental do not provide adequate genomic saturation. The original single-copy gene (itself an ancient internal tandem duplicatation fold with active site on dimeric cleft) procedes uneventfully from ur-bacteria to hagfish/lamprey divergence.
However, prior to teleost fish divergence, block duplication of the 8 exon gene took place. No flanking synteny persists in extant species. The copy that would remain closest to the ancestral gene then lost its selenocysteine to nucleophile threonie, its 3' UTR SECIS insertion element decayed, and the old function strayed to salvaging selenide from free selenocysteine (arising from selenoprotein catabolism or diet). The copy we call SEPHS2 diverged rapidly ( rather unconstrained amino terminus in both length and sequence) but with conservation about the selenocysteine active site motif and beyond.
Between monothere and marsupial divergence, a fully processed retrogene (no introns) carrying the 3' UTR SECIS insertion element became functionally established, remarkably displacing the previous 8-exon gene (now an undetectable decayed pseudogene or deletion), to the extent that every species of placental mammal retains only the processed retrogene and threonine copies. Opossum, but not platypus nor elephant or tenrec, retains all 3 gene copies.
Here the processed retrogene mechanism (begin at 3' end of UTR but not extend necesarily to initial methionine or 5' regulatory regions) brings along the SECIS selenocysteine insertion loop making a new selenoprotein feasible and while explaining non-homologous start peptides. Humans have an assortment of fragmentary and processed pseudogenes for which SEPHS1 is usually the parent, most notably a mis-spliced processed pseudo omitting exon 7 (build 35, chr7:63756925-63757879).
Reference set of 341 vertebrate selenoproteins
SEPP2: 12 vertebrate sequences
>SEPP2_monDom Monodelphis domestica (opossum) chr2:9,451,774-9,455,977 1 selenocys tga stop taa 0 MPPPGLSLAVLLGLLGASLAFENRTRFCQPAPPWQVGGGRAPMEEALGNVTVVALLKASuHFCLKQAAS 2 1 MGSLQERLARMGAPDVRFIIVNEKSPQSRALHGELELHAPPGVPVYGQPELGPDIWSILGGAKDDFLIYDR 2 1 CGRLTFHIRLPFSFLHFPYVESAIRFTHRQDSCGNCSFYPAQ 0 0 VNSTDERKGESKHSPGLEGEGQEPLGEKPDSRGLTLGSSAPTAHAHDPVHGGMEKPSPSLPSPALEPSLHEGEAPG* 0 >SEPP2_macEug Macropus eugenii (wallaby) trace archive tga stop taa 0 MGLPGLAAALLLGLVGATLASENGTRICQPAPKWQVDRGASPMEEALGQVTVVALLKASuHFCLKQAAS 2 1 IGNLQERLARVGATGVRFIIINEKSPLSQALYGELELHAPSGVLVYNQQGPGPDIWSILGGAKDDFLIYDR 2 1 CGRLTFHLPLPLSFLYFPYVESAIRFTHQQDHCGNCSFYPAQ 0 0 VNNTDKGKAESLTQSPRLEGEGQESLAEGPSTHGPTLWPSTPHPAHARGPVHSPGSKRLSPSLPPPSLEWPPHEEANK* 0 >SEPP2_ornAna Ornithorhynchus anatinus (platypus)synteny last exon uncertain 0 MAGSGLLGPALTLATLLAAAGALPDLENGTRICQPAPRWTVNGVAPMEGTEGQVIVVALLKASuHFCLKQAAR 2 1 LAGLRERLAGHGAGNVSFLIVNQRDPTAQLLHTELERHAPPGVPVYAQDGPDPDVWSVLGGDKDDFFVYDR 2 1 CGRLTFHIQLPFSFLHFPYVEAAVRFTHRRDFCGNCSYYFPQVGT 0 0 VNDTTTQESELEKSPGAPGEEPEGSPVREPDRPQSQDPTGPFSGVLLQGKENKIIPWKTPLQAAPRKPSHPPGAHD* 0 >SEPP1_tacAcu Tachyglossus aculeatus (echidna) EUEMSW408ERBZB length=227 run=R_2007_08_22_12_11_10_ 59% 1 VPVYAQDGPDPDVWSILGGGKDDFLVYDR 2 1 CGRLTFHIRLPFSFLHFPYVEAAVLFSHRHDFCGNCS >SEPP2_galGal Gallus gallus (chicken) taa stop synteny Zswim5 HPDL MUTYH 0 MGSLLLALASCLGLAVASEGATNGSRLCHEAPAWRINGSSPMEGAAGQVTVVALLKASuHFCLLQARS 2 1 LGALRERLGQQGVSDVRYVIVNEQAPLSRAMFGELQRHAPPGVPVLQQQPHEPDVWQLLGGDKDDFLVYDR 2 1 CGRLAFHIQLPYSFLHLPYVESAIRFTHRKDFCGNCSLYPNSTQE 0 0 ANSTMEVPATLTPLPKQEEKESETPAHHQPNHLHPHHRAVGNGTAPEPSGDHRPAHAHHHHGAHGKLHPKGQTPEGRDP* 0 >SEPP2_taeGut Taeniopygia guttata (finch) 0 MGLLVLALATWLGLGLASASEETANSSRICQEAPAWTINGSSPMEGAAGQVTVVALLKASuQFCLRQAHS 2 1 LGGLRERLARQGMADVRYMIVNEKAPLSRAMLPELQRHAPPGVPVFQPEREDPDVWQVLGGDKDDFLVYDR 2 1 CGRLAFHIQLPFSFLHFPYVEAAIRSSHIKDFCGNCSLYPNTTQE 0 0 ANSTMEGPATPSSLPEHEGMESETPVHQHKPLHPHRHHEVNSERDTNPSEDHKPATHAHHHHGDHGQLHHKGRKQKEGDEH* 0 >SEPP2_anoCar Anolis carolinensis (lizard) scaffold_4:5,993,109-5,994,846 0 MDYSLATRILLLGLVVISATQAEVTENKTRICQPAPLWKINGTAPMAGMEGQVTVVALLKASuPFCLKQAAK 2 1 IGGLQKKLSNEGVANVSFLIVNEKTPLSRAMYWELKRNAPQGIPVYQQQILEPDVWQILDGDKDDFLIYDR 2 1 CSRLTFHIQLPYSFLHLPYVEAAVHYTHRKDYCGNCSRYYSE 0 0 * 0 >SEPP2_xenTro Xenopus tropicalis (frog) NM_001006907 misannotated, no selenocysteine 0 MHNLALTVSILMGLLGQVSSSEQTNSSICKPPPKWSIEGEVPMAEALGKVTVVALLQASCGFCLVQAAR 2 1 MGPLRYKLSLQGMTDIKYMIVNDQSLHSANMFPELKRWAPEGIPVYQQTPGQDDVWELLDGNKDDFLIYDR 2 1 CGRLTFHVRLPLSFLHFPYVEAAILSTYNESFCGNCSFTSNSTLIPM 0 0 NGTTVSPSGDDSSSPLQNKDEPVNKEPSPTLEKHNDQRKLDSELRLHDHSQHHPINSHKRQENQNNHPRNLIKNGKQN* 0 >SEPP2_tetNig Tetraodon nigroviridis (pufferfish) from cDNA, genome misassembled 0 MSSPWLLWLQVALTGLLWASQGQSATSRICKAAPRWEVGGQAPMEALVGRVVVVALLKASuQFCHIQASK 2 1 IGPLREKLSRRNVTEVSFVIVNEQEPVSRALYWQLRRRAPPGVPVYQQAPLQDDVWEALDGDKDDFLIYDR 2 1 CGQLTFHIGLPYSSLRYTYVEAAVIATHQGNICNCS 0 0 ANFTSLSISNSSGSGGMPSQTNQTVTAETDGPHTTHHHPHPHRHHHHHQHLSPEQPTPTAMPGQATPTPA* >SEPP2_gasAcu Gasterosteus aculeatus (stickleback0 chrIII:3,915,059-3,917,020 0 MTPPGSASRPPHWTIKERAPMQELLGNVVVVALLKASuQFCLTQASK 2 1 IGGLRDKLNRSNLTDVSFMIVNEREPHSRAMYWELKRRAPPGVPVYQQAALQSDVWEALDGDKDDFLVYDR 2 1 CGLLTFHIVLPYSFLHNVYVEAAIRATYLKNICNCT 0 0 VDSVVSSLNNSVMNNETDFNVSQTNATPRIQPDTNDPEGAGTPPPPT >SEPP2_leuEri Leucoraja erinacea (skate) cDNA 0 MGLQRSLLIILVGAAITLAAANNDTRICQVAPHWEIGNQSPMEQLSGQLVVVALLKASuQFCLTQAAKLGILRDKLSLQGLKNIHYIIVNEKT LESRAMFWKLKLKTPKNITVYQQSAFQPDVWRILRGNKDDFLIYDRCGKLTFHITSPYSYLNFRYVEAAIMATYNTDYCGNCMGSSTTLEATS >SEPP2_calMil elephant fish Callorhinchus milii (elephantfish) 1 LGSLQDKLARQGLKDVHYMIVNEKAPESRAMLWELKRHVPNNVSVYQQSPIQPDVWHSLQGGKDDFLIYDR 2 1 CGRLTFHVVLPYSSLQYPYIEAAIRATHKRDICGECTIT 0
SELU1: 13 vertebrate sequences
>SELU1_homSap Homo sapiens (human) chr10 processed pseudogenes chr8 and chr12 0 MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEK 1 2 EPRTFKAKELWEKNGAVIMAVRRPGcFLCREE 0 0 AADLSSLKSMLDQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEK 0 0 KKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQ 0 0 GILLEHRENEFGDKVNLLSVLEAAKMIKPQTLASEKK* 0 >SELU1_monDom Monodelphis domestica (opossum) tgt-cys 0 MSFLDLNFFSMSMWSLGAGALGAAALSLILANTDLFLTKSVDATLEFLEEIQLKTLDN 1 2 ESPKTFKARELWEHRGAVIMAVRRPGCFLCREV 0 0 AADLSALKPQLDLLGVPLYAVVKEKIGSEVENFQPYFKGKIFLDER 0 0 KKFYGPQKRKMMFMGFVRLGVWQNFFRARSKGFSGNLEGEGFVLGGVYVIGPGKQ 0 0 GILLEHREKEFGDKVNPASVLEAAKKIKPHTSTSEGK* 0 >SELU1_macEug Macropus eugenii (tammar wallaby) EX196548 full 0 MSFLDLSFLSMGMWSLGAGALGAAVLSLILANTDVFLTKSVTATLEFLEDIELKTLDN 1 2 KTFKARELWEHRGAVIMAVRRPGCFLCREE 0 0 AADLSALKPQLDQLGIPLYAVVKEKIGSEVEDFQPYFKGKIFLDER 0 0 KKFYGPQKRKMMFMGFVRLGVWQNFFRARSKGFSGNLEGEGFILGGVYVIGPRKQ 0 0 GILLDHREKELGDKVNPASVLEACKKIKLHA* 0 >SELU1_triVul Trichosurus vulpecula (brushtail opossum) EC360881 0 MSFLDLSFFSMGMWSLGAGALGAAVLSLILANTNLFLTKSVTATLEFLEEIELKTLDN 1 2 ESPKTFKARELWEHRGAVIMAVRRPGCFLCREE 0 0 AAELSALKPQLDQLGIPLYAVVKEKIGSEVENFQPYFKGKIFLDER 0 0 KKFYGPQKRKMMFMGFVRLGVWQNFFRARSKGFSGNLEGEGFILGGVYVIGPGKQ 0 0 GILLEHREKEFGDKVDPASVLEAA * 0 >SELU1_ornAna Ornithorhynchus anatinus taa early stop full 0 MPLPPDLGLFNLGMWSVGVGALGAAAVGLLLANTDLLLTKPEKATLEYLEDTELKTLGK 1 2 EPRTFKARELWQRNGAVIMAVRRPGuFLCREE 0 0 AAELSSLKPQLDRLGVPLYAVVKEKIGTEVEDFQPYFKGEIFLDER 0 0 KKFYGPHKRKMLFLGFIRLGVWQNFLRARNRGFSGNLEGEGLILGGVYVLGAGKQ 0 0 GILLEHREREFGDKVSPASVLEAAQRIKPQPL* 0 >SELU1_tacAcu Tachyglossus aculeatus (echidna) 454:EUEMSW405C31QQ (74%) tSASEKK terminus? frag 0 1 2 EPRTFKARELWQRNGAVIMAVRRPGuFLCREE 0 0 AAELSSLKPQLDQLGVPLYAVVKENIGTEVEDFQPYFKGEIFLDER 0 0 KRFYGPHKRKMLFLGLIRLGVWQNFIRARNKGFPPVTWEGEG 0 0 GVLLEHREREFGDKVSPASVLEAAQKIKPQ* 0 >SELU1_galGal Gallus gallus (chicken) 0 MSFLPDFGIFTMGMWSVGLGAVGAAITGIVLANTDLFLSKPEKATLEFLEAIELKTLGS 1 2 EPRTFKASELWKKNGAVIMAVRRPGuFLCREE 0 0 ASELSSLKPQLSKLGVPLYAVVKEKIGTEVEDFQHYFQGEIFLDEK 0 0 RSFYGPRKRKMMLSGFFRXGVWQNFFRAWKNGYSGNLEGEGFTLGGVYVIGAGRQ 0 0 GVLLEHREKEFGDKVSLPSVLEAAEKIKPQAS* 0 >SELU1_taeGut Taeniopygia guttata (finch) 0 msflpdfgiFTMGMWSVGLGAIGAAVTGIVLANTDLFLSKPEKATLEFLEEIELKTLGS 1 2 EKRTFKAGELWKQNGAVIMAVRRPGuFLCREE 0 0 ASELSSLKPQLSKLGVPLYAVVKENIGTEVEDFQHYFKGEIFLDEK 0 0 KGFYGPRRRKMMLSGFFRLGVWQNFVRAWRSGYSGNLEGEGFTLGGVYVIGAGRQ 0 0 GVLLEHREKEFGDKVSLPSVLEAAEKIKPQAS* 0 >SELU1_anoCar Anolis carolinensis (lizard) 0 MWTIGLGAIGAAVTGIILANTDLFLSKAEQASLDFLEAIDLKTLGE 1 2 NQRTFKAEELWKKNGAVIMAVRRPGuFLCREV 0 0 AAELSSLKPQLDKLGVPLYAVVKENLGTEVMDFQPYFKGEIFLDEK 0. 0 KQFYGPQKRKMLFMGFIRCSVWRNFFRAWKSGYTGNIDGEGFVLGGVFVVGPGKQ 0 0 GVLLEHREKEFGDKVSLDAVLEAVKNIQPQPSEKDK* 0 >SelU1_takRer Takiugu rubripes (fugu) 0 MGLLAKLLAAVGGFVTAVMNSVTDAFLTPPLRATLEHLEETDLKTLSG 1 2 ALVIRLIPTRTETKTFKAKSLWENSGAVVMAVRRPGuFLCRE 0 0 EAAELSSLKPRLDQLGVPLYAVVKEDVGTEIQNFRPYFQGEIFLDEK 0 0 RRFYGPRERKMGLLGFLRVGVWMNGLRAFRSGFMGNVLGEGFVLGGVFVIGREQQ 0 0 GILLEHREREFGDKVNIEDVIQAVDRIAQELMPVTQN* 0 >SELU1_calMil Callorhinchus milii (elephantfish) frag 2 ENRTFRASELWAGRGAVIMAVRRPGuFLCRE 0 0 AAALSSLRPSLAQLGVPL 0 GHLLEHREKEFGDAVNLTAVMEAAGKISPRQSAE* 0 >SELU1_squAca Squalus acanthias (spiny dogfish) also selenocysteine 0 MVVVVEDFHMGLWTLGLGALGAAITGVILANTDLLLPKAETASLAYLSGAELRTLDR 1 2 EERTLKAGDLWSRSGAVIMVVRRPGuFLCREE 0 0 AAEISSLRPQLDELGVPLYGVIKENINNELKNFQPFFKGEIFLDVE 0 0 MRFYGPKPRTMGLMGFMRLGVWKNFVRAWQKGFSGNTDGEGFILgGVFVIGAGQQ 0 0 GVLLEHREKEFGDVVNISSVLEARRKIETQRTEP* 0 >SELU1_bfl Branchiostoma floridae (amphioxus) 8.9 m traces somewhat different intronation 0 MGWRLLVA 00 TMGWVVNAVGVAVVGMVAVNLNFWLPKHIPAQLVHIA 1 2 DAALEELDGNKKKLQAQELWKNHGAVIMAVRRPGuQLCREE 0 0 ALGLSSLKPQLDRAGVPLYAVVHERKGVPEFQPYFQGKVFLDLE 0 0 RRFYGPHERWMSLAGLLRVNFWLNIRRVEKKVEGNYEGEGRLLGGVFVVGSGNQGILMQHAEQEFGHHANLTDIMKAVGEIQHINAKSKI* 0
SELU2: 1 vertebrate sequence
>SELU2_homSap Homo sapiens (human) 7 exons chr1p36.32 36% id NM_152371 0 MSTVDLARVGACILKHAVTGE 0 0 AVELRSLWREHACVVAGLRRFGCVVCRWIAQDLSSLAGLLDQHGVRLVGVGPEALGLQEFLDGDYFAG 1 2 ELYLDESKQLYKELGFKR 2 1 YNSLSILPAALGKPVRDVAAK 0 0 AKAVGIQGNLSGDLLQSGGLLVVSK 1 2 GGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQ 0 0 CDREV* 0
SELU3: 1 vertebrate sequence
>SELU3_homSap Homo sapiens (human) 6 exons chr9q22.32 25% id processed pseudogene chrX 0 MAAPAPVTRQVSGAAALVPAPSGPDSGQPLAAAVAELPVLDARGQRVPFGALFRERRAVVVFVR 0 0 HFLCYICKEYVEDLAKIPRSFLQ 0 0 EANVTLIVIGQSSYHHIE 0 0 PFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASS 1 2 GQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGP 1 2 GNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFTNRPSVIHV* 0
SELV: 19 placental mammal sequences
>SELV_homSap Homo sapiens (human) chr 19 uc002oly.1 66 pro + 32 thr +21 ser first exon 0 MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTLTPVLTPSPAGTSPLVLTPAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPT PVPVRNPTPVPTPARTLTPPVRVPAPAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPAPELPLLPEEDPEPAPSLKLIPSVSSEAGPAPGPLPTRTPL AANSPGPTLDFTFRADPSAIGLADPPIPSPVPSPILGTIPSAISLQNCTETFPSSSENFALDKRVLIRVTYC 2 1 GLuSYSLR 0 0 YILLKKSLEQQFPNHLLF 0 0 EEDRAAQATGEFEVFVNGRLVHSKK 0 0 RGDGFVNESRLQKIVSVIDEEIKKR* 0 >SELV_panTro Pan troglodytes (chimp) essentially identical to humna MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTLTPVLTPSPAGTPPLVLTPAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPTPV PVRNPTPVPTPARTLTPPVRVPAPAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPAPELPLLPEEDPEPAPSLKLIPSVSSEAGPAPGPLPTRTPLAANS PGPTLDFTFRADPSATGLADPPIPSPVPSPILGTIPSAISLQNSTETFPSSSENFALDKRVLIRVTYC 2 1 GLuSYSLR 0 0 YILLKKSLEQQFPNHLLF 0 0 EEDRAAQATGEFEVFVNGRLVHSKK 0 0 RGDGFVNESRLQKIVSVIDEEIKKR* 0 >SELV_ponPyg Pongo abelii (orang) 0 MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTLTPVLTPSPAGTPPLVLTPAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPTPVPVRNPTPVPTPARTLTTPV RVPAPAPAPPPAQVLAGIRAALPILDSYLAPALRLHPPPEPAPELPLSPEEDPEPAPSLKLIPSVSSEAGPAPGPLPARTPQAANSPGPTLDFTFRADLSATGLADPPIPSPVPSPILGT TSSAISLQNSTENFASSSENFALDKRVLIRVTYc 2 1 GLuSYSLR 0 0 YILLKKSLEQQFPNHLLF 0 0 EEDRAAQATGEFEVFVNGRLVHSKK 0 0 RGDGFVNESTLQKIVSVIDEEIKKR* 0 >SELV_macMul Macaca mulatta (rhesus) distal seq from M. nemestrina transcript 0 MNNQARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTQTPVLTPSPARLPALVQPPAPAHIPTQVPTPALARIPGLVPPPARAWIPTPVPTPARVRNPTPVPTPARTLTPPV RVPAPAPDPAQVLAGIRTALPALDSYPAPALSLDSPPEPAQEPPLSPEEDPEPAPSLKLIPSVSSEAGPALGPLPAHTPLAAKSSGPTLDFTFRADPSATGLADPHIPSPVPAPILGTIP SALSLQNFTETLVSTSENFALDKRVLIRVTYC 2 1 GLuSYSLR 0 0 YILLKNSLEQQFPSHLLF 0 0 EEDRAAQATGEFEVFVNGRLVHSKK 0 >SELV_calJac Callithrix jacchus (marmoset) 0 MNNQARTPAPSSARTSTSVRASTPTRTPTPVRTPTAVRIRTPIRTLTPSLAGTPALVPTPTPARISRLVPTPAPARTPTPIPTLVRTLTPVPLPAPARIPAPAPAPAPAPAPAPSPALVP AGIRATLPVLDSYPALALPWDPPPEPVPEPLVSVSSEEDPEPAPSLKLVPSVSGETGPAPGPLPACTPLATNPPEPTLDFTADSSATELAVPTIPGSVPAPILGTIPLAASLLNSTESFL SASENFALDKRVPIRVTYc 2 1 GLuSYSLR 0 0 YILLKKSLEQRFPDCLLF 0 0 EEDRAAQATGDFEVFVDGRLVHSKK 0 0 RGDGFVDEASLQKIVSVIDEEIKKR* 0 >SELV_otoGar Otolemur garnettii (bushbaby) 0 MNSQARASVHPSRTSTAVRASIPARVHPRARTTPVQPRTLITQDRIPAPVRVPP 1 GLuSYGLQ 0 0 YILLRQNLEHHFPNRLLF 0 0 EEGRAAQATGEFEVFVDGKLVHSKK 0 0 NGDGFVDEIRLQKIVNIIDEEIKKRQ 0 >SELV_musMus Mus musculus (mouse) AV279316 58 Pro, 25 Thr, 25 Ser syntenic chr 7 46% hsa! MNNKARVPAPSSVRANTPARTPAPIRTATPVRAPNPAHNSTPVRTSIRVRAPAQVPNPVPIRFPTPAPVPAPTLTPAPTPAPVRHAAPVRTPAPVRAPNLGRV FPKISPGRFFPSLASPTAQPLSSRAASALLKDPTLAQNQKPSIHSLAEAIQGPLPVLTPSSSKTQGSIPDTASPIDSLASTAMASSTLGPIPGPNPTLEFLAS PLKETPGLGKLSTISPAPSFGSTKEIPSTSEDVPTPNRILIRVMYC 2 1 GLuSYGLR 0 0 YIILKRTLEHQFPNLLEF 0 0 EEERATQVTGEFEVFVDGKLIHSKK 0 0 KGDGFVDESGLKKLVGAIDEEIKKR* 0 >SELV_ratNor Rattus norvegicus (rat) chr 1 synteny 83% mmu MNNKARNPAPSSVRANTPSRTPTPVRTATPVRASTPAHNRSPVRTSIRVRTPANPVPIRFPTPAPAPAPTPTPAPTPAPVPAAAPVRTPAPVRASIQGRSFPTIS PVRFLRNLALPAAQPLSSGGAGSLSKDLTLAQKQKPSIHSLAEAIQGPFPVLTPSASSETHGSIPDPAPPTDSLASTAMASSTLDPIPGPKPTLEFLASPLKETP DLGKLSTISPAQNFVSTKEVPSTSEDVPTANRILIRVMYC 2 1 GLuSYGLR 0 0 YILLKKTLEHQFPNLLEF 0 0 EEERATQVTGEFEVFVDGKLIHSKK 0 0 KGDGFVDETSLKKLVGAIDEEIKKR* 0 >SELV_cavPor Cavia porcellus (guinea_pig) 1 GLuSYGFQ 0 0 YTLLKMSLKQQFPNLLRF 0 0 EDERATQVTGEFEVFVEGKLVHSKK 0 0 QGDGFVDDNRMQTIVNAINEEIKRR* 0 >SELV_oryCun Oryctolagus cuniculus (rabbit) 0 MNNQARTPAPAQARTSSVVRASAPTRVSTQIRTPATGWTPTPVQASTPVRTQTPVRTPTLVQASTPVRTPTLGQASTPVRTPTPVQALTPVRTPTPVSGPDSGRTPTPVGTPVGTL 1 GLuSYGLR 0 0 YILLKKNLEELFPDCLLF 0 0 EEERATQASGEFEVFVNGKLVHSKK 0 0 KGDGFVDEVKLRKIVTAINEEIK... 0 >SELV_canFam Canis familiaris (dog) CO599097 0 MNNQARAPPRTSARVLAWVRASTPVRTSIPVRTPTPARIPTSSRAPTSVQTPAPARTPNPVQIPTPVQTSTSARIPNPARTLTPVQTPASAWTPNPVQMLTPARTPTPVPTP VPTPIPARTPTPARTPTPVEAAAAAPASESFGSSALPLEPPPEPASEPTTSPHQDLSPTPSVKPLPSVTNGFGSTQEPLPDLTPPATDFLGPTLGSTSRADSSATKLTDSSESVR VPIPGTPSATALATSTNTFAPVGESCSVKIAVRVIYC 1 GLuSYGLR 0 0 YILLKKSLEQQFPNCLLF 0 0 EEERAAQATGEFEVFVDGKLVHSKK 0 0 KGDGFVDEARLQKIMNVIEEEVRKR* 0 >SELV_felCat Felis catus (cat) 0 MNNQARAPNPSPARVLALVRASTPVRSSIPVRIPTPARIPARTRNPQTPVRAPNPVQIPNPVQISARASNPARAPRPVQIPARTPNPPQTLTPGRAPNPVPTPVQTPTLVQTP TPVQTPTPVWTETPVQTPTAVGTPTRVQTLTPVIPRVRTPTPIRPLWPDPSPNLIPSGPDHPAPESSLRNSAPSFWINSPDSLPAPILETPSTAFASTFENLPEDSKILIRVIYC 1 GLuSYSLR 0 0 YILLRKSLELQFPNCLRF 0 0 EEERSAQATGEFEVFVDGKLVHSKK 0 0 KGDGFVDEARLQKIVSTIDEEIRKR* 0 >SELV_bosTau Bos taurus (cow) DT829759 0 MNNQPRTPAPTPARASTPVRGSTLHRTSIQVRTPTPGPDSGPTRITTLLRTPALIRTLTPIRTPTPVRTPTPVPPSTPVRSPIPVRTPTPVPPSTPVRTPTPVPLSTPVRPPTPVRPPTPVRPPTPVRPPTP IGTPTLIRSPTPVQIPIPEPIPTPIPSRVLIPPLESFPDSALPSGPPLELEPTLTVSPAKNLEPSPAKNLEPSPRVKQVSSAANGFPPIQEPLPALTPLATDLRSPSLGSPLRTDTSTTNLIASSSGHVPGTPILGAIQAILPVPATALASISGNLKEENKIMIRVVYC 1 GLuSYSLR 0 0 YILLRKSLEQQFPNSLIF 0 0 EEEISAQATGEFEVFVDGKLIHSKK 0 0 NGDGFVDEVKLQTIVNLLNEEFKKR* 0 >SELV_susScr Sus scrofa (pig) ti|851198642 CX061656 0 MNNPARAPAPSPVRPSASLRPLASVRASTPARGSTLARTSLLVRTPRTPNLVPASGPGPIRTPTPVRTPTPVRTPTPVRTLTPVRTPTPVRTPTPVRTPTPVRTPTPVRTPTPVQVPTPVRVPTTVGIPTP TLSQVLVPALESLPNPALPSLDPPLEPDPELTLSPDEDPAPTPRAKHLPLVANGFVPVQEPLPALSPLATNLLESTPGAGTDSSTTKLTDSTSGHVPGTPILATIPLAVALPVSTNALASTSENIQVEQQILIRVVYC 2 1 GL*SYGLR 0 0 YILLKKSLEQQFPNCLVF 0 0 EEDISAQATGAFEVFVDGKLVHSKK 0 0 KGDGFVDETKLQKIVSHINEEIKTKVAGSC* 0 >SELV_equCab Equus caballus (horse) 1 GLuSYGLR 0 0 YILLRKSLDQQFPNRLVF 0 0 EEDVGAQASGEFEVFVEGKLVHSKK 0 0 KGDGFVDEARLRKIVSAINEEIKRR* 0 >SELV_myoLuc Myotis lucifugus (microbat) 0 MNHQARASHPFPARTPASVRASIPVRPSNQTPAPSSAPTRTSIPVPASTAVRTPTLVRTPIPFQAVSPVRTSTRFSASVPVQFPTPVSASTPVQTPTRVPAPVRTSTRFPASV PVQFPTPVPASTPVRTSTPVPASTPVQTPTRVPAPAQVRTSIPVPAPAPARTSTPVPAPAPVRTSTTVPAPVPFRTPTPVPAPAPVRTSTPVPAPAPVRTSTPVPAPGPNPDSSPCPGPG 1 GLuSYNLR 0 0 YILLKKSLEQQFPNCLYF 0 0 EEDISEQATGEFEVFVDGKLVHSKK 0 0 KGDGFVDEVKMQKIVNIIDEEIRKN* 0 >SELV_pteVam Pteropus vampyrus (macrobat) 0 MNNKARASAPSLPGTSALVRASAPVRPSTPVRAPTLIRTPTPVRTPNPVPASTPARVPTPVRTLTPVRTPTPIRTPTPVRTQIPFRAANPVRAANPVRTPTPLRTPTPVRTSIPVRTL APVSTPTPIPPPTPPAVPAVVPAAVPGLEFFPSPPPEPVPEPALSPDKDPAPTQSVKHVPSVANEFGLTQEPLSALAPLATDLLGPTRASIRRADPEATKLTGSTAEPSPASILELISSAHIGIASEYLQVDTGSVIRVILL 1 GLuSYNFR 0 0 YILLRKNLEQQFPHGLLF 0 0 EEEVSAEGTGEFEVLVDGKLIHSKK 0 0 RGDGFVDEARLQKIVNVINE IRKR* 0 >SELV_dasNov Dasypus novemcinctus (armadillo) ti|593909023 1 GLuSYALR 0 0 YILLKKSLEMQFPNRLIF 0 0 EEARSSQAVGEFEVFVDGALVHSKK 0 0 RGDGFVDDSKMEKIVSSIEEAVKKT* 0 >SELV_loxAfr Loxodonta africana (elephant) 0 2 1 GLuSYGLR 0 0 YILLRKSLEQQFPNHLIF 0 0 EEDISSQATGEFEVFVDGKLVHSKK 0 0 KGDGFVDDTRLQKIVNSINETIKKE* 0 >SELV_proCap Procavia capensis (hyrax) 0 2 1 GLuSYSLR 0 0 YILLRKNLEQQFPNHLLF 0 0 EVDISSQATGEFEVFVDGKLVHSKK 0 0 KGDGFVDDAQLQKIVNSINETIQRR* 0
SEPW1: 26 vertebrate sequences
>SEPW1_homSap Homo sapiens (human) Selenoprotein W chr19 87 aa uc002phn.1 has retroprocessed pseudogene 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 CGEGTPQATGFFEVMVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_panTro Pan troglodytes (chimp) 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 RGEGTPQATGFFEVMVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_ponPyg Pongo pygmaeus (orang_sumatran) CR926472 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 CGEGTPQATGFFEVMVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_macMul Macaca mulatta (rhesus) 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 CGEGTPQATGFFEVMVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_macFas Macaca fascicularis (cynomolgus_monkey) AB169486 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 CGEGTPQATGFFEVMVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_papAnu Papio anubis (baboon) EY285690 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 CGEGTPQATGFFEVMVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_calJac Callithrix jacchus (marmoset) 0 MALTVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 SGEGTPQATGFFEVTVAGKLIHSKK 0 0 KGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_micMur Microcebus murinus (mouse_lemur) 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGCLDI 0 0 CGEGTPQATGFFEVMVAGKLVHSKK 0 0 GDGYVDTESKFLKLV >SEPW1_musMus Mus musculus (mouse) 0 MALAVRVVYC 2 1 GAuGYKPK 0 0 YLQLKEKLEHEFPGCLDI 0 0 CGEGTPQVTGFFEVTVAGKLVHSKK 0 0 RGDGYVDTESKFRKLVTAIKAALAQCQ* 0 >SEPW1_ratNor Rattus norvegicus (rat) BC087625 0 MALAVRVVYC 2 1 GAuGYKPK 0 0 YLQLKEKLEHEFPGCLDI 0 0 CGEGTPQVTGFFEVTVAGKLVHSKK 0 0 RGDGYVDTESKFRKLVTAIKAALAQCQ* 0 >SEPW1_cavPor Cavia porcellus (guinea_pig) 0 MALAVRVVYC 2 1 GAuGYKPK 0 0 YLQLKEKLEDEFPGCLDI 0 0 CGEGTPQTTGFFEVTVAGKLVHSKK 0 0 GGDGFVDTEGKFRKLVAAIKAALAQG* 0 >SEPW1_oryCun Oryctolagus cuniculus (rabbit) 0 MALAVRVVYC 2 1 GAuGYKPK 0 0 YLQLKKKLEDEFPGCLDI 0 0 CGEGTPQVTGFFEVTVAGKLVHSKK 0 0 RGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_ochPri Ochotona princeps (pika) 0 MALSVRVVYW 2 1 GAuGYKPK 0 0 YLQLKKRLEDEFPGCLDI 0 0 GEGTPQVTGFFEVMVAGKLVHSKK 0 0 SGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_canFam Canis familiaris (dog) 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGCLDI 0 0 RGEGTPQATGFFEVTVAGKLVHSKK 0 0 RGDGYVDTESKFLRLVAAIKTALAQG* 0 >SEPW1_felCat Felis catus (cat) 0 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGCLDI 0 0 RGEGTPQATGFFEVMVGGKLVHSKK 0 0 RGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_bosTau Bos taurus (cow) 0 MAVVVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPSRLDI 0 0 RGEGTPQVTGFFEVFVAGKLVHSKK 0 0 GGDGYVDTESKFLKLVAAIKAALAQA* 0 >SEPW1_oviAri Ovis aries (sheep) 0 MAVVVRVVYC 2 1 GAuGYKPK 0 0 YLQLKKKLEDEFPSRLDI 0 0 CGEGTPQVTGFFEVFVAGKLVHSKK 0 0 GGDGYVDTESKFLKLVAAIKAALAQA* 0 >SEPW1_susScr Sus scrofa (pig) AF380118 0 MGVAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGRLDI 0 0 CGEGTPQVTGFFEVLVAGKLVHSKK 0 0 GGDGYVDTESKFLKLVAAIKAALAQG* 0 >SEPW1_eriEur Erinaceus europaeus (hedgehog) 0 MALAVRVVYC 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGCLDI 0 0 RGEGTPQGTGFFEVLVAGKLVHSKK 0 0 KGDGYVDTETKFLKLVTAIKAALAQG* 0 >SEPW1_sorAra Sorex araneus (shrew) 0 2 1 GAuGYKSK 0 0 YLQLKKKLEDEFPGCVDV 0 0 CGEGTPQVTGFFEVMVAGKLVHSKK 0 0 RGDGYVDSESKYVRLVTAIKTALAQA* 0 >SEPW1_choHof Choloepus hoffmanni (sloth) 0 MALAVRVVYW 2 1 GAuGYKPK 0 0 YVQLKKKLEDEFPGCLDI 0 0 SGEGTPQTTGFFEVMVAGKLVHSKK 0 0 QKGDGFVDTESKFLRLVAAIKAALAQG* 0 >SEPW1_monDom Monodelphis domestica (opossum) diverged 0 MAIQVRVVYW 2 1 GAuGYKPK 0 0 YLLLKKKLEDEYPGLLRH 0 0 NGEGTPEVTGFFEVTVAGKLVHSKK 0 0 AGHGFVDTADKYLQIVAEIKAALA* 0 >SEPW1_ornAna Ornithorhynchus anatinus (platypus) 0 MASLEAFPRGVVPVHVVYC 2 1 GAuGYKPK 0 0 FLQLKKKLENEFPGQVEI 0 0 SGEGTPQVTGWFEVTVAGKLVHSKK 0 0 EGDGFVDSESKFAKIRMAIKAALVPGY* 0 >SEPW_galGal Gallus gallus (chicken) tga confirmed 0 MPLRVTVLYC 2 1 GAuGYKPK 0 0 YERLRAELEKRFPGALEM 0 0 RGQGTQEVTGWFEVTVGSRLVHSKK 0 0 NGDGFVDTNAKLQRIVAAIQAALP* 0 >SEPW_anoCar Anolis carolinensis (lizard) 0 2 1 GAuGYSPK 0 0 YQQLKRGLEKEFPGKLEI 0 0 TGEGTPQVTGWFEVTVAGKLVHSKK 0 0 NGDGFVDNDTKLHKILMAIKAALA* 0 >SELW_xenTro Xenopus tropicalis (frog) tga confirmed 0 MPDTMVKVNVVYC 2 1 GAuGYLSK 0 0 FRRLKKELEQRFPGKLSI 0 0 DGEGTERMTGWFEVSINGKLVHSKK 0 0 NGDGYVDNDAKLQKIILAIEAALKQ* 0 >SEPW_danRer Danio rerio (zebrafish) tga confirmed 0 MTVKVHVVYC 2 1 GGuGYRPK 0 0 FIKLKTLLEDEFPNELEI 0 0 TGEGTPSTTGWLEVEVNGKLVHSKK 0 0 NGDGFVDSDSKMQKIVTAIEQAMGK* 0 >SEPW1_takRub 0 MGVTIRVEYC 2 1 GGuGYGPR 0 0 YEELARVVRAEFPDADVSGFVGRM 1 2 GSFEIQINEQLIFSKLETGGFPYEDD 0 >SEPW2_calMil Callorhinchus milii (elephantfish) 1 GAuGYEPRYQKLAIVIKDEFPDADVSGKVGRT 1 2 GSFEIEINGQLIFSKLETGGFPYEND 0 0 ISEAVQKANNGEELQKIENSRPPCVIL* 0 >SEPW_eptBur Eptatretus burgeri (hagfish) cdna BJ662449 tgn-sel tag-stop 0 MPLKIHVVYC 2 1 GSuGYASK 0 0 FRALKVKLDHEFPGKLEI 0 0 TSEGTPGLTGKFEVQVGEKLVHSKK 0 0 NGDGFVDSPEKLQKIFKAVENALKGQ* 0
DIO1: 50 vertebrate iodothyronine deiodinases
>DIO1_homSap Homo sapiens (human) iodothyronine deiodinase type I 4 exons chr1 uc001cwb.1
0 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQ 1
2 GNRPLVLNFGSCTuPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS 1
2 DGWAFKNNMDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYK 0
0 GKSGPWNYNPEEVRAVLEKLHS* 0
>DIO1_panTro Pan troglodytes (chimp)
0 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVHLSGQRCNIWEFMQ 1
2 GNRPLVLNFGSCTuPSFMFKFDQFKRLIEDFSSIADFLVVYIEEAHAS 1
2 DGWAFKNNMDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRILYK 0
0 GKSGPWNYNPEEVRAVLEKLHS* 0
>DIO1_ponPyg Pongo pygmaeus (orang_sumatran)
0 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTETGGLAPNCPVVRLSGQRCNIWEFMQ 1
>DIO1_macMul Macaca mulatta (rhesus)
0 MGLPQSGLWVKKLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWDFMQ 1
2 GNRPLVLNFGSCTuPSFMFKFDQFKRLIEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNMDIRNHRNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRILYK 0
0 GKSGPWNYNPEEVRAVLEKLYS* 0
>DIO1_macFas Macaca fascicularis (crab-eating macaque)
0 MGLPQSGLWVKKLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWDFMQ 1
>DIO1_macNem Macaca nemestrina (pigtailed macaque)
0 MVLPQSGLWVKKLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGPSCNIWDFMQ 1
>DIO1_calJac Callithrix jacchus (marmoset)
0 MGLPGPGLWLKRLWVLLEVAVHVAVGKVLLTLFPDRVKKNILAMGDKTGMTRNPNFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVHLSGQRCNIWDFMQ 1
2 GNRPLVLNFGSCTuPSFMFKFDQFKRLTEDFSSVADFLIIYIEEAHAS 1
2 DGWAFKNNVDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSELYAALPERLYIIQEGRILYK 0
0 GKSGPWNYNPEEVRDVLEKLHS* 0
>DIO1_otoGar Otolemur garnettii (bushbaby)
0 MGLPRPGLWLKRLWVFLEVAVHVAVGKMLLILFPDRVKSQILAMGQQTVMAKNPHFSHDNWIPTFLQHPVFLVCPEGPLQRLEDMTERGGLAPNCPVSASSGQKCNIWDFMQ 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLVEDFSSVADFLIIYIEEAHAS 1
2 DGWAFKNNVDIRTHRNLQDRLRAAHLLLARSPQCPVVVDTMENQSSQLYAALPERLYVLQEGRILYK 0
0 GKSGPWNYQPEEVRAVLEKFDN* 0
>DIO1_micMur Microcebus murinus (mouse_lemur)
0 MGLPCPGLWLKRLWVLLQVAVHVAVGKVLLTLFPERVMQHILSIGQKTGMARNPHFTPDNWVPTFFSTQYFWFVLKVRWQQLEDVTERGGLAPNCPVVRLSGQRCNIWDFMQ 1
>DIO1_tupBel Tupaia belangeri (tree_shrew)
0 RAGLWLKRLWVFLQLTVQVAVGKVLLTLFPERVKQHILALGQKTGIARNPNFAHDNWIPTFFSTQYFWFVLKVYWQRLEDTTEPGGLAPNGPVVHLSGQRCDIWDFMQ 1
2 GDRPLVLNFGSCTuPSFLFKFDQFKRLIEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVNIRNHQNLQDRLQAAHLLLDRSPQCPVVVDTMQNQSSQLYAALPERLYVLQEGRILYK 0
0 GKPGPWNYDPEEVRAVLEKLRS* 0
>DIO1_musMus Mus musculus (mouse)
0 MGLPQLWLWLKRLVIFLQVALEVAVGKVLMTLFPGRVKQSILAMGQKTGMARNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSGQKCNIWDFIQ 1
2 GSRPLVLNFGSCTuPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHAT 1
2 DGWAFKNNVDIRQHRSLQERVRAARMLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYK 0
0 GKAGPWNYNPEEVRAVLEKLCTPPRHVPQL* 0
>DIOI_ratNor Rattus norvegicus (rat)
0 MGLSQLWLWLKRLVIFLQVALEVATGKVLMTLFPERVKQNILAMGQKTGMTRNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSGQKCNVWDFIQ 1
2 GSRPLVLNFGSCTuPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHAT 1
2 DGWAFKNNVDIRQHRSLQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYK 1
0 GKPGPWNYNPEEVRAVLEKLCIPPGHMPQF* 0
>DIOI_speTri Spermophilus tridecemlineatus (squirrel)
0 MGLLRPGLWLKKLWILLLVIVEVAMGKVLMTLFPERATQNILAMGQKTGMTRNPQFSPDNWVPTFFSIQYFWFVLKVRWQRLEDKAELGGLAPNCPVIRLSGEKCNIWDFIQ 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLIEDFSPIADFLIIYIEEAHAS 1
2 1
0 * 0
>DIOI_dipOrd Dipodomys ordii (kangaroo_rat)
0 MELSRLGLWLKRLWIFLQVVVEVAMGKMLMILFPERVKKHILAMGQKTGMTRNPRFSPDNWVPTFFSTQYFWFVLKVRWQRLEDKAMYGGLAPNCSVISLSGQRCSIWDFMQ 1
2 GNRPLVLNFGSCTuTSFLFKFDQFKRLVEDFDSTADFLIIYIEEAHAS 1
2 DGWAFKNNVNISHHRNLQDRLQAAQLLLDQKPQCPVVVDTMENQSSQLYAALPERLYVLQEGRILYK 1
0 GKPGPWNYNPEEVRAVLEKLCT* 0
>DIOI_ochPri Ochotona princeps (pika)
0 MAWPQVRLWLRRLWVLVQVAVEVAVGKVLMTLFPERVKQSILAMGQKTGLAQNPLFTHDNWIPTFFSIQYFWFILKVRWQRLEDATQPGGLAPNCPVVCLSGQECHIWDFMQ 1
2 MTGNRPLVLNFGSCTuPSFLSKFNQFKRLIEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVDIRNHRNLQERLQAAHLLLPRSPQCPVVVDTMQNQSSQHYAALPERLYVLQQGRILYK 1
0 GQPGPWNYDPEEVRAVLLELHS* 0
>DIOI_cavPor Cavia porcellus (guinea_pig)
0 MGLTWPGLWLKRLWVLVQVAVEVAMGKVLMTLFPERIKKSILAMGEKTGMTRNPQFSHDNWIPTFFSTQYFWFILKVRWQRLEETAELGGLAPDCSVVCLSGEKRTIWDFMH 1
2 GNRPLVLNFGSCTuPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS 1
2 DGWAFKNNVDIRQHQNLQDRMRAAHLLLAKSPQCPVVVDTMQNESSQLYAALPERLYVQEGRILYK 1
2 GKSGPWNYNPEEVRGVLEKLHT* 0
>DIO1_oryCun Oryctolagus cuniculus (rabbit)
0 MGLPRPGLWLKRLWVLVQVAVEVAVGKVLMTLFPERVKQNILAMGQKTGIAQNPNFAQDSWIPTFFSTQYFWFVLKVRWQRLEDATEPGGLAPNCSVVRLSGQQCSIWDFMR 1
2 GNRPLVLNFGSCTuPSFLSKFDQFKRLIQDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVDIKNHRNLQDRLRAASLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVLRQGRILYK 0
0 GESGPWNYNPEEVRAVLEELHS* 0
>DIO1_canFam Canis familiaris (dog)
0 MGLPRPVLWLRRLWVLLQVAVQVAVGKVFLKLFPARVKQHIVAMNGNKPHFSYDNWAPTLYSMQYFWFVLKVQWQRLEDRTEPGGLAPNCPVVRLSGQRCNIWDFMQ 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLIEDFCSTADFLIIYIEEAHAS 1
2 DGWAFKNNVNIRTHQTLQDRLQAARLLLDRAPPCPVVVDTMRNQSSQFYAALPERLFVLQEGRILYK 0
0 GKPGPWNYHPEEVRAVLEKLHS* 0
>DIO1_ursArc Ursus arctos AM748338
0 VAMHVAVGKVLLILFPERVKQQVLAMNKKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLS
>DIO1_melUrs Melursus ursinus AM748341
AMHVAVGKVLLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLSG
>DIO1_ursAme Ursus americanus AM748339
AMHVAVGKVLLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLSG
>DIO1_ursMar Ursus maritimus AM748337
AMHVAVGKVLLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLSG
>DIO1_ailMel Ailuropoda melanoleuca AM748344
AMHVAVGKVFLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYGMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVQLSG
>DIO1_treOrn Tremarctos ornatus AM748343
AMHVAVGKVLLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVQLSG
>DIO1_helMal Helarctos malayanus AM748340
GKVLLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAPNCP
>DIO1_ursthi Ursus thibetanus AM748342
AMHVAVGKVLLILFPERVKQQVLAMNQKNPHFSYDNWLPTFYSMQYFWFVLKVRWQRLEDRTEPGGLAP
>DIO1_felCat Felis catus (cat)
0 MGLSQLGLWLRRLWVLFQVALQVAVGKVFLILFPSRVKQHIVAMNRKNPHFSYDNWAPTLYSVQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLSGQRCSIWDFMK 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLIEDFCSIADFLIIYIEEAHAS 1
2 DGWAFKNNVNIRNHRNLQDRLQAACLLLDRSPRCPVVVDTMKNQSSRLYAALPERLYVLQAGRILYK 0
0 GKPGPWNYHPEEVRAVLEKLHS* 0
>DIO1_equCab Equus caballus (horse)
0 MGLPRAGLWLKRLWVLLQVALQVAVGKVLLTLFPDRVKQHIVAMNQKNPHFSYDNWVPTLYSTQYFWFVLKVHWQRLEDTTKRGGLAPNSPVVRLSGQRCNIWDFMQ 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLIEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVVIRNHRNLQDRLRAARLLLDRSPPCPVVVDSMENRSSQLYAALPDRLYVLQARRILYK 0
0 GKPGPWNYHPEEVRAVLEKLHS* 0
>DIO1_myoLuc Myotis lucifugus (microbat)
0 MGLPQPGLWLKRLWILLQVALHVTLGKVQLKLFPRRVKQHILAMNRKNPHFSYDNWAPTLFSTPYFWFILKVRWQRLEDKTEEGSLAPNCPVVRLSGQRCHIWDFMQ 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLIEDFSAIADFLVIYIEEAHAS 1
2 DGWAFKNNVVIKNHRNLQDRLQAAHLLLDRSPRCPVVVDTMKNQSSQLYAALPDRLYVLQEGRILYK 0
0 GKPGPWNYHPEEVRAVLEKLRS* 0
>DIO1_pteVam Pteropus vampyrus (macrobat)
0 MELPWPGRWLKRLWVLLQVALHVAVGKVQLTLFPRRVKQNIVAMNRKNPHFSFDNWLPTLFSTQYFWFVLKVRWQQLEDTTKEGGLAPNCPVVCLSGQRCNIWDFMQ 1
2 GKRPLVLNFGSCTuPSFLLKFDQFKKLIEDFSSIADFLVIYIEEAHAS 1
2 ERLQAARMLLDRSPPVPVVVDTMKNQSSHLYAALHERLYVLQEGRILYK 0
0 GKPGPWNYHPEEVHAVLEKLHS* 0
>DIO1_bosTau Bos taurus (cow)
0 MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQ 1
2 GNRPLVLNFGSCTuPSFIFKFDQFKRLIEDFGSVADFLIIYIEEAHAS 1
2 DGWAFKNNVDIKNHRNLQDRLRAAHLLLDRSPPCPVVVDTMTNQSSSCYAALPERLYVLQEGRVLYK 0
0 GKPGPWNYHPEEVRAVLEKLHS* 0
>DIO1_turTru Tursiops truncatus (dolphin)
0 MGLPLPGLWLKRLWVLFQVGLHVAMGKVLLTLFPRRVKQNILAMSEKTGMAKNPHFSYENWIPTFFSAQYFWFILKVRWQRLEDMTEQGGRAPNCPVVRLSGQRCNIWDFMQG 1
2 GNRPLVLNFGSCTuPSFIFKFDQFKRLIEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVDIKNHQHLQDRLRAARLLLDRSPQCPVVVDTMKNQSSQLYAALPERLYVLQDGRILYK 0
0 GKPGPWNYRPEEVRAVLEKLHS* 0
>DIO1_susScr Sus scrofa (pig)
0 MELPLPGLWLKRLWVLFQVALHVAMGKVLMTLFPGRVKQDILAMSQKTGMAKNPHFSHENWIPTFFSAQYFWFVLKVRWQRLEDKTEEGGLAPNCPVVSLSGQRCHIWDFMQ 1
2 GNRPLVLNFGSCTuPSFIFKFDQFKRLIEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVDIKNHQNLQDRLRAAHLLLDRSPQCPVVVDTMKNQSSRLYAALPERLYVLQAGRILYK 0
0 GKPGPWNYHPEEVRAVLEKLHS* 0
>DIO1_vicVic Vicugna vicugna (vicugna)
0 MGLSLPGLWLKRLWVLFQVVLHVALGKVLLTLFPGRVKQDILAMSQRTGMAQNPHFSYENWIPTFFSTQYFWFILKVRWQRLEDTTEQGGLAPDCPVVCLSDRVHIWDFMQ 1
2 FDQFKRLIEDFNSIADFLIIYIEEAHAS 1
2 DGWAFKNNVDIKNHRNLQDRLRAAHLLLDRSPQCPVVVDTMKNQSSQLYAALPERLYVLQKGRILk 0
0 GKPGPWNYHPEEVRAVLEKLHS* 0
>DIO1_eriEur Erinaceus europaeus (hedgehog)
0 MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQ 1
2 1
2 DRWAFKNNVDIRTHRNLQDRMRAALLLLDRDPQCPVVVDTMENQSSQLYAALPERLYVLQEGRILYK 0
0 GKPGPWDYQPQEVRAVLEKLRGKCGQTLPKL* 0
>DIO1_sunMur Suncus murinus (shrew)
0 MGLPGLGLLLKRFGVLVRVALKVAVGKVLLTLWPSAIRPHLLAMSEKTGMAKNPRFTYEDWAPTFFSTQYFWFVLKVNWQQLEDRTKQGDIAPDSPVVHLSGQRARLWDFMQ 1
2 GNRPLVLNFGSCSuPSFLFKFDQFKRLVEDFSSVADFLTVYIEEAHAS 1
2 DGWAFKNNVDIRRHRDLQERLQAARLLLDRNPGCPVVVDTMENRSSQLYAALPERLYVLQEGRILYK 0
0 GGPGPWNYHPEEVHAVLEQLCRSSAQSPRL* 0
>DIO1_loxAfr Loxodonta africana (elephant)
0 MGLPQPGLWLKRLWIFLKVALHVAMGKVLLILFPGRVKKNILAQNPHFAYDMWGSTLFSIPYFWFILKVYWQRLEDKTEEGGPAPDCPVVCLSGQRCNISDFMQ 1
2 GIRPLVLNFGSCTuPSFLSKLDQFKRLVEDFSSMADFLIIYIEEAHAT 1
2 DGWAFKNNVAIRNHRNLQDRLQAAHLLLDRSPQCPVVVDTMQNVSSQLYAALPERLYVLQEGRILYK 0
0 GKPGPWNYHPEEVRAVLEKLNS* 0
>DIO1_proCap Procavia capensis (hyrax)
0 MGLPQPVLWLKRLWVLLRVALHVAMGKVLLALFPGRVKKNILAQNPHFAYDMWCSTLFSVPYFWFVLKVYWQRLEDKTEEGGLAPNCPVVHLSGQRRNIWDFMQ 1
2 GIRPLVLNFGSCTuPSFLSKLDQFKRLVEDFSSMADFLIIYIEEAHAT 1
2 DGWAFKNNVAIRTHRNLQDRLQAARLLLDRSPQCPVVVDTMQNVSSQFYAALPERLYVLQEGRILYK 0
0 GKPGPWNYHPEEVRAFLEKFGS* 0
>DIO1_echTel Echinops telfairi (tenrec)
0 1
2 GTRPLVLNFGSCT*PSFLLKFDQFKRLMDDFHATADFLI 1
2 DGWAFKNNVTIRTHQNLEDRLRAARLLLDRGPQCPVVVDTMENESGRLYAALPERLYVLQEGRILYK 0
0 GKPGPWNYRPEEVRAVLEKLDS* 0
>DIO1_choHof Choloepus hoffmanni (sloth)
0 MGLSWPGLWLKRLWVLLQVALHVAMGKILLTLFPGRVKQNILAMSRRANNTKDPQFPYDNWGPTFFNTQYFWFVLKVRWQRLEDKTEQGGLAPNCPVVHLSRQRCNIWDFMQG 1
2 GNRPLVLNFGSCTuPSFLFKLDQFKRLVDDFSSIADFLIIYIEEAHAS 1
2 RRRAARLLLDRSPQCPVVVDTMQNQSSQLYAALPERLYMLQEGRILYK 0
0* 0
>DIO1_dasNov Dasypus novemcinctus (armadillo)
0 MGLSQPGLWLKRLWILFQVALHVAVGKTLLTLFPGRVKQNILAKSQKSHKAENPHFPYDNWGPTFFNTQYFWFLLKIGWQRLEDKTEQGGLAPNCPVVHLSGQRCNIWDFMQ 1
2 GNRPLVLNFGSCTuPSFLFKFDQFKRLVEDFSSIADFLIIYIEEAHAS 1
2 DGWAFKNNVDIRNHRNLQDRQRAACLLLDRSPQCPVVVDTMQNQSSQLYAALPDRLYVLQEGRILYK 0
0 GKPGPWDYQPEEVRAVLETLNG* 0
>DIO1_monDom Monodelphis domestica (opossum)
0 MAELLRLWLWLWLRLQRLWVLLQVVGHVLMGKLMKMLSPDRMKQHILGMGQKSSIFQNPNFKYENWGPTFFTLPYFLFVLRVRWQRLEDQALQGGPAPDCPVVSLRGQPRRLWDFMH 1
2 ANRPLVLSFGSCTuPSFIFKFDQFHRIMEDFSSVADFLIIYIEEAHAT 1
2 DGWAFANNIDIKQHRTLQDRMEAARLLMDRKPLCPIVVDTMDNLATRKYAALPERFYILLEGHILYK 0
0 GGPGPWSYNPEEVRAVLETLSR* 0
>DIO1_triVul Trichosurus vulpecula (possum)
0 MAGPLLWVRRFWALLQVAFHVVVGKLLKTLFPNMMKKHILSLGQRSSISQNTQFAYENWGPTFFSIQYFFFVLKVRWQRLEDQALQGGLAPNPPVVTLKGESRHIWDFMH 1
2 GNRPLVLNFGSCTuPSFILKFDQFRKLIEDFSSIADFLIIYIEEAHAA 1
2 DGWAFENNIDIKQHRTLQDRRETAQLLMDRKPLCPIVLDTMDNLTSKKYAALPERFYVLLEGRILFK 0
0 GDPGPWNYHPEEVQAVLQ* 0
>DIO1_ornAna Ornithorhynchus anatinus (platypus)
0 1
2 GSRPLVLTFGSCTuPSFLFKFDQFNQLVQDFNSIADFLIIYIEEAHPT 1
2 DGWAFANNVDIPSHRSLQERQEAARRLLARGPRCPVVVDTMDNASSRQYAALPERLYLLREGKVVYK 0
0 GGPGPWNYNPGEVRAVLEKLS 0*
>DIO1_galGal Gallus gallus (chicken)
0 MLSIRVLLHKLLILLQVTLSVVVGKTMMILFPDTTKRYILKLGEKSRMNQNPKFSYENWGPTFFSFQYLLFVLKVKWRRLEDEAHEGRPAPNTPVVALNGEMQHLFSFMR 1
2 DNRPLILNFGSCTuPSFMLKFDEFNKLVKDFSSIADFLIIYIEEAHAV 1
2 DGWAFRNNVVIKNHRSLEDRKTAAQFLQQKNPLCPVVLDTMENLSSSKYAALPERLYILQAGNVIYK 0
0 GGVGPWNYHPQEIRAVLEKLK* 0
>DIO1_anoCar Anolis carolinensis (lizard)
0 MFKAGRLVLKTWLLLQVCLSTAVGKLFMILFPATAKRYILKQSERSSMGRNPNFVYENWGPTFFSFQYLLFVLKVKWKRLEDKALQGCPAPNTPVVDFDGKIHHILDFMQ 1
2 DNRPLVLAFGSCTuPSFMFRFGEFKKLIEDFSFAADFLVIYIEEAHAS 1
2 DGWAFKNNIVIKSHRTLHDRMQAAEILLKQYPLCSVVMDTMENLSSSTYAALPERLYVLQGGNIVYK 0
0 GGVGPWNYNPQEVREVLEKL* 0
>DIO1_xenTro Xenopus laevis (frog) tga confirmed
0 MLRYIQKALILFFLFLYVVVGKVLMFLFPQTMASVLKSRFEISGVHDPKFQYEDWGPTFFTYKFLRSVLEIMWMRLEDEAFVGHSAPNTPVVDLSGELHHIWDYLQ 1
2 GTRPLVLSFGSCTuPPFLFRLGEFNKLVNEFNSIADFLIIYIDEAHAA 1
2 DEWALKNNLHIKKHRSLQDRLAAAKRLMEESPSCPVVLDTMSNLCSAKYAALPERLYILQEGKIIYK 0
0 GKMGPWGYKPEEVCSVLEKKK* 0
>DIO1_danRer Danio rerio (zebrafish)
0 MGSAVGFALRKLFVYISAVLMVCAAILQMSMLKLLSFISPGRMRKIHMKMGERSTMTQNPKFRYEDWGPAFFSLAFIKTLFFVNWCSLGLEAFEGHAAPDSALITLDRQKTSVHRFLK 1
2 GNRPLVLSFGSCTuPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHAT 1
2 DAWAFKNNVDISVHKNLEERLAAARTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIY 0
0 QASDLGGQA* 0
>DIO1_takRub Takifugu rubripes (fugu) genome glitches
0 MLLQKLAMYLSTAGLFCFMITLNVVLWILNIVAPALAKKIALKMGEKATMTQDPLFKYEDWGLTFASTALVKTASRHMWLSLGQEAFAGLEAPDSPVVTMERKRSSIGEFMK 1
2 TNRPLVLNFGSCTuPPFMFKLEEFKQLVRDFSDVADFLVVYIAEAHST 1
2 DGWAFKNNFDINQHRNLEDRLSAAQILVQKDPLCPVVVDDMNNSCAIKYGALPERLYVLQAGKVLYK 0
0 GAVGPWGYDPREVRSYLEKMK* 0
>DIO1_calMil Callorhinchus milii (elephantfish) weak match but introns ok
0 MWRRVVVYMQTVLLLVCICVRVAVGRVMLTLFPATTRRLELRNGLKTTMTLNPRFRFEDWGPSMFSLSSLRAVTTSIIANSGDRAFPGQPAPDTTLIDLDNTAHTIRSFIR 1
2 1
2 0
0 SGLGPWGYKPEEVRGVLHTLE* 0
DIO2: 27 vertebrate iodothyronine deiodinases
>DIO2_homSap Homo sapiens (human) iodothyronine deiodinase type II 2 exons chr14 uc001xuu.1 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSSAEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATuPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDG WAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRuKKTRLAG* 0 >DOI2_macMul Macaca mulatta (rhesus) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSSAEGGDNSGHGTQEKIAEGAACHLLDFASPERPLVVNFGSATuPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDG WAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRuKKTRLAG* 0 >DOI2_otoGar Otolemur garnettii (bushbaby) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQ 0 0 VKLGEEAPNSSVVHVSNPEKGDSSGNGAPENAAAECHLLDFASPERPLVVNFGSATuPPFTSQLPAFRKLVEEFSAVADFLLVYIDEAHPSDG WAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFFYNLQEVRRWLEKNFSKRuNRLAG* 0 >DOI2_tupBel Tupaia belangeri (tree_shrew) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSNLEGGHNGGNGTQEKTADGAECHLLDFANSERPLVVNFGSATuPPFTSQLPAFSKLLEESSVADFLVVYIDEAHPSDG WAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFYYNLQEVRRWLEKNFSKRuNSLAG* 0 >DIO2_ratNor Rattus norvegicus (rat) 0 MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECHLLDFACAERPLVVNFGSATuPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDG WAVPGDSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRuILD* 0 >DOI2_canFam Canis familiaris (dog) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGMRCIWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSNSEGGDNSRNGAQVKIVDGAECHLLDFASPERPLVVNFGSATuPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGD SSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFYYNLQEVRRWLEKNFSKRuNRLAG* 0 >DOI2_bosTau Bos taurus (cow) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGMRCIWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASPERPLVVNFGSATuPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGD SSLFFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFFYNLQEVRRWLEKNFSKRuKRLAG* 0 >DIO2_susScr Sus scrofa (pig) tga tag 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGMRCIWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSNPEGSNNHGHGTQEKTVDGAECHLLDFANPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDG WAVPGDSSLSFEVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFYYNLQEVRRWLEKNFSKRuKLD* 0 >DOI2_equCab Equus caballus (horse) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGMRCIWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSNPDRGDNRGNGAQGKTVDGTECHLLDFASSERPLVVNFGSATuPPFISQLPAFSKLVEEFSSVADFLLVYIDEAHPSDG WAVPGDSSLSFEVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFYYNLQEVRRWLEKNFSERuNKLG* 0 >DOI2_sorAra Sorex araneus (shrew) 0 MGNLSVHLLITLQILPVFFSNCLFLALYDSVILLKHVVLMLSRSKSTRGEWRRMLTSEGMRCIWKSFLLDAYKQ 0 0 VKLGEDAPNSSVVHVSSSEDGSRNGAHEKTVDGAECHLLDFASPERPLVVNFGSATuPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDG WAVPRDSSLSFEVKKHRSQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFCYNLQEVRDWLEKNFSKRuNSL* 0 >DOI2_echTel Echinops telfairi (tenrec) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVLLLKHVMLLLSRSKSTCGEWRRLLTFEGLRCVWKSFLLDAYKQ 0 0 VKLGEDAPNSGVVHVSNFEGGGNRGPGAQEKTADGAQCHLLDFARAERPLVVNFGSATuPPFTSQLPAFSQLVEEFSSVADFLLVYIDEAHPSDG WAVPGDSSSSFEVKKHRNQEDRCAAAHRLLERFSLPPQCLVVADRMDNNANVAYGVAFERVCIVQQKIAYLGGKGPFCYNLQEVRCWLEKNFSKRuTRVAGQ* 0 >DOI2_dasNov Dasypus novemcinctus (armadillo) 0 MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQ 0 0 VKLGEDAPNSGVVHVSNPEGGDNSGNSAQEKTEDGAECHLLDFASPERPLVINFGSATuPPFTSQLPAFSKLIEEFSSVADFLLVYIDEAHPSDG WAVPGGSSLSFEVKKHRNQEDRCAAVHKLLDRFSLPPQCHVVADRMDNNANIAYGVAFERVCIVQRQKIVYLGGKGPFCYNLQEVQHWLEKNFSKRuNRLAG* 0 >DOI2_monDom Monodelphis domestica (opossum) tga tag 0 MGLLSIDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQ 0 0 VKLGGDAPNSSVIHITSAEVGSGQQNNSRWKRFDGAECHLLDFANPERPLVVNFGSATuPPFTSQLPAFSKLVEEFSTVADFLLVYIDEAHPSDG WAVPGNSSVSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANIAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEKNFSKRuNPG* 0 >DIO2_ornAna Ornithorhynchus anatinus (platypus) tga tga then tag 0 MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWNSFLMDAYKQ 0 0 VKLGGDAPNSSVVHVANANGETSGGNSPKWKNFSGRYGAECHLLDFASSERPLVVNFGSATuPPFISQLPAFSKLVEEFSAVADFLLVYIDEAHPSDG WAVPGEFSLPFEVRKHQNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEQNFSKRuNPD* 0 >DIO2_galGal Gallus gallus (chicken) 2 exons 0 MGLLSADLLITLQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEGLRCVWNSFLLDAYKQ 0 0 VKLGGEAPNSSVIHIAKGNDGSNSSWKSVGGKCGTKCHLLDFANSERPLVVNFGSATuPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDG WAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEQNFSKRuNPLSTEDLSTDVSL* 0 >DIO2_anoCar Anolis carolinensis (lizard) 0 MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEGLRCVWNSFLLDAYKQ 0 0 VKLGGEAPNSSVIHIAKGNDGSNSSWKSVGGKCGTKCHLLDFANSERPLVVNFGSATuPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDG WAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEQNFSKRuNPLSTEDLSTDVSL* 0 >DIO2_xenTro Xenopus tropicalis (frog) tga tag 0 MGLLSVDLLITLQILPGFFSNCLFLALYDSVVLVKHVLLQLSRSKSSQSQWRRMLTPEGLRCVWNSFLLDAYKQ 0 0 VKLGQDAPNSNVIQVSNKICKSVQRKLVGKCHLLDFASSERPLVVNFGSATuPPFISQLPAFSKLVEEFSSVADFVLVYIDEAHPSDG WAAPGTTSYEVKKHRNQEERCAAASKLLEHFSIPPQCQVVADCMDNNANVAYGVSFERVCIVQKQKIVYLGGKGPFFYNIQEIRRWLELSFGKRuT* 0 >DIO2_neoFor Neoceratodus forsteri (lungfish) exons unknown 0 MGLLSVDLLITLQILPWFFSNCLFLALYDSVVLLKHVILLLSCSKSSRGEWRRMLTSEGLRTVWNSFLLDAYKQ 0 0 VKLGGDAPNSKVVRVTSGCCRRRSFSGKGESECHLLDFASSNRPLVVNFGSATUPPFISQLPTFRKLVEEFSDVADFLLVYIDEAHPADG WAAPGVATKSFEVKKHRSQEERCVAAHKLLEHFSLPPQCQVVADCMDNNTNVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLKEVRHWLEQTYRKRuVPTCELIM* 0 >DIO2_gasAcu Gasterosteus aculeatus (stickleback) cDNA taa stop 0 MGMASGGLRVTLQILPGFFSNCLFLALYDSVVLLKAVVSLLSCSRAAGRGARRRMLTSAGLRSVWRSFLLDAYKQ 0 0 VKVGLEAPNSKVVKVPGSPQRSSNLSNLISLPPGAMIANEVECHLLDFESSDRPLVVNFGSATuPPFISHLPAFRQLVEDFSDVANFLLVYIDEAHPSDG WVAPALGSCSFDVPKHQNLEERLGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVSNERVCIVKQRKIAYLGGQGPFFNLKDVQHWLEQNFGKRFSRTSAEKDMSHISKKGIIHQ* 0 >DIO2_oryLap Oryzias latipes (medaka) tga stop 0 MGSAGAELLVTLQILPGFFSNCLFMALYDSVVLLKRVVSLLSCSRSVSCGEWRRMLTSAGLRAIWNSFLLDAYKQ 0 0 VKVPESPRWSSSIKSMTSVPRGARAQTGDECRLLDFESSDRPLVVNFGSATuPPFISHLPAFRQLVEDFSDVANFLLVYIDEAHPSDG WVAPQMGPCSFSFRKHQNLEERMGAARQLTEHFSLPPQCQLVADCMDNNANVAYGVSNERVCIVHQRKIAYLGGKGPFFYNLKEVRQWLEQLRQTVGPNTEE* 0 >DIO2_danRer Danio rerio (zebrafish) cDNA tga taa 0 MGLLSVDLLVTLQILPGFFSNCLFFVLYDSIVLVKRVVSLLSCSGSTGEWQRMLTTAGVRSIWNSFLLDAYKQ 0 0 VKLGEAAPNSKVVKVTGINRCWSISGKTHNQCHLLDFESPDRPLVVNFGSATuPPFISQLPVFRRMVEEFSDVADFLLVYIDEAHPSDG WVGPPMENFSFEVRKHRNLEERMFAARTLLEHFSLPPQCQLVADCMDNNANIAYGVSYERVCIVQKNKIAYLGGKGPFFYNLKDVRRWLEKCYGKu* 0 >DIO2_tetNig Tetraodon nigroviridis (pufferfish) tag 0 MGMASEDLLITLQILPGFFSNCLFLALYDSVVLVRRVVSRLSCSRSAGAKEWRPMLTSAGLRSIWNSFLLDAYKQ 0 0 VKVPNGPRWSSISNMLPGANLRNGIECHLLDFESSNRPLVVNFGSATuPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDG WEAPPMGPCSFNVRKHQNLEERLGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVSNERVCIVQQRKIAYLGGKGPFFYNLKEVRQWLEHSYGKR* 0 >DIO2_takRub Takifugu rubripes (fugu) taa 0 MGMASEDLLITLQILPGFFSNCLFLALYDSVVLVRRVVSRLSCSRSAGPKEWRPMLTSAGLRSIWNSFLLDAYKQ 0 0 VKLGCEAPNSKLVKVPDGARWSSINNITNMLPGASLCNGIECHLLDFESSNRPLVVNFGSATuPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSD GWKAPPMGPISFNVRKHQNLEERIGAAQKLIEHFSLPPQCQLVADCMDNNANVAYGVSNERVCIVQQRKITYLGGKGPFFYNLKEVRQWLEQSYGPHLI* 0 >DIO2_funHet Fundulus heteroclitis tag tag 0 MGSASEDLLVTLQILPGFFSNCLFLALYDSVVLVKRVVALLSRSRSAGCGEWRRMLTSEGLRSIWNSFLLDAHKQ 0 0 VKLGCEAPNSKVVKVPDGPRWSSTVVPCGSRIQTGGECRLLDFESSDRPLVVNFGSATuPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDG WVAPQMGACSFSFRKHQNLEERIGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVANERVCIVHQRKIAYLGGKGPFFYSLKDVRQWLELSYGRR* 0 >DIO2_calMil Callorhinchus milii (elephantfish)no intron tga stop many extra aa subsequent 0 MGLLSMDLIMKLQILPGFSNCLFLAAYDSFVLLRQAVSLLSCSGLGPDPQHRMLTAEGMQVVWQSFLLDALKQ 0 0 VKVGLEAPNSAVARLDGGAPCRLLDFASRDRPLVVNFGSATuPPFVSRLPAFRQMVERYAEVADFLLVYVDEAHPSDGWALRSRFQLRRHRSQEER CSAAGLLAREFGLPAACGVVADLMDNNANRAYGVAFERLCVVQSQKIAYLGGKGPFFYNLNGVREWLERHSGQRWG* 0 >DIO2a_petMar Petromyzon marinus (lamprey) 0 MTAELNVSVFVALRILPGFFTNCLFLGLRDVLALLARSTRALFARHVPASCCPCPPEACRRVLTRAGMRAVWRSFLLDARRE 0 0 AQRAGDPAPNPRVALLADARSSSPAAAAAIPCRLQELSREGRPLVINMGSASuPPFVGRLPEFRRVVDDFSHAADFLLVYVEEAHPSDGWAVPGALQVSRARSLENNNSMA >DIO2b_petMar Petromyzon marinus (lamprey) frag 0 SRPVVDSLLILPGVFSNCLFLALYDAVSFLRRALQASLTHSAKGDAQHPRMLAGQGMLSVWRSYVLDAHKK VRLGGEAPNSSV RPSPPQPPPPQLRQAPPCRLLDFARAHRPLVVNFGSASuPPFVEQLGEFCDLVRDFADVADFLVVYIEEAHPSDAWPAPGGLEVPRHLALGDRCVAASQLRGLMPPLGRCPVVADAMDNNANIDYGVSYERLYVIQDG RIRYLGGKGPFFYRVREVKSFLESVKASR* 0
DIO3: 36 vertebrate iodothyronine deiodinases
>DIO3_homSap Homo sapiens (human) 1 exon chr14
0 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYAQGNRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRRV* 0
>DIO3_macMul Macaca mulatta (rhesus)
0 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQRILDYAQGNRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRRV* 0
>DIO3_musMus Mus musculus (mouse)
0 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPHRF* 0
>DIO3_ratNor Rattus norvegicus (rat)
0 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPRRL* 0
>DIO3_cavPor Cavia porcellus (guinea_pig)
0 MLRSLLLHSLRLCAQIASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRGLGQPEPEAELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQRILDYEHGNRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGPRHGRF* 0
>DIO3_canFam Canis familiaris (dog)
0 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPAVELDSDGEELPPDDPPVCVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPNGFQNQHILDYARGNRPLVLNFGS
CTuPPFMARMSAFHRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAAQVLQQGAPSCSLVLDTMANSSSSAYGAYFERLYVIQNGTVMYQGGRGPDGYQVSELRTWLERYDEQLHGAQPRRV* 0
>DIO3_felCat Felis catus (cat)
0 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPAAELDSDGEEVPPDDPPVCVSDDNRLCTLASLKAVWHGQKuDIFKQAHEGGPAPNSEVVLPNGFQNQHILDYARGNRQLVLNFGR
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAAEVLQQGAPSCSLVLDTMANSSSSAYGAYFERLYVVQNGTIMYQGGRGPDGYQVSELRTWLERYDAQLRGGQPRRV* 0
>DIO3_bosTau Bos taurus (cow)
0 MLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVELNSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQNQHILDYARGNRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQSGTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRRV* 0
>DIO3_susScr Sus scrofa (pig)
0 MLHSLLLHSLRLCAQTASCLVLFPRFLGTACMLWLLDFLCIRKHLLGRRRRGEPETEVELNSDGDEVPPDDPPICVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQNQHILDYARGNRPLVLNFGS
CTuPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECSLVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDQQLHGPQPRRV* 0
>DIO3_loxAfr Loxodonta africana (elephant)
0 MLRCMLLHSLRLCAQTASCIVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPETEVELNSDGEEVPPDDPPISVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQRILDYVRGNRPLVLNFGS
CTuPPFMARMSAFQRLVTKYRRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQNGTIVYQGGRGPDGYQVAKLRTWLERYDEQLHSAQTRRV* 0
>DIO3_echTel Echinops telfairi (tenrec)
0 MLRSPVLHSLVLCAQDAYSIVLFPCLLGTAFMQRQDFLCIRKHFLGLRRRGQPEPEVELNSDGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYARGSRPLVLNFGS
CTuPPFMARMSAFQRLVSKYRGEVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAARVLQQGAPDCALVLDTMTNSSSSAYGAYFERLYVIQNGTVMFQGGRGPDGYQVAELRTWLQQYSEQQHRAQPRRV* 0
>DIO3_monDom Monodelphis domestica (opossum) tga taa
0 MRSRREGDTEEPRKAGKGGGGGMGDEEDGAAVIQSPGLPPDDPPVWVSDSNRLCTLESLKAVWHGQKMDFFKTARKGSLAPNPEVIQLDGLKRLRILDFARGSRPLVLNFGS
CTuPPFMARLRAFQRLASTFLDIADFLLVYIEEAHPSDGWVSSDAAYDIPKHQCLQDRLRAARLLQEGVPGCLLAVDTMDNASSAAYGAYFERLYIIQDARVMYQGGRGPEGYKISELRHWLDQYKDRLQSPEASVVLPV* 0
>DIO3_ornAna Ornithorhynchus anatinus (platypus)
DCLLVYIEEAHPSDGWVSSDAPYDIPKHRCLQDRLRAARLMQRGAPGCRLAVDTMDNAASAAYGAYFERLYVVQDARVVYQGGRGPEGYKISELRLWLEQYRLRLRGPGPATAAAAAVLDV* 0
>DIO3_galGal Gallus gallus (chicken)
0 MLHSLGAHTLQLLTQAAACILLFPRFLLTAVMLWLLDFLCIRKKMLTMPTAEEAAGAGEGPPPDDPPVCVSDSNRMFTLESLKAVWHGQKLDFFKSAHVGSPAPNPEVIQLDGQKRLRILDFARGKRPLILNFGS
CTuPPFMARLRSFRRLAADFVDIADFLLVYIEEAHPSDGWVSSDAAYSIPKHQCLQDRLRAAQLMREGAPDCPLAVDTMDNASSAAYGAYFERLYVIQEEKVMYQGGRGPEGYKISELRTWLDQYKTRLQSPGAVVIQV* 0
>DIO3_xenTro Xenopus laevis (frog)
0 MLHCAGPHTGKLVKQVAACCLLLPRFLLTGLMLWLLDFQCIRRRVLLTAREESTAEHEDPPLCVSDSNRMCTVESLRAVWHGQKLDYFKSAHLGCSAPNTEVVMLEGRRLCKILDFSQGKRPLVVNFGS
CTuPPFMARLQAYRRLAAQHVGIADFLLVYIEEAHPSDGWLSTDASYQIPQHQCLQDRLAAAQLMLQGAPGCRVVVDTMDNSSNAAYGAYFERLYIVLEGKVVYQGGRGPEGYKISELRMWLEQYQQGLMGTKGSGQVVIQV* 0
>DIO3_ranCat Rana catesbiana (bullfrog)
0 MLPAPHTCCRLLQQLLACCLLLPRFLLTVLLLWLLDFPCVRRRVIRGAKEEDPGAPEREDPPLCVSDTNRMCTLESLKAVWYGQKLDFFKSAHLGGGAPNTEVVTLEGQRLCRILDFSKGHRPLVLNFGS
CTuPPFMARLQAYQRLAAQRLDFADFLLVYIEEAHPCDGWLSTDAAYQIPTHQCLQDRLRAAQLMLQGAPGCRVVADTMTNASNAAYGAYFERLYVILDGKVVYQGGRGPEGYKIGELRNWLDQYQTRATGNGALVIQV* 0
>DIO3_neoFor Neoceratodus forsteri (lungfish) 1 exon
0 MYQSSGVHTMNEVLKQAFACFILLPRFLVTALMLWLLDFLCVRRRVLLHMSRRQEASDLPDEPELCVSDSNRMFTLKSLRAVWHDQKLDFFKAAHIGLVAPNTEVIKLEGQRKAKILEFGGGKRPLILNFGS
CTuPPFMARLKAFRGVATQYKDVADFLLIYIEEAHPSDGWVSTDAPYQIPKHQCLEDRLKAAQLMNLEIPGCLVVVDTMDNASNAAYGAFFERLYIVQQERVVYQGGRGPEGYKISELKNWLDQYKSQLQNSSAVVIQV* 0
>DIO3a_danRer Danio rerio (zebrafish)
MEMLQGSAGVQSALKNAAVCVLLLPRFLLAALMLCLLDFLCIRRKLLLKMQEGAFSSPDDPPLRVSDSNKMFTLESLRAVWYGQKLDFFKSARLGGAAPNTEVFPLDGDARAAERILDYARGRRPLILNFGS
CS*PPFMTRLSAFQRVARQYADIADSLLVYIEEAHPSDGWVSSDAPVQIPRHRCLEDRLRAAQMLHREAAGSAVVVDSMQNSCNAAYGAYFERLYIVKDATVVYQGGRGPEGYRIAELRDWLERYRSGLQESAVLHV* 0
>DIO3bb_danRer Danio rerio (zebrafish)
0 MNTGRALKNALVCLLILPRFLVAAFMLWCLDFLCVRKRVLVHLQERAEEEEEDAEEEEEPLCISDSSRMFSWESLKAVFHGHKLDYMKSARLGHAAPDSEVFPLAEPRRGRVLEFARGHRPLVLSFGS
CSuPPFMRRLKAFRRLVLRYADVADALLIYIEEAHPSDGWRSSDAPHQIRRHRSLEERLSAARLMEREAPGCAVVADGMENAANSAYGAYFDRLYIVQDGRVVYQGGRGPEGFRISELRHWLDRYRERLRDAVIPV* 0
>DIO3bbb_danRer Danio rerio (zebrafish) bizarre ... matches opossum yet in both genomes
VHTLGFLTQVAACCFLGPRFLATAVTLWLLDFLCIRKKVLMRHRREGDAEDPDDPPIWVSDSNRFCTIESLKAVWHGQKMDFFKTAHKGSPAPNPEVIQLDGLKRLRILDFARGSRPLVLNFGS
CTuPPFTARLRAFQHLASTFLDIADFLLVYIEEAHPSDGWVTSDAAYDIPKHQCLQDRLRAARLLQEGAPGCLLAVDTMDNASSAAYGAYSERLYIIQEARVMYQGGRGPEGYKISELRHWLDQYKDRLQSPPASVVLPV* 0
>DIO3b_danRer Danio rerio (zebrafish)
0 GALKNALVCLLILTRFLVAAFMLWCLDFLCVRKRVLVHLQERAYAEQEEEPLCISDSSRMFSWESLKAVFHGHKLDYMKSARLGHAAPDSEVFPLAEPRRGRVLEFARGHRPLVLSFGS
CSuPPFMRRLKAFRRLVLRYADVADALLIYIEEAHPSDGWRSSDAPHQIRRHRSLEERLSAARLMEREAPGCAVVADGMENAANSAYGAYFDRLYIVQDGRVVYQ* 0
>DIO3a_takRub Takifugu rubripes (fugu) 1 exon
0 MLDSGGVQMATALKHAALCLMLLPRFLLTAVMLWLLDFLCIRRKVLLQMGQRQKSPDDPPVCVSDSNRMFTLESLGAVWYGQKLDFFKSAHLGSAAPNTEVMLVQERRQVRILDCMKGKRPLILNFGS
CSuPPFMTRLAAFQRVVRQYADIADFLVVYIEEAHPSDGWVSTDAPYQiPKHRCLEDRLRAAQLMLAEVPESNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRGPEGYRISELRSWLEQYRNDVARSQTAVLHV* 0
>DIO3a_tetNig Tetraodon nigroviridis (pufferfish)
0 MLLPRFLLTAVALWLLDFLCIRRKVLLQMGQRQKSADDPPVCVSDSNKMFTLESLRAVWYGQKLDFLKSAHLGSAAPNTEVMLVQERRQVRILDCMKGKRPLVLNFGS
CS-PPFMTRLAAFQRIVRQYADIADFLVVYIEEAHPSDGWVSTDAPHQIPKHRCLEDRLRAAQLMLAEVPESNVVVDNMDNSSNAAYGAYFERLYILRDERVVYQGGRGPEGYRISELRTWLEQYRNDVAESQTAVLHV * 0
>DIO3a_gasAcu Gasterosteus aculeatus (stickleback)
0 MHDSGGGVRTARALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKVLLKMGERQDSPDDPPLCVSDSNRMFTLESLRAVWYGQKLDCLKAAHLGRAAPNTEVMLVQQRRRVPILDCTKGKRPLILNFGS
CS-PPFMTRLAAFQRVVSQYADIADFLLVYIEEAHPSDGWVSSDAPYQIPKHRCLEDRLRAARLMLAEVPGSDVVVDNMDNSSSAAYGAYFERLYVVRDERVVYQGGRGPEGYRISELRAWLDEYRSELARSQTAVLHV* 0
>DIO3a_oryLap Oryzias latipes (medaka)
0 MDDSSGVQMARALKQAALCLMLLPRFLLAAVMLWLLDFLCIRRKLLLKMGERQDSPDDPPLCVSDSNKMFTLESLRAVWHGQKLDILKTAHLGQTAPNTEVVLVQERRQVRILDCMKGNRPLILNFGS
CSuPPFMMRLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPHQIPKHRCLEDRLRAAALMLTEVPGSKVVVDNMDNSSNAAYGAYFERLYVVRDETVVYQGGRGPEEYRISELKTWLQQYRKELLHSQNAVLHV* 0
>DIO3a_pimPro Pimephales promelas (fish)
0 MEMLHGSAGVQTAKALKNAAVCLMLLPRFLLAALTLWLLDFLCIRRKLLMKMRESDIASPDDPPMCVSDSNKMFTLESLRAVWYGQKLDFFKTARLGGAAPNTEVVPLDSTRLRGTRRILDYARGRRPLIVNFGS
CS-PPFMTRLSAFQRVARQYADIADSLLVYIEEAHPSDGWVSSDAPYQIPRHRCLEDRLRAAELMNQKVPECAIVVDTMENSSNSAYGAYFERLYILKDEKVVYQGGRGPEGYRISELRDWLERYRNELEAS* 0
>DIO3a_ictPun Ictalurus punctatus (fish)
0 MPDVQDFVKALKNALVSLMLLPRFLLTAVLLWFLDFVCIRRKVLVKMREREGSSPDDPSVTVSDSNRMFTVESLRAVWYSQKLDFCKTAHLGLTAPNSEVVPLGERKRARILDYARGSRPLILNFGS
CS*PPFMTRLAAFRRVADQYADIADSLLIYIEEAHPSDGWVSTDAPYQIPRHRCIKDRLRAARLMTATVPGSIVVVDTMDNSSNAAYGAYFERLYVVKDEKVVYQGGRGPEGYRIFEL NWLEPYRQKARGSRPIVGHV* 0
>DIO3a_spaAur Sparus aurata (fish)
0 MHDSGGVQMARALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKKVLLKMGERQDGPDDPPVCVSDSNKMFTLESLRAVWYGQKLDFLKSAHLGRTAPNTEVMLVQERRQVRILDCMKGKRPLILNFGS
CSuPPFMTRLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPYQIPKHRCLEDRLRAAQLMLAEVPGSNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRGPEGYRISELRNWLEQYRNGLVNSQTAVLHV* 0
>DIO3a_parOli Paralichthys olivaceus mRNA
MVHDSGGVQMARALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKKVLLKMGERQDGPDDPPVCVSDSNKMFTLESLRAVWYGQRLDFFKSAHLGRAAPNTEVVLVQEGRQVRILDCMKGKRPLILNFGS
CSuPPFMTRLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPFQIPKHRCLEDRLRAAQLMLSEVPGGNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRGPEGYQISGLRDWLEQYRSDLVNSKTPVLHV* 0
>DIO3b_takRub Takifugu rubripes (fugu) 1 exon N's
0 MNTIKSIKNALVFFVLLPRFLVAAVMFWLLDFLCIRKRVFFRMKEQEDDAVDPPLCISDSNRLFTVESLKAVWHGHKLDFLKAAHLGQGAPNTEVVQLEDQRRSRILDYAKDKRPLILNFGS
CTuPPFMARLKAFRGSWSKTQTSRLCSCVIEEAHPSDGWVSTDAPYQIPKHRCLADRLGAAQLMRLEVPGCLIVVDSMENSSNVAYGAYFDRLYILQEGKIVYQGGRGPEGYRITELRDWLVEYRESLKSSNDLVIHL* 0
>DIO3b_tetNig Tetraodon nigroviridis (pufferfish)
0 MNTMKSIKNALVFFVLLPRFLMAAVMFWLLDFLCIRKRVFFRMKEQEDDAVDPPLCISDSNRLFTVESLKAVWHGHKLDFLKAAHLGQGAPNTEVVQLEDQRRSRILDYAKDKRPLILNFGS
CTuPPFMARLKAFQGVVEQNADIADTVVVYIEEAHPSDGWVSTDAPYQIPKHRCLEDRLSAAQLMRLEVPGCLVVVDSMENSSNAAYGAYFDRLYILQEGKIVYQGGRGPEGYRITELRDWLEKYRKSLETSNNLVIHL* 0
>DIO3b_gasAcu Gasterosteus aculeatus (stickleback)
0 MNTIKAIKNAIVCLALLPRFLMAAFMFWLLDFLCIRRRVFFRMEQQEGDAIDPPLCMSDSNRLFSLESLKAVWHGHKLDFLKAAHLGHGAPNTEVVHLGDQRRGHILDYAKEKRPLVLNFGS
CTuPPFMARLKAFQGVVQQNADIADSVVVYIEEAHPSDGWMSTDAPYQIPKHRCLEDRLNAAQLMHLEVPGCPLVVDSMENSSNAAYGAYFDRLYILQEGTIVYQGGRGPEGYRVTELRDWLDRYRQTLGKSSQLVMSV** 0
>DIO3b_oryLap Oryzias latipes (medaka)
0 MNTMKALKNAIVCLLLLPRFLLAAVVFWLLDFSCIRKRVFLRMKEQGGDATDPPLCISDSNRLFSVESLKAVWHGHKLDFLKAAHLGRGAPNTEVVHLEDQRCSRILDYAKDKRPLILNFGS
CTuPPFMARLKAFQGVVQQNADIADSLVVYIEEAHPSDGWMSTDAPYQIPKHRRLEDRLNAAQLMHLEVPGCLVVVDSMENSSNAAYGAFFDRLYILQEGKVVYQGGRGPEGYRISELRDWLDQYRKGMEKSNNLVINM* 0
>DIO3_squAca Squalus acanthias (spiny dogfish)
0 MNLLKEAVAVLILLPRFLVTALMLWLLDILCIRKRLLSKSREQTEGNADDPPLCVSDTNRMFTLESLKAIWHGQKLDFFKSAHVGSPAPNPEVVQLQEQRKVRLLDYSRGARPLILNFGS
CTuPPFMARLKAFQRVAIQYADIADFLLVYIEEAHPSDGWVSTDAPYDIPRHRCLEDRLKAARLMHKENPSCLVVADTM
>DIO3_calMil Callorhinchus milii (elephantfish)
0 MKLLKEAMAVLVLLPRFIVTALTLWLLDILCIRKRLLCKLRARYEE AAELLGPGAGPPAPD HRMLTAEGMQVVWQSFLLDALKQVKVGLEAPNSAVARLDGGAPCRLLDFASRDRPLVVNFGS
ATuPPFVSRLPAFRQMVERYAEVADFLLVYVDEAHPSDGWALRSRFQLRRHRSQEERCSAAGLLAREFGLPAACGVVADLMDNNANRAYGVAFERLCVVQSQKIAYLGGKGPFFYNLNGVREWLERHSGQRWG* 0
>DIO3_braFlo Branchiostoma floridae (amphioxus) taa 1 exon closer match to DIO3
0 MGCGHHSSLSPHSVERPNAGMLCEAVRPLKALAAPILFVVLCFAFFLLKTASIVLTFVAPAKKEDLLAKLLGREEQEQTSSFQYDIDEFLTWNSLKGLVYSQMVGIMKRARHGKPAPDPTLVLLDSVTEKTLLSFAVADRPLFVNFGS
YTuPPFVPDLAVFDEIVAEFGERVDFLLVYIEEAHPTDGWSFRAGPDITSHQSIGQRCTAARAMLANRTVLYNVAVDSMTNSANYQYGAFPDRVYIIRHGQVVYEGGKGPFKYSLQEARTWLQENIGQQKN* 0
SELH: 25 vertebrate sequences
>SELH_homSap Homo sapiens (human) NP_734467 Selenoprotein H exons chr11 80% identity musMus 0 MAPRGRKRKAEAAVVAVAEKREKLANGGEGMEEATVVIEHC 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNPTKPRRGSFEVTLLRPDGS 1 2 SAELWTGIKKGPPRKLKFPEPQEVVEELKKYLS* 0 >SELH_ponPyg Pongo pygmaeus (orang_sumatran) 0 MAPRGRKCKAEATVVAVAEKrEKLTNGGEGMEEATIVIEHC 2 1 TSuRVYGRNAAALSQVLCLEAPELPVKVNPTKPRRGSFEVTLLRPDGS 1 2 SVELWTGIKKGPPCKLKFPEPQEVVEKLKKYLS* 0 >SELH_macMul Macaca mulatta (rhesus) 0 MAPRGRKRKAEAAMVAAAEKQEKLANSGEGMEETTVVIEHC 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNPSKPRRGSFEVTLLRPDGS 1 2 SAELWTGIKKGPPRKLKFPEPQEVVEELKKYLS* 0 >SELH_micMur Microcebus murinus (mouse_lemur) 0 MAPRGRKRKAEASVVATAEKREKLENGGEAVEEATVVIEHC 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNPAKPRRGSFEVTLQRPDGS 1 2 SAELWTGIKKGPPRKLKFPEPQVVVKELKKYL.* 0 >SELH_tupBel Tupaia belangeri (tree_shrew) 0 MAPRGRKRKAEAAVVATAEKQEKLQNGGEGVKEASIVIEHC 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNSAKPRRGSFEVTLLRPDGS 1 2 SVELWTGIKKGPPRKLKFPEPQEVVEELKKYLS* 0 >SELH_musMus Mus musculus (mouse) 0 MAPHGRKRKAGAAPMETVDKREKLAEGATVVIEHC 2 1 TSuRVYGRHAAALSQALQLEAPELPVQVNPSKPRRGSFEVTLLRSDNS 1 2 RVELWTGIKKGPPRKLKFPEPQEVVEELKKYLS* 0 >SELH_ratNor Rattus norvegicus (rat) TGA verified 77% 0 MAPLGRKRKAGAAPIESADKREKLAEGAAVVIEHC 2 1 TSuRVYRRHAAALSQALQLEAPEISVQVNRSKPRRGSFEVTLLRPDNS 1 2 RVELWTGIKKGPPRKLKFSEPQEMVEELKKYLS* 0 >SELH_speTri Spermophilus tridecemlineatus (squirrel) 0 MAPRVRKRKAEAAAVSTSEKREKLENGKEQVEEAVVIEHc 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNPSKPRRGSFEVTLLRRDGTS 1 >SELH_oryCun Oryctolagus cuniculus (rabbit) 0 MAPGKRKRKAEAAPVASAEKREKLANGGQGVEEIVIEHc 2 1 tSuRVYGRNAAALSQALRLQAPELPVTVNPSKPRRGSFEVTLLRPDGS 1 2 gAELWTGIKKGPPRKLKFPEPQQVVEELKKYLS* 0 >SELH_ochPri Ochotona princeps (pika) 0 MAPNRRKRKAEAVADAAAEKREKQAKQANGVGGGEEIVIEHc 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNPAKPRRGSFEVTLQRPDGS 1 2 SAELWTGIKKGPPRKLKFPEPQQVVEELKKYLS* 0 >SELH_canFam Canis familiaris (dog) 0 MASRGRKRKAEAAGVAAAEKRDKPASGRKAVEEATVVIEHC 2 1 TSuRVYGRNAAALSQALRLETPELPVEVNPAKPRRGSFEVTLLRPDGS 1 2 SVELWTGIKKGPPRKLKFPEPQEVVKALKQHLS* 0 >SELH_bosTau Bos taurus (cow) TGA verified 0 MASRGRKRKAEAALAAAAEKREKPAGGQEGGVEGPSVVIEHC 2 1 TSuRVYGRNAAALSQALRLQAPELTVKVNPARPRRGSFEVTLLRADGS 1 2 SAELWTGLKKGPPRKLKFPEPHVVLEELKKYLS* 0 >SELH_oviAri Ovis aries (sheep) 0 MASRGRKRKAEAALAAAAEKREKPAGSREGEVAGPSVVIEHC 2 1 TSuRVYGRNAAALSQALRLQAPELAVKVNPSRPRRGSFEVTLLRADGS 1 2 AELWTGLKKGPPRKLKFPEPHVVLEELKKYLS* 0 >SELH_susScr Sus scrofa (pig) 0 MASRGRKRKAETALGAAAEKQETPASGRKGMEEPSVVIEHC 2 1 TSuRVYGRNAAALSQALRVEAPELPVRVNPTKPRRGSFEVTLMRPDGS 1 2 SAELWTGIKKGPPRKLKFPEPQEVVEELKKYLS* 0 >SELH_equCab Equus caballus (horse) 0 MASRGRKRKAEAVVAVAEKREKLTSGGKGVEEVTVVIEHc 2 1 TSuRVYGRNAAALSQALRLEAPELPVKVNPAKPRRGSFEVTLLRPDGS 1 2 sAELWTGIKKGPPRKLKFPEPQEVVEELKKYLS* 0 >SELH_choHof Choloepus hoffmanni (sloth) 0 MASRGRKRKAEAVVLAAAEKQEKVASGKEGEKEAVVVIEHC 2 1 TSuRVYGRNAAALSQALRLEAPEIPVKVNFAKPRRGSFEVTLLRPDGS 1 2 TELWTGIKKGPPRKLKFLQPLKVVEELKKYLS* 0 >SELH_loxAfr Loxodonta africana (elephant) 0 MASRGRKRKAEAAVAAAAAEKREKPVGGQAAAEEVVVIIEHC 2 1 TSuRVYGRNAAALSQALRLEAPELSVKVNPSKPRRGSFEVTLQRPDGS 1 2 GAELWTGIKKGPPRKLKFPEPQEVVEELKKYL* 0 >SELH_monDom Monodelphis domestica (opossum) 0 MAPRGRKRKADVAAAALTEKPEKLAQGGEEGAGEARVVIEHC 2 1 QSuRVYARHAEAVGQALRLARPGLPVLLNPAKPRRSSFEVTLLRPDGS 1 2 RVELWSGIKKGPPRKLKFPEPAQVVEELKARLV* 0 >SELH_ornAna Ornithorhynchus anatinus (platypus) E5DI3CH10F50JR run=R_2008_02_11_18_03_02_ 0 DAGGAEVGEGLHVVIEHC 2 1 RSuGVYGRRAEALSRALSLAAPDLPVLLNPTKPRRNSFEVTLLRPDGT 1 2 RTELWSGIKKGRP >SELH_galGal Gallus gallus (chicken) tga confirmed 0 MAPRGRKRAARRPAEPEARADPPEKRPRDEAEGSPGDAGGPRVVIEHC 2 1 RSuRVYGRNAAALSEALRGAVASLAVEINPRQPRRNSFEVSLVKEDGS 1 2 TVQLWSGIGKGPPRKLKFPEPAAVVEALRSSLA* 0 >SELH_danRer Danio rerio (zebrafish) AI877878 BM037625 etc CKSU tga verified exons fused 0 MATRGKSARKRKADSDEKEKLDDAKKEKLEDKDEETGLRVVIEHC 2 1 KSuRVYGRNADVVREALADSHPELKVMINPHKPRRNSFEITLMDGERADVLWSGIKKGPPRKLKFPEPAEVVTALKQALEKE* 0 >SELH_takRub Takifugu rubripes (fugu) tga confirmed, no Ests 3 exons 0 MTPRVLMTGRRGTKRKAEEDEKPKEEKKEKQREDDQGGPRVAIEHC 2 1 KSuRVYGRNAEAVKSALLAAHPGLTVVLNPEKPRRNSFEITLLDEGK 1 2 ETSLWTGIKKGPPRKMKFPQPDVVVTALQEALKTE* 0 >SELH_ictPun Ictalurus punctatus (fish) CB940790 tga verified 0 MATRAKAGRGAKRKADVIAAAEPVAKQDKGNKGEREDDEGQRVIIEHC 2 1 KSuRVYGRNADAVREALLSAHPELHVVLNPEKPRRNSFEVTLIEGK 1 2 KELVLWTGLKKGPPRKLKFPEPAEVVTALEEALKSK* 0 >SELH_salSal Salmo salar CA043802 tga verified 0 MASRNKAGRVLKRKASVKEESVEEKRGKGEDDQPEIVTEGRRVVIEHC 2 1 KSuRVYGRNAEGVRVALLAACPDLTVVLNPQKPRSKSFEVILVEGE 1 2 KEVCLWSGIKKGPPRKLKFPEPEVVVSALEKALKTE* 0 >SELH_oryLat Oryzias latipes BJ026077 tga verified 0 MASKAGRRGTKRKVEAKKEEDKTSTEEKKARGENAHEEAGLKVLIEHC 2 1 KSuRVYGRNAEEVKSALLAARPELTVVCNPEKPRRNSFEITLLDGAK 1 2 ETSLWTGIKKGPPRKLKFPQPDDVVAAFKDALKTE* 0 >SELH_oncMyk Oncorhynchus mykiss Rainbow trout BX312781 0 MASLTKAGRVLKRKVETEESSVEGKRGKGEDDHPEIVTEGQRVVIEHC 2 1 KSuRVYGRNAEGVRVALLAACPDLTVVLNPQKPRSKSFEVILFEGE 1 2 KEVCLWSGIKKGPPRKLKFPEPEVVVSALEKALKTE* 0
SELM: 22 vertebrate sequences
>SELM_homSap Homo sapiens (human) NM_080430 Selenoprotein M (uc003ajq.1) chr22 0 MSLLLPPLALLLLLAALVAPATAATAYRPDWNRLSGLTRARVE 0 0 TCGGUQLNRLKE 0 0 VKAFVTQDIPFY 2 1 HNLVMKHLPGADPELVLLGRRYEELE 0 0 RIPLSEMTREEINALVQELGFYRKAAPDAQVPPEYVWAPAKPPEETSDHADL* 0 >SELM_musMus Mus musculus (mouse) 0 MSILLSPPSLLLLLAALVAPATSTTNYRPDWNRLRGLARGRVE 0 0 TCGGUQLNRLKE 0 0 VKAFVTEDIQLY 2 1 HNLVMKHLPGADPELVLLSRNYQELE 0 0 RIPLSQMTRDEINALVQELGFYRKSAPEAQVPPEYLWAPAKPPEEASEHDDL* 0 >SELM_ratNor Rattus norvegicus (rat) 0 MNILLSPPPLLLLLAALVAPATSITTYRPDWNRLRGLARGRVE 0 0 TCGGUQLNRLKE 0 0 VKAFVTQDIQLY 2 1 HNLVMKHLPGADPELVLLSRNYQELE 0 0 RIPLSQMTRDEINALVQELGFYRKSAPEAKVPPEYLWAPAKPPEDASDRADL* 0 >SELM_canFam Canis familiaris (dog) 0 MRLPLPPPPLLLLLAALAAAVTTFRPDWNRLHGLARARVE 0 0 TCGGUQLNRLKE 0 0 VKAFVTQDIPLY 2 1 HNLVMKHLPGADPELVLLGHHYEELE 0 0 RIPLSEMTREEINELVQELGFYRKAAPDEAVPPEYLRAPARPAEGAPDRADL* 0 >SELM_bosTau Bos taurus (cow) 0 MHLPLPPPPLLLLLAAVAAATTTFRPDWNRLQGLARARVE 0 0 TCGGUQLNRLKE 0 0 VKAFVTQDIPLY 2 1 HNLVMKHLPGADPELVLLGHRFEELE 0 0 RIPLSDMTREEINALVQELGFYRKASPDEPVPPEYLRAPARPAGDAPDHADL* 0 >SELM_susScr Sus scrofa (pig) 0 MHLPPLSLPLLLLLAALAAATTTFRPDWNRLQGLARARVE 0 0 TCGGUQLNRLKE 0 0 VKAFVTQDIPLY 2 1 HNLVMKHLPGADPELVLLGHRFEELE 0 0 RIPLSDMTREEINALVQELGFYRKAAPDDPVPPEYMRAPARPAEGAPDRADL* 0 >SELM_ornAna Ornithorhynchus anatinus (platypus) 0 MLVCPERRSWVLIPPLSLLLLLPGLLAAFQPDWSRLQGLARGKVE 0 0 TCGGuQLNRLKE 0 0 VKAFVTEDIPLY 2 1 HNLVMKHLPGADPELVLLNFRYEELE 0 0 RIPLSHMTRAEINQLVQDLGFYRKAERDAPVPPEFQQAPAKTSDLREKVQPQETPKSEEQNHPDL* 0 >SELM_galGal Gallus gallus (chicken) 0 MRRAALAALLLLLAAAAGIERRPPRGLARGKVE 0 0 TCGGURLSRLPE 0 0 VKAFVSQDIPLY 2 1 HNLEMKHLPGADPELVLLSFRYEELE 0 0 RIPLSDMTREEINQLVQELGFYRKETPEAPVPEEFQFAPAKPLPTLTPRRAPAADGKTLSEQDKKDHPDL* 0 >SELM_botIns Bothrops insularis (snake) PVPDAFQMA ..PLLWLPLLLLGLLSAVAPLRAVQLDRSRLQWLARGKVE 0 0 SCGGURLNRLPE 0 0 VKAFLNEDLPLY 2 1 HNMDLKYLAGADPELILLNIKFEELQ 0 0 RIPLSDMSREEINQLMQELGFYRKDTPDSLFRCFPNGAC* 0 >SELM_xenTro Xenopus laevis (frog) 0 MWLPLPLLLGLLQLQPILSYQIDWNKLERINRGKVE 0 0 SCGGUQLNRLKE 0 0 VKGFVTEDLPLY 2 1 HNLEMKHIPGADPELVLITSRYEELE 0 0 RIPLSDMKRDEINQLLKDLGFYRKSSPDAPVPAEFKMAPARASGDTKEDL* 0 >SELM_danRer Danio rerio (zebrafish) 0 MWPLIFTALLPSVILTYEVNIEKLSGLARARVE 0 0 TCGGUQLNRMRE 0 0 VKAFVTQDIPLY 2 1 HNLVMKHIPGADPELVLLNHYYEELD 0 0 RIPLSEMTRAEINKLLAELGFYKKDHPEDQVPEEFRFSPAKDSPFEGRQSSTAAPETTEPSDSQHTDL* 0 >SELM_ictPun Ictalurus punctatus (fish) 0 MFSTWPLLWAAFLPCISLAYEVDWKKLDGLARAKVE 0 0 SCGGUQLNRLRE 0 0 VKAFVTQDIPFY 2 1 HNLVMKHIPGADPELVLLNHYYEELD 0 0 RIPLSHMTRTDINGLLEELGFYKKARAEDDVPEEFRFSPAKDSPFKEHHTRRAPANSDLAQEPQPENESPHKDL* 0 >SELM_oncMyk Oncorhynchus mykiss (trout) 0 MWFFFFVSLLNCVSAYDVDLKKLDGLAKAKVE 0 0 SQSCGGUQLNRLRE 0 0 VKAFVTQDIPLY 2 1 HNLVMKHIPGADPELVLLNHYYEELD 0 0 RIALSDMTRSEINELLEKLGFYKKAQAEDQVPEEFRFSPAKDSPFKATPADNASSDSDAEAKHSDL* 0
MSRB1: 17 vertebrate sequences
>MSRB1_homSap Homo sapiens (human) SEPX1 (uc002cng.1) SELX SELR human chr16 0 MSFCSFFGGEVFQNHFEP 1 2 GVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRSEALK 0 0 VSCGKCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFVPK 1 2 GKETSASQGH* 0 >MSRB1_macMul Macaca mulatta (rhesus) 0 MSFCSFFGGEVFQNHFEP 1 2 GVYACAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRPGALK 0 0 VSCGKCGNGLGHEFLNDGPKPGQSRFuIFSSSLKFVPK 1 2 GKETSTSQGH* 0 >MSRB1_musMus Mus musculus (mouse) exon break just at stop codon NP_038787 0 MSFCSFFGGEVFQNHFEP 1 2 GVYVCAKCSYELFSSHSKYAHSSPWPAFTETIHPDSVTKCPEKNRPEALK 0 0 VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFVPK 1 2 GKEAAASQGH* 0 >MSRB1_ratNor Rattus norvegicus (rat) 0 MSFCSFFGGEVFQNHFEP 1 2 GVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHEDSVAKCPEKNRPEALK 0 0 VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK 1 2 GKEAPASQGD* 0 >MSRB1_cavPor Cavia porcellus (guinea_pig) 0 MSFCSFFGGEVFQNHFES 1 2 GIYVCAKCGYELFSSRSKYAHSSPWPAFTDTIHADSVAKCPEHNRPGALK 0 0 VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK 1 2 DKETSASQGH* 0 >MSRB1_canFam Canis familiaris (dog) frag 0 MSFCSFFGGEVFQNHFEP 1 2 GVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPERNSPEALK 0 0 VSCGKCGNGLGHEFLNDGPKPGKSRFuIFSSSLKFVPK 1 2 GKGTSGSQEA* 0 >MSRB1_bosTau Bos taurus (cow) 0 MSFCSFFGGEIFQNHFEP 1 2 GIYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRPGAIK 0 0 VSCGRCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK 1 2 AEETSASQGQ* 0 >MSRB1_equCab Equus caballus (horse) 0 MSFCSFFGGEIFQNHFEP 1 2 GIYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRPEALK 0 0 VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFVPK 1 2 GKESSASQGQ* 0 >MSRB1_ loxAfr Loxodonta africana (elephant) 0 MSFCSFFRSEVFQNHFEP 1 2 GVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVGKHPEHNRPEALK 0 0 VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK 1 2 GKETSASQGK* 0 >MSRB1_monDom Monodelphis domestica (opossum) frag 2 GVYVCAKCGYELFSSRSKYHHSSPWPAFTETIHADSVSKRPESGRSEALK 0 0 VSCGKCGNGLGHEFINDGPKKGQSRFuIFSSSLKFVPKG 1 >MSRB1_ornAna Ornithorhynchus anatinus (platypus) 0 1 2 GTYVCARCGYELFSSRSKYEHSSPWPAFTETIHPDSVAKREEPGRPNAFK 0 0 VSCGKCGNGLGHEFLNDGPRRGQSRFuIFSSLKFIPK 1 2 GKDSQAAQDK* 0 >MSRB1_galGal Gallus gallus (chicken) 0 MSFCSFFGGEVFKDHFEP 1 2 GVYVCARCGYELFSSRAKYEHSSPWPAFTETIHEDSVAKRKERPGALK 0 0 VSCGKCGNGLGHEFLNDGPKRGQSRFuIFSSSLKFIPK 1 0 GKSPQEN* 0 >MSRB1_anoCar Anolis carolinensis (lizard) 0 MSFCAFSGGEIYQGHFEA 1 2 GMYVCSKCGFELFSSKSKYAHSSPWPAFTETIHDDSITKYLERPNAFK 0 0 VLCGKCGNGLGHEFINDGPKKGQSRFZIFSSSLKFVPK 1 >MSRB1_xenTro Xenopus tropicalis (frog) 0 MSFCSFFGGEVYKDHFKS 1 2 GIYVCSECNYELFSSRSKYQHSSPWPAFTETVHKDSISKYLERPNAYK 0 0 VSCGKCGNGLGHEFINDGPKKGQSRFuIFSSSLKFIPK 0 0 DKVDGEVQRE* 0 >MSRB1_danRer Danio rerio (zebrafish) tga confirmed 0 MSFCSFSGGEIYKDHFES 1 2 GMYVCAQCGYELFSSRSKYEHSSPWPAFTETIHEDSVSKQEERWGAYK 0 0 VRCGKCGNGLGHEFVNDGPKHGLSRFuIFSSSLKFI 0 PKVKNEQQ* 0 >MSRB1_ictFur Ictalurus furcatus (fish) 0 MAFCSFKGGEIFKDHYEP 1 2 GIYVCVKCGYELFSSTSKYKLSSPWPAFTTTIHEDSVSKQEERPGALK 0 0 IRCGKCNNGLGHEFLNDGPKHGLSRFuIFSSSLKFV 0 0 PKDKGGQ* 0 >MSRB1_oncMyk Oncorhynchus mykiss (trout) 0 MSFCSFFGGEVFKDHFKT 1 2 GLYMCAQCGHQLFSSRSKYEHSSPWPAFTETILQDSVSKHEERPGAFK 0 0 VRCGKCGNGLGHEFVGDGPKKGLSRFuIFSSSLKFV 0 0 PKDKVDGQ* 0 >MSRB1_salSal Salmo salar (salmon) 0 MSFCSFFGGEVFKDHFKT 1 2 GLYVCAQCGHQLFSSRSKYEHSSPWPAFTETVLQDSVSKHEERPGAFK 0 0 VRCGKCGNGLGHEFVGDGPKKGLSRFuIFSSSLKFV 0 0 PKDKVDGQ* 0 >MSRB2_homSap Homo sapiens (human) CBS-1 PILB 5 exons chr10 0 MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEA 1 2 GSLATCELPLAKSEWQKKLTPEQFYVTREKGTEP 0 0 PFSGIYLNNKEAGMYHCVCCDSPLFS 2 1 SEKKYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQ 0 0 CEAHLGHVFPDGPGPNGQRFCINSVALKFKPRKH* 0 >MSRB2_musMus Mus musculus (mouse) 0 MARLLRALRGLPLLQAPGRLARGCAGS 1 2 GSKDTGSLTKSKRSLSEADWQKKLTPEQFYVTREKGTEA 0 0 PFSGMYLNNKETGMYHCVCCDSPLFSSEKKYCSGTGWPSF 2 1 SEAYGSKGSDESHTGILRRLDTSLGCPRMEVVCKQ 0 0 CEAHLGHVFPDGPKPTGQRFCINSVALKFKPSKP* 0 >MSRB2_bosTau Bos taurus (cow) 0 MARLLRALRGLTLREAPGWAVRGRADCGGFRAGA 1 2 GSPQAAHPDTFPFHRGSKSEWQKKLTPEQFHVTREKGTEP 0 0 PFSGIYLNNKEPGMYHCVCCDSPLFS 2 1 SEKKFCSGTGWPSFSEAHGTSGSDESNTGILRRADTSLGPARTEVVCKQ 0 0 CEAHLGHVFPDGPGPAGQRFCINSVALRFKPRKH* 0 >MSRB2_canFam Canis familiaris (dog) 0 MGDSSTTLRFLIRKRHSPYDFVVKIDKSKPKEERSLTKHEL 0 0 PLTKSEWQKKLTPEQFYVTREKGTEP 0 0 PFSGVYLNNKESGMYHCVCCDSPLFS 2 1 SEKKYCSGTGWPAFSEAHGTSGSDERDTGILRRVDTSLGLTRTEVVCKQ 0 0 CEAHLGHVFPDGPGPSGQRFCINSVALKFKPRKH* 0 >MSRB2_xenTro Xenopus laevis (frog) 0 MSRLLTGFRLLLRVREISFPSVTAQRLQAWSRVRMAQTGADL 1 2 GSLTRYDDSAVSTDWQKKLTPEQYYVTREKGTEL 0 0 PFSGIYLNNTEKGMYHCVCCSAPLFS 2 1 SEKKYNSGTGWPSFSEAYGAQGADESNTNVLRRLDNSLGSTGTEVICKE 0 0 CDAHLGHVFEDGPPPYGQRFCINSVALTFAPSSM* 0 >MSRB3_homSap Homo sapiens (human) ER retention signal KAEL* AY358229 0 MSPRRTLPRPLSLCLSLCLCLCLAAALGSAQS 1 2 GSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTES 2 1 AFEGEYTHHKDPGIYKCVVCGTPLFK 2 1 SETKFDSGS 1 2 GWPSFHDVINSEAITFTDDFSYGMHRVETSCSQ 0 0 CGAHLGHIFDDGPRPTGKRYCINSAALSFTPADSSGTAEGGSGVASPAQADKAEL* 0 >MSRB3_musMus Mus musculus (mouse) 0 MSAFNLLHLVTKSQPVAPRACGLPSGSCRDKK 1 2 NCKVVFSQQELRKRLTPLQYHVTQEKGTES 2 1 AFEGEYTHHKDPGIYKCVVCGTPLFK 1 1 SETKFDSGS 1 2 GWPAFHDVISSEAIEFTDDFSYGMHRVETSCSQ 0 0 CGAHLGHIFDDGPRPTGKRYCINSASLSFTPADSSEAEGSGIKESGSPAAADRAEL* >MSRB3_canFam Canis familiaris (dog) 0 MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCK 1 2 VVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFRSESKFDSGS 1 2 GWPSFHDVISSDAITFTDDFSYGMHRVETSCSQ 0 0 CGAHLGHIFDDGPRPTGKRYCINSASLAFTPAGGGTQGSSGPGGPAAGGRAEL*
SELO: 5 vertebrate sequences
The terminal exon containing the selenocysteine is evolving very erratically in length, suggesting that is unimportant. VRRVLKLLETPYHCEAGAATDAEATEADGADGRQR SYSSKPPLWAAELCVTuSS* SELO_homSap Homo sapiens (human) VRRVLKLLETPYHCESGAATDAEATEANGADGRQR SYSSKPPLWAAELCVTuSS* SELO_panTro Pan troglodytes (chimp) VRRVLKLLETPYHCEAGAATDAEATEADGADGRQR SYSSKPPLWAAELCVTuSS* SELO_ponPyg Pongo pygmaeus (orang_sumatran) VRRVLKLLETPYHCEAGAATDAEATEADGADGRQR SYSSKPPLWAAELCVTuSS* SELO_macMul Macaca mulatta (rhesus) VQRVLKLLETPYDNGGGAAAEPKDGSRAASRRP SYSSKPPLWAAELCVTuSS* SELO_otoGar Otolemur garnettii (bushbaby) VRRVLKLLESPYHSEEEATGPEAVARSTEEQS SYSNRPPLWAAELCVTuSS* SELO_musMus Mus musculus (mouse) VRRVLKLLESPYHSEEEATGPEAVARTTDEQS SYSSRPPLWAAELCVTuSS* SELO_ratNor Rattus norvegicus (rat) VRRVLKLLESPYQHEGEHAEALEVAGPEGAATGASRRP SYSSKPPLWAAELCVTuSS* SELO_cavPor Cavia porcellus (guinea_pig) VRRVLELLETPYHRAEEAARVPEATEPEGASGADSGGH SYSSKPPLWAAELCVTuSS* SELO_canFam Canis familiaris (dog) VRRVLKLLETPYGGEAEAEAAEPAEASEAAEETGGAAGRRR SYSSKPPLWAAELCVTuSS* SELO_bosTau Bos taurus (cow) VRRVLKLLETPYHREGEAAEPAEPEAAEGRL SYSSKPPLWAAELCVTuSS* SELO_susScr Sus scrofa (pig) VRRVLKLLEAPYHRAEEAAEVSEAAEPEGAGGASGRRR SYSSKPPLWAAELCVTuSS* SELO_equCab Equus caballus (horse) VRRVLKLLEAPYHREGEAAEVLEAAEPEGAGSTAERRR SYSSKPPLWAAELCVTuSS* SELO_myoLuc Myotis lucifugus (microbat)) VRRVLKLLETPYPQEREAPEALEAAEPQGAGRQD SYSSRPPLWAAELCVTuSS* SELO_eriEur Erinaceus europaeus (hedgehog) VRRVLKLLEAPYSREEPTEALELGEAAGAVGLQR SYSSRPPPWAAELCVTuSS* SELO_loxAfr Loxodonta africana (elephant) VQRVLRLLEKPYGEPWEDDADGLLAAAAAADSGEAESRR SYGRKPPLWAAELCVTuSS* SELO_monDom Monodelphis domestica (opossum) VRKVAKLLEHPYREEEGPDDGEGTADRSVRGL AYGGKPPHWAAQLCVTuSS* SELO_ornAna Ornithorhynchus anatinus (platypus) VRNVLKLLENPFQETEDSTEMETKEEEATATAAACAQATRSRL SYCSKPPLWASELCVTuSS* SELO_galGal Gallus gallus (chicken) VKRVLQMLENPYQEGESCQSIADKSPEEDVAVAASSVSTNPSRL PYNSKPPLWATELCVTuSS* SELO_xenTro Xenopus tropicalis (frog) VQRVLKVLEKPFSVQEGLEQPGWMGRGGAAIPGERDETEEEGSNSSGAGARGLVPYDSKPPVWANEICVTuSS* SELO_danRer Danio rerio (zebrafish) VQEERLRVMEGTNPEFPAWVGGSGEAANQGERDEGEEQQQAMASSSTPRNP VSYDSKPPAWAGEICVTuSS* SELO_takRub Takifugu rubripes (fugu) VHLLQKTLRHPFHKQREAEEA GYSSRPPLWARELRVSCSS* SELO_calMil Callorhinchus milii (elephantfish)
>SELO_homSap Homo sapiens (human) tga-sel taa-stop 0 MAVYRAALGASLAAARLLPLGRCSPSPAPRSTLSGAAMEPAPRWLAGLRFDNRALRALPVEAPPPGPEGAPSAPRPVPGACFTRVQPTPLR QPRLVALSEPALALLGLGAPPAREAEAEAALFFSGNALLPGAEPAAHCYCGHQFGQFAGQLGDGAAMYLGEVCTATGERWELQLKGAGPTPFSR 2 1 QADGRKVLRSSIREFLCSEAMFHLGVPTTRAGACVTSESTVVRDVFYDGNPKYEQCTVVLRVASTFIR 2 1 FGSFEIFKSADEHTGRAGPSVGRNDIRVQLLDYVISSFYPEIQAAHASDSVQRNAAFFRE 0 0 VTRRTARMVAEWQCVGFCHGVLNTDNMSILGLTIDYGPFGFLDR 2 1 YDPDHVCNASDNTGRYAYSKQPEVCRWNLRKLAEALQPELPLELGEAILAEEFDAEFQRHYLQKMRRKLGLVQVELEEDGALVSKLLETMHLT 1 2 GADFTNTFYLLSSFPVELESPGLAEFLARLMEQCASLEELRLAFRPQMDPR 2 1 QLSMMLMLAQSNPQLFALMGTRAGIARELERVEQQSRLEQLSAAELQSRNQGHWADWLQAYR 2 1 ARLDKDLEGAGDAAAWQAEHVRVMHANNPKYVLRNYIAQNAIEAAERGDFSE 0 0 VRRVLKLLETPYHCEAGAATDAEATEADGADGRQRSYSSKPPLWAAELCVTuSS* 0 >SELO_musMus Mus musculus (mouse) 0 MAVYRAALGASLAAARLLPLGRCSPSPAPRSTLSGAAMEPAPRWLAGLRFDNRALRALPVEAPPPGPEGAPSAPRPVPGACFTRVQPTPLR QPRLVALSEPALALLGLGAPPAREAEAEAALFFSGNALLPGAEPAAHCYCGHQFGQFAGQLGDGAAMYLGEVCTATGERWELQLKGAGPTPFSR 2 1 QADGRKVLRSSIREFLCSEAMFHLGVPTTRAGACVTSESTVVRDVFYDGNPKYEQCTVVLRVASTFIR 2 1 FGSFEIFKSADEHTGRAGPSVGRNDIRVQLLDYVISSFYPEIQAAHASDSVQRNAAFFRE 0 0 VTRRTARMVAEWQCVGFCHGVLNTDNMSILGLTIDYGPFGFLDR 2 1 YDPDHVCNASDNTGRYAYSKQPEVCRWNLRKLAEALQPELPLELGEAILAEEFDAEFQRHYLQKMRRKLGLVQVELEEDGALVSKLLETMHLT 1 2 GADFTNTFYLLSSFPVELESPGLAEFLARLMEQCASLEELRLAFRPQMDPR 2 1 QLSMMLMLAQSNPQLFALMGTRAGIARELERVEQQSRLEQLSAAELQSRNQGHWADWLQAYR 2 1 ARLDKDLEGAGDAAAWQAEHVRVMHANNPKYVLRNYIAQNAIEAAERGDFSE 0 0 VRRVLKLLETPYHCEAGAATDAEATEADGADGRQRSYSSKPPLWAAELCVTuSS* 0 >SELO_ratNor Rattus norvegicus (rat) 0 MASFRAAFGASLAVARTRPQCVGLELQSSAPWSAWAAAMEPTPRWLARLRFDNRALRALPVETPPPGPEDSLSTPRPVPGACFSRARPAPLR QPRLVALSEPALALLGLEVSEEAEVEAEAALFFSGNALLPGTEPAAHCYCGHQFGQFAGQLGDGAAMYLGEVCTAAGERWELQLKGAGPTAFSR 2 1 QADGRKVLRSSIREFLCSEAMFHLGIPTTRAGACVTSESTVMRDVFYDGNPKYEKCTVVLRIAPTFIR 2 1 FGSFEIFKPPDELTGRAGPSVGRNDIRVQMLDYVISSFYPEIQAAHTCDTDNIQRNAAFFRE 0 0 VTRRTARMVAEWQCVGFCHGVLNTDNMSIVGLTIDYGPFGFLDR 2 1 YDPDHVCNASDNAGRYTYSKQPQVCRWNLQKLAEALEPELPLVLAEAILKEEFDTEFQRHYLQKMRKKLGLVRVEKEDETLVAKLLETMHQT 1 2 GADFTNTFCVLSSFPAEPSDTAEFLTQLTSQCASLEELKLAFRPQMDPR 2 1 QLSMMLMLAQSNPQLFALIGTQANVTKELERVEHQSRLEQLSPSELQSKNRDHWETWLQEYR 2 1 ERLDKEKEGVGDIAAWQAERVRIMHANNPKYVLRNYIAQKAIEAAENGDFSE 0 0 VRRVLKLLESPYHSEEEATGPEAVARTTDEQSSYSSRPPLWAAELCVTuSS* 0 >SELO_galGal Gallus gallus (chicken) 0 MQRSGGVLRRGRADTERGETGGGWLSALRFDNLAMRSLPVDPFEDCAPRAVPGACFARVRPTPLRNPRLVAMSAPALALLGLEAGGPEAERE AEAALYFSGNRLLPGSEPAAHCYCGHQFGSFAGQLGDGAAIYLGEVRGPRGARWELQLKGAGITPFSR 2 1 QADGRKVLRSSIREFLCSEAMFHLGIPTTRAGTCVTSDSEVVRDIFYDGNPKKERCTVVLRIASTFIR 2 1 FGSFEIFKPPDEYTGRKGPSVNRNDIRIQMLDYVIGTFYPEIQEAHADNSIQRNAAFFKE 0 0 ITKRTARLVAEWQCVGFCHGVLNTDNMSIVGLTIDYGPFGFMDR 2 1 YDPEHICNGSDNTGRYAYNRQPEICKWNLGKLAEALVPELPLEISELILEEEYDAEFEKHYLQKMRKKLGLIQLELEEDSKLVSELLETMHLT 1 2 GGDFTNIFYLLSSFSVDTDPSRLEDFLEKLISQCASVEELRVAFKPQMDPR 2 1 QLSMMLMLAQSNPQLFALIGTKANINKELERIEQFSKLQQLTAADLLSRNKRHWTEWLEKYR 2 1 VRLHKEVESISDVDAWNTERVKVMNSNNPRYILRNYIAQNAIEAAENGDFSE 0 0 VRNVLKLLENPFQETEDSTEMETKEEEATATAAACAQATRSRLSYCSKPPLWASELCVTuSS* 0 >SELO_calMil Callorhinchus milii (elephantfish) frag tgt-cys not sel tag-stop? tga-stop? taa-stop 0 LNFDNLALRSLPVDSSGERSCRRVPGACFSLAGATPVDNPRLVASSR 0 0 QSDGRKVLRSSIREFLCSEAMFHLGIPTTRAGTCVTSDTKVLRDVFYDGNSKHENCTIILRIAPTFLRF 2 1 FGSFEILKPEDELTGRQGPSSNRNDIRIQMLDYVIGTFYPEAQQAHPENQVQRNAAFFRE 0 0 VTQRTARLVAEWQCVGFCHGVLNTDNMSIMGLTIDYGPFGFMDR 2 1 FDPSYICNASDNRGRYAYNQQPEICKWNLGKLAEVLVPELPLKDSQSIIDEEYDTEFQRHYLQKMRKKLGLLQCEQEDDDKLVSELLDIMYRT 1 2 GADFTNTFYLLSSFPVELESPGLAEFLARLMEQCASLEELRLAFRPQMDPR 2 1 QLSILLMLSQSNPQLFEVIGSKEGIAKELDLIERSSKLQQATAEDIHSNNAKVWTEWLQKYR 2 1 SRLATEAEGVDDVDEQNAERVKVMNLNNPKFILRNYIAQNAIEAAEKGDFSE 0 0 VHLLQKTLRHPFHKQREAEEAGYSSRPPLWARELRVSCSS-R-P* 0 >SELO_petMar Petromyzon marinus (lamprey) frag 0 GASMCSLYVLPLGRN 1 2 APRQVPGAVFSRVRPSPVERPRVVAISVPALRLLGLRDPEAEAARPEAAEFLSGNRVPPGAQPAAHCYCGHQFGSFAGQLGDGAAMYLGEVQPGPGQRWEVQLKGAGPTPYS 2 1 HSDGRKVLRSSLREFLCSEAMHHLGVPTTRAGSCVTSHSTVLRDVHYDGNARPEQCSVVLRIAPSFLR 0 1 FGSFEIFKSTDKDTGRTGPSAGREDIKVTMLDYVIDTFYPELLEGHGDGASHKYTAFFRE 0 0 VVRRTAHLVAEWQCVGFCHGVLNTDNMSILGLTIDYGPFGFMDR 2 1 GADFTNSFRLLSRLTLEPGSVEELATLLCQQCATVEEMKRAYKPRIDPR 2
SEPN1: 2 vertebrate sequences
>SEPN1_homSap Homo sapiens (human) 0 MGRARPGQRGPPSPGPAAQPPAPPRRRARSLALLGALLAAAAAAAVRVCARHAEAQAAARQ 0 0 ELALKTLGTDGLFLFSSLDTDGDMYISPEEFKPIAEKLT 1 2 GSTPAASCEEEELPPDPSEETLTIEARFQPLLPETMTKSKDGFLG 0 0 VSRLALSGLRNWTAAASPSAVFATRHFQPFLPPPGQELGEPWWIIPSELSMFTGYLSNNRFYPPPPKGKE 0 0 VIIHRLLSMFHPRPFVKTRFAPQGAVACLTAISDFYYTVMFR 2 1 IHAEFQLSEPPDFPFWFSPAQFTGHIILSKDATHVRDFRLFVPNHR 2 1 SLNVDMEWLYGASESSNMEVDIGYIPQ 0 0 MELEATGPSVPSVILDEDGSMIDSHLPSGEPLQFVFEEIKWQQELSWEEAARRLEVAMYPFKK 0 0 VSYLPFTEAFDRAKAENKLVHSILLWGALDDQSCu 1 2 GSGRTLRETVLESSPILTLLNESFISTWSLVKELEELQ 0 0 NNQENSSHQKLAGLHLEKYSFPVEMMICLPNGTV 0 0 VHHINANYFLDITSVKPEEIESNLFSFSSTFEDPSTATYMQFLKEGLRRGLPLLQP* 0 >SEPN1_petMar Petromyzon marinus (lamprey) tga-sel taa-stop frag 0 0 0 EMALRTLGNDGLFLFTSLDTNMDMQISPEEFRPIVDKII 1 2 GPPPSEYEGTQEADPQGEGLTMLARFEPLLMETMSKSRDGFLG 0 0 VGQSCLAGLRGWKKAEAPSQHFGANQFKVFLPPKSDLELGEAWWLVPNDLNLFTGYLPNSRYYPPPPVAKE 0 0 IIIFKLLSMFHPRPFVKSRFAPQGSVACIRAQSDMYYDIVFR 2 1 VHAEFQLNEPPAFPFWFTPAQFTGHVTIARDSSHVRAFHMFVPNNR 2 1 SLNVDMEWLFGSMDQGNMEVDIGFMPK 0 0 MELVAEGPSVPALIYDENGNAINTSDPDVEPIQFVFENIEWRSEISFQEAYRQMEVAMYPFKK 0 0 IQYHPFTEAFEKAKAEDKLVHSILLWGALDDQSCu 1 2 KVLTQSLKFDFNITSPVLALLSENFISSWSLVKDLEDL 0 0 KQEEQAEHAKWATLHLAKYTFPVEMMIALPNGTV 0 0 VHCINANDFLDATAVKAEDLTPDLPAEFLDPTSTTYLKFLKEGLQKAQTYLQA* 0
SEPHS1: 13 chordate sequences
>SEPHS1_homSap Homo sapiens (human) PHYH- SEPHS1- DUF1172- PRFF18+ FRMD4A- 0 MSTRESFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRL 1 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDR 0 0 ERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPGATS* 0 >SEPHS1_musMus Mus musculus (mouse) 0 MSTRESFNPETYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRL 1 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDR 0 0 ERDKVIPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPGATS* 0 >SEPHS1_loxAfr Loxodonta africana (elephant) frag 0 MSVRESFNPESYELDKSFRLTKFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRLGM 1 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGISNKMTDR 0 0 ERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTP 1 >SEPHS1_monDom Monodelphis domestica (opossum) 0 MSVRESFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRL 1 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGISNKMTDR 0 0 ERDKVVPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPEMAATALYTLDNNVLTLEQRQFYEDNGFLVIGATS* 0 >SEPHS1_ornAna Ornithorhynchus anatinus (platypus) virtual selenocys 0 MSVRESFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLEALQENHFQEDEQFLGAVMPRL 1 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGISNKMTDR 0 0 ERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPGATS* 0 >SEPHS1_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01BJUY7 454 0 AEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQ 0 2 AKQQRSEVSFVIHNLPIIAKMAAITKACGNRFGLLQGTSSETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPRIIEVTPRGAAAPPPDNNSSA >SEPHS1_galGal Gallus gallus (chicken) 0 MSvREtFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRL 1 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDR 0 0 ERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPGATS* 0 >SEPHS1_xenTro Xenopus tropicalis (frog) frag 0 MSVRESFNPESYELDKSFRLTRFAELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRL 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGVSNKLTDR 0 0 ERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWVVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGSCPETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVASQNVNPTPGATS* 0 >SEPHS1_danRer Danio rerio (zebrafish) first occurence of threonine form 0 MSVRESFNPESYELDKNFRLTRFTELKGTGCKVPQDVLQKLLESLQENHYQEDEQFLGAVMPRL 2 GIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGVSNKLTEK 0 0 ERGKVMPLVIQGFKDASEEAGTSVTGGQTVINPWIVLGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMLNMARLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLARQQRTEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETS 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNTTPGATS* 0 >SEPHS1_calMil Callorhinchus milii (elephantfish) frag 0 MSVRETFNPENYELDKNFRLTRFAELKGTGCKVPQDVLHKLLEALQENHYQEDEQFLGAVMPRL 1 2 GIGMDSCVIPLRHGGLSLVQTTDFFYPLVDDPYMM 0 0 GRIACANVLSDLYAMGVTECDNMLMLLGVSNKMADK 0 0 ERDKVMPLIIQGFKDAADEAGTAVTGGQTVLNPWIILGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMFNMARLNRT 1 2 1 2 GGLLICLPREQAARFCAEIKSPKYGEGYQAWIIGIVEKGNRTARIIDKPRIIEVAPTVATQNVNPTPGATS* >SEPHS1_petMar Petromyzon marinus (lamprey) cDNA LyEST8076 FD729689 tga-sel tgc-cys tag-stop not so virtual selenocys full 0 MSVHRYFDPEDHDLDKSFRLTKFSELKGuGCKVPQETLLKLLEGLEQDGPYQDEHQQFMGAVMPRL 1 2 GIGMDACVIPLRHGGLSLVQTTDFFYPLVDDPYMM 1 2 GKIACANVLSDLYAMGVTECDNMLMLLAISQKLSEK 0 0 ERDKVIPLMIRGFKDAAEEAGTTVTGGQTVVNPWIVIGGVATTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVNAHQWLDM 0 0 PEKWNKIKLVVTQEDVELAYQEAMFNMARLNRTAAGLMHTFNAH 2 1 AATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVIAKMAAISKACGNLFGLLQGTSAETSG 1 2 GLLICLPREQAARFCAEIaKYGEGHQAWIIGIVEKGGRTARIIDKPRIIEVAPRGASPTGVASPDTPTGPPLT* 0 >SEPHS1_eptBur Eptatretus burgeri (hagfish) cdna BJ649814 BJ654390 tga-sel taa-stop full 0 MSVHRYFDPEDHELDKSFRLTKFSDLKGuGCKVPQESLLKLLEGLEQDSPFQDEHQQFMGAVMPRL 1 2 GIGMDSCVIPLRHGGLSLVQTTDFFYPLVDDPYMM 0 0 GKIACANVLSDLYAMGVTDCDNMLMLLGISQKLSEK 0 0 ERDKVVPLMVRGFKDAAEEAGTTVTGGQTVMNPWIIIGGVASTVCQPNEFIM 2 1 PDNAVPGDVLVLTKPLGTQVAVAVHQWLDI 0 0 PEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAH 1 2 AATDITGFGILGHAQNLARQQRNEVAFVIHNLPRNEVAFVIHNLPVVAKMAAISKACGNLFGLLQGTSAETSG 1 2 GLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGARTARIIDKPRIIEVAPRGAPPPTVTTPTTPTAPLS* 0 >SEPHS1_braFlo Branchiostoma floridae (amphioxus)tga confirmed 73% hsa BW738890 BW748096 frag 0 MAAPEQVQQAVRPGRVFDPVAHGLDKSFRLTRFADLKuCCKVPQEVLLNLLEGLQNQTIPEEQGQFLPPHFAPI 1 2 GIGMDSCVVPLRQGGLSLVQTTDFFYPLVDDPYMQ 0 0 GKIACANVLSDLYAMGVKTCDNMLMLLGVSNKMSDK 0 0 ERDTVVPLIIRGFKDLAEEAGTMVQGGQTVLNPWVTIGGVATTVCPPNEFIE 2 1 PGNAVVGDVLVLTKPLGTQVAVNAHQWLDE 0 0 PERWNRIRLVVSEEDVERAYQESMFLMSKLNRT 1 2 AAKLMHKYNAHGATDITGFGLLGHAKNLVQHQKNEVSFTIHNLPVIAKMAAVAKACGNMFQLLQGYSAETS 1 2 * 0
SEPHS2: 8 vertebrate sequences
>SEPHS2_hsa human 1 exon but intronated like SEPHS1 for comparison MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGuGCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPAL GIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMM GRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEE EKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIM PDSAVVGDVLVLTKPLGTQVAVNAHQWLDN PERWNKVKMVVSREEVELAYQEAMFNMATLNRT AAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRFGLLQGTSAETS GGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGATAAVLAPDSSNASSEPSS* >SEPHS2_musMus Mus musculus (mouse) 1 exon MAEAAAAGASGETMAALVAAEGSLGPAGWSAGRSFSNYRPFEPQTLGFSPSWRLTSFSGMKGuGCKVPQETLLKLLEGLTRPALQPPLTSGLVGGQEETVQEGGLSTRPGPGSAFPSL SIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMM GRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEKER EKVTPLMIKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQQNEFIM PDSAVVGDVLVLTKPLGTQVAANAHQWLDN PEKWNKIKMVVSREEVELAYQEAMFNMATLNRT AAGLMHTFNAHAATDITGFGILGHSQNLAKQQKNEVSFVIHNLPIIAKMAAISKASGRFGLLQGTSAETS GGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGASAAAAAAPDNSNAASEPSS* >SEPHS2_laf Loxodonta africanus 1 exon MAEAAATGASGEAMAVAEGSSGPAGFSLGRGFSSYRPFEPQALGLNPSWRLTGFSGMKGuGCKVPQETLLKLLAGLTRPDMRPPLGRTLVEGHEEAIQEAGLPAGSGPSPTLPSL GIGLDSCVIPLRHGGLSLIQTTDFFYPLVEDPYMM GRIACANVLSDLYAMGITECDNMLMLLSVSQNMSEE EREKVTPLMIKGFRDAAEEGGTAVTGGQTVINPWIIIGGVATVVCQPNEFIM PDSAVVGDVLVLTKPLGTQVAVNAHQWLDN PERWNKIKMVVSREEVELAYQEAMFNMATLNRT AAGLMHTFNAHAATDITGFGILGHSQNLARQQRNEVSFVIHNLPIIAKMAAISKASGRFGLLQGTSAETS GGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGTTATTLVPDNFNASSEPTL* >SEPHS2a_monDom Monodelphis domestica (opossum) processed 1 exon processed MAAAAAATVGNGACTPATGGSLAGSYRPFEPQALGLSPNWRLTSFSDMKG uGCK VPQETLLTLLAGLTRPEERPPRAPGLNLGFGDVVAEEAAGPAVLEPGPDAGPFLPSAAGPSLPSPTL GIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMM GRIACANVLSDLYAMGITECDNMLMLLSVSQKMNEE EREKVMPLMIKGFRDAAEEGGTSVTGGQTVVNPWIIIGGVATVVCQPNEFIM PDSAVPGDVLVLTKPLGTQVAVNAHQWLDN PEKWNKIKLVVTREDVELAYQEAMFSMAMLNRT AAGLMHTFNAHAATDVTGFGILGHAQNLAKQQRSQVSFVIHNLPIIAKMAAISKASGRFGLLQGTSAETS GGLLICLPREHAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPGIIEVTPRGATVPLHPNNSHASLEPGS* >SEPHS2a_macEug Macropus eugenii (wallaby) 1 exon processed MRRRQRTVRTEAVTPAVGGSFAGSYSPFEPQSLGLSPNRRLTSFSDMKGuGCKVPQEALLTLLAGLTRPEERPPRAPGLGLGFGDSAAEEAAGPAAPEPGPDAGPFLAPAAGASPSPPTL GIGMDSCVIPLRHGGLSLVQTTDFFYPLMEDPYMM GRIACANVLSDLYAMGITECDNMLMLLSVSQKMNEE EKEKIMPLMIKGFRDAAEEGGTSVTGGQTVINPWIIIGGVATVVCQPNEFIM PDSAVPGDVLVLTKPLGTQVAVNAHQWLDNPERWNKIKLVVTREDVELAYQEAMFNMAMLNRT AAGLMHTFNAHAATDVTGFGILGHAQNLAKQQRSQVSFVIHNLPIIAKMAAISKASGRFGLLQGTSAETS GGLLICLPREHAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPGIIEVTPRGATVPLHPNNSHASLEPGS* 0 >SEPHS2b_monDom Monodelphis domestica (opossum)unprocessed 8 exons no syntenty to 1 frag 0 MASVPPRAPAAEGAGAASPGAYRPFEPKALGLSPSWRLTGFSELKGuGCKVPPEALLTLLASLTAAPAPAADRGN 1 2 GIGMDSCVVPLRHGGLSLVQTTDFFYPLVEDPYMM 0 0 GRIACANVLSDLYAMGITECDNMLMLLSVSQKMSEE 0 0 EREKIMPLMVRGFRDAAEQGGTSVTGGHTVINPWLIIGGVATSVCQPNEFIM 2 1 0 0 PEKWNKIKLVVSKEDVELAYQEAMFSMAMLNRT 1 2 AARLMHTFNAHAATDITGFGILGHAQNLAKQQRSEVSFVIHNLPIIAKMAAVSKASGCFGLLQGTSAETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPRIIEVMPRGATLHQDNSNTSPEPAL* 0 >SEPHS2b_macEug Macropus eugenii (wallaby) unprocessed 0 MAAAPPPPPPPLAAEGASAGAGARSQGAYRPFEPQALGLSPSWRLTGFSELKGuGCKVPQEALLTLLAGLARPPVAPAPDGGD 1 2 GIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMM 0 0 GRIACANVLSDLYAMGITDCDNMLMLLSISQKMNEE 0 0 EREKIMPLMVKGFRDAAEEGGTSVTGGHTVINPWIIIGGVATVVCQSNEFIM 2 1 0 0 PERWNKIKLVVSKEDVELAYQEAMFSMAMLNRT 1 2 AARLMHTFNAHAATDITGFGILGHAQNLAKQQRSEVSFVIHNLPIIAKMAAVSKASGCFGLLQGTSAETS 1 2 GGLLICLPREQ AARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPRIIEVMPRGAALHHDSSNTSPEPAS* 0 >SEPHS2_ornAna Ornithorhynchus anatinus (platypus) tga confirmed 0 FDPELLGLSPSWRLTGFSELKGuGCKVPQETLLKLLAGLTHPDPRPGAAPPDPQDPPPDPQDRTPHHAGPAPPAL 1 2 GIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMM 0 0 GRIACANVLSDLYALGITECDNMLMLLSVSQKMNEE 0 0 EREKIMPLMIKGFRDAAEEGGTSVTGGQTVVNPWIIIGGVATVVCQPNEFIM 2 0 PDNAVPGDVLVLTKPLGTQVAVNAHQWLDN 0 0 PEKWNKIKLVVSREDVELAYQEAMFSMAMLNRT 1 2 AAGLMHTFNAHAATDITGFGILGHAQNLAKQQRSEVSFVIHNLPIIAKMAAITKACGNRFGLLQGTSSETS 1 2 GGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPRIIEVTPRGAAAPPPDNNSSASPETGS* 0 >SEPHS2_tacAcu Tachyglossus aculeatus (echidna) EUPZL4S02I1W5B 454 0 KLVVSREDVELAYQEAMFSMAMLNRT 1 2 AAGLMHTFNAHAATDI >SEPHS2_galGal Gallus gallus (chicken) frag 0 MAAPPGPSVPSPTPGPSPGSGCALGPSTSYRPFDPTSLGLDPNWRLTSYSELRGuGCKVPEETLLRLLEGLGGPRSGAAAAAAAAGGGDGEGAEPGGAPTL 1 2 GIGTDCCVIPLRHGGLSLVQTTDFFYPLVDDPYMM 0 0 GRIACANVLSDLYAMGITECDNMLMLLSVSQKMTDE 0 0 ERDKVMPLIVRGFRDAAEAAGTSVTGGQTVLNPWVIVGGAASVVCQRQEFIV 2 1 PDSAVPGDVLVLTKPLGTQVAVTAHQWLDN 0 0 PERWNKIKLVVTREEVEAAYREAMFSMATLNRT 1 2 AAGLMHTFNAHAATDITGFGILGMHKNLAKQQRNEVSLLFTSLPVLAKNGCCQMAAVSKGLWQYCLGLYSLELVPETS 1 2 GGLLICLPREQAARFCAE >SEPHS2_xenTro Xenopus tropicalis (frog) 8 exons in genome 0 maAPGASHLSAACPFFPGYRPFDPVSVGLEASFRLTSFSDLKGuGCKVPRETLLRLLTGLTEEEAAVSGGAIRDPDVPCAGQDGGQNRL 1 2 GIGLDSCVIPLRHRGLSLVQTTDFFYPSVEDPYMQ 0 0 GRIACANVLSDLYAMGITECDNMLMLLSVSQKMTEE 0 0 EREKVTPLMIKGFRDAAEEGGTSVTGGQTVVNPWIIIGGVATVVCQANEFIM 2 1 PQNAVAGDVLVLTKPLGTQVAVNAHQWLDN 0 0 PERWNKIRLVVSREDVELAYQEAHVNMATLNRT 1 2 AAALMHSFNAHAATDVTGFGILGHAQNLAQEQQNEVSFVIHNLPIIAKAAITKACGNRFgLLQGTSPETS 1 2 GGLLICLPREQAARFCAEIKSPKHGEGHQAWIIGIVEKGNRSARIIEKPRiiEVTPRGAaTSDNTA* 0
TR1
TR3
TGR
GPX1 glutathione peroxidase from 24 vertebrates
>GPX1_homSap Homo sapiens (human) chr3 2 exons glutathione peroxidase pseudo:chrX 0 MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA* 0 >GPX1_panTro Pan troglodytes (chimp) 0 MCAARLAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA* 0 >GPX1_macMul Macaca mulatta (rhesus) 0 MCAARLAAAAYAFSARPLAGGEPVSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPVRRYSRRFQTIDIEPDIEALLSQGPSSA* 0 >GPX1_tupBel Tupaia belangeri (tree_shrew) 0 MCAARRAAAAQAVYTFSARPLGAEEPMSLGSLRGKVLLIENVASLuGTTVRDYTQMNDLQRRLGIRSLVVLGFPCNQFRHQ 0 0 KSKNEEILKSLKYVRIGDGFEPNFTVFEKCEVNGAKAHPLFAFLREALPAPSDDPCALMTDPKFITWSPVCRNDIAWNFEKFLVGPDGVPVRRYSRRFPTIDIEPDIEALLSQGP* 0 >GPX1_musMus Mus musculus (mouse) 0 MCAARLSAAAVYAFSARPLTGGEPVSLGSLRGKVLLIENVASLuGTTIRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQ 0 0 ENGKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGEKAHPLFTFLRNALPTPSDDPTALMTDPKYIIWSPVCRNDIAWNFEKFLVGPDGVPVRRYSRRFRTIDIEPDIETLLSQQSGNS* 0 >GPX1_ratNor Rattus norvegicus (rat) 0 MSAARLSAVAVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLuGTTTRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQ 0 0 ENGKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGEKAHPLFTFLRNALPAPSDDPTALMTDPKYIIWSPVCRNDISWNFEKFLVGPDGVPVRRYSRRFRTIDIEPDIEALLSKQPSNP* 0 >GPX1_oryCun Oryctolagus cuniculus (rabbit) 0 MCAARMQSVYSFSAHPLAGGEPVNLGSLRGKVLLIENVASLuGTTVRDYTQMNELQERLGPRGLVVLGFPCNQFGH. 0 0 ENAKNEEILNSLKYVRPGGGFEPNFMLFQKCEVNGAKAHPLFAFLREALPAPSDDPTALMTDPKFITWSPVCRNDVSWNFEKFLVGPDGVPVRRYSRRFPTIDIEPDIQALLSKGSGGA* 0 >GPX1_canFam Canis familiaris (dog) 0 MCAAALAAAAPSVYAFSARPLAGGEPMSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGAQAHPLFAFLRESLPAPSDDTTALMTDPKFITWSPVCRNDVAWNFEKFLVGPDGVPVRRYSRRFPTIDIEPDIEALLSQGPSCA* 0 >GPX1_felCat Felis catus (cat) 0 MCAAPLAAAAPSVYSFSARPLAGGEPMSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGAQAHPLFAFLRQALPAPSDDATALMTDPKFITWSPVCRNDVAWNFEKFLVGPDGVPVRRYSRRFPTIDIEPDIEALLSQGPSCA* 0 >GPX1_equCab Equus caballus (horse) 0 MCAAQLAAARSVYAFSARPLAGGEPLSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGAQAHPLFAFLREALPAPSDDATALMTDPKFITWSPVCRNDVAWNFEKFLVGPDGVPVRRYSRRFPTIDIEPDIEALLTQGPSCA* 0 >GPX1_bosTau Bos taurus (cow) 0 MCAAQRSAAAPTVYAFSARPLAGGEPFNLSSLRGKVLLIENVASLuGTTVRDYTQMNDLQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNCLKYVRPGGGFEPNFMLFEKCEVNGEKAHPLFAFLREVLPTPSDDATALMTDPKFITWSPVCRNDVSWNFEKFLVGPDGVPVRRYSRRFLTIDIEPDIETLLSQGASA* 0 >GPX1_eriEur Erinaceus europaeus (hedgehog) 0 MCAAPAAAQSVHAFSARPLVGGEPISLGSLQGKVLLIENVASLuGTTVRDYTQMNELQQRFGPRGLVVLGFPCNQFGHQ 0 0 ENTKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAQAHPLFAFLREALPAPSDDATSLMTDPKLITWSPVCRNDVSWNFEKFLVGPDGVPVRRYSRRFPTIDIQPDIEALLAKQPLSS* 0 >GPX1_sorAra Sorex araneus (shrew) 0 MCAAPAAAAMAAQRSVHAFSARPLVGGEPISLGSLQGKVLLIENVASLUGTTVRDYTQMNELQQRFGPRGLVVLGFPCNQFGHQ 0 0 ENTKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAQAHPLFAFLREALPAPSDDATSLMTDPKLITWSPVCRNDVSWNFEKFLVGPDGVPVRRYSRRFPTIDIQPDIEALLAKQPLSS* 0 >GPX1_dasNov Dasypus novemcinctus (armadillo) 0 MCAAALSAAQSVHAFSARPLAGGEPVSLGSLRGKVLLIENVASLuGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENAKNEEILNCLKYVRPGGGFEPNFMLFEKCDVNGAQAHPLFAFLREALPAPSDDATALMTDPKFIIWSPVCRNDVAWNFEKFLVGPDGVPVRRYSRRFPTIDIESDIEALLSQGPSCA* 0 >GPX1_loxAfr Loxodonta africana (elephant) 0 MCAAPVAAALSVHAFSARPLAGGEPVNLGSLRGKVLLIENVASLuGTTVRDYTQMNDLQRRLGPRGLVVLGFPCNQFGHQ 0 0 ENGNKEEILNSLKYVRPGGGFEPNFTLFEKCEVNGAQAHPLFAFLREALPAPSDDATALMTDPKFIIWSPVCRNDISWNFEKFLVGPDGVPVRRYSRRFPTIDIEADIEALLSKGPSCA* 0 >GPX1_monDom Monodelphis domestica (opossum) 0 MCAARSVHAFSARLLGSGELLSLASLRGKVLLIENVASLuGTTIRDYTQMNELQKRHGGRGFMVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKFVRPGSGFEPNFMLFEKCEVNGEKAHPLFTFLREALPAPSDDTNSLMTDPKLIIWSPVCRNDISWNFEKFLVGPDGVPVKRYSRRFETINIEKDIEDLLTKMPKEV* 0 >GPX1_ornAna Ornithorhynchus anatinus (platypus) 0 MCASQSVYGFSGRLLRSGEPFSLAALRGKVLLIENVASLuGTTVRDYTQMNELQSLYGPRGLAVLGFPCNQFGHQ 0 0 ENAKNEEILNSLKYVRPGNGFEPNFTMFEKCEVNGEKAHPLFAFLRESLPTPSDDPTSLMNDPKFITWSPVCRNDISWNFEKFLVGPDGVPVKRYSRRFETINIKEDIEVLLGQMSSYFQ 0 >GPX1_galGal Gallus gallus (chicken) 0 MAATGLAGILARPLGAAEPLALSSLRGKVLLVVNVASLuGTTTRDFLQLNELQQRYGPRGLRVLGFPCNQFGHQ 0 0 ENATNEEILRSLEYVRPGNGFKPNFTMFEKCEVNGKGAHPLFAFLREALPFPHDDPSALMTNPQYIIWSPVCRNDVSWNFEKFLVGPDGVPFRRYSRHFETIKLQDDIELLQ* 0 >GPX1_anoCar Anolis carolinensis (lizard) taa-stop 0 MAGLPVRGLAGLLARPLGAKDPVDLGSSRGRVVLVSNVASLuGTTARDFTQFSELQRRFGPRGFVVLAFPCNQFGHQ 0 0 ENATNEEILNSLKYVRPGNGYEPNFTVFEKCEVNGENAHPLFKFLKDELPYPHDDAVSLMANPQNIIWSPVCRNDISWNFEKFLIGPDGKPFKRYSRRFETIKIQDDIEKLQ* 0 >GPX1_xenTro Xenopus tropicalis (frog) 0 MRLAMVSRTVYEFSARLLSAGENTALSQYKGRVLLIENVASLuGTTIRDYTQMSRLQSMYGPRGLQVLAFPCNQFGHQ 0 0 ENSGNQEILNILKHVRPGGGFEPNFPLFEKVDVNGEKEHPLFTFLKGQLPYPSDDSISLMQDPKSIIWSPVRRNDIAWNFEKFLIARNGVPYKRYGRRFETFNIQQDIEKLLSLSSAP. 0 >GPX1b_danRer Danio rerio (zebrafish) 0 MAGIKSFYDITAKTLTGEEFKFSSLQGKVVLIENVASLuGTTSRDYTQMNELHERFAEKGLVVLGVPCNQFGYQ 0 0 ENCTNEEILLSLKYVRPGNGYEPKFQLLEKVDVNGKNAHPLFTFLKEKLPFPSDEPMPFMSDPKFIIWSPVCRNDIAWNFEKFLIGSDGVPFKRYSRRFLTSGIDGDIKKLLSIP* 0 >GPX1_tetNig Tetraodon nigroviridis (pufferfish) 0 MAANFYDLTAKLLTGEAFNFSSLQGKVVLIENVASLuGTTTRDYTQMNELHERYASKGLVVLGVPCNQFGHQ 0 0 ENCKNEEILLSLKHVRPGHGFEPKFQLLEKVDVNGKDAHPLFQFLREKLPSPSDDPSALISDPKLIIWSPVCRNDVAWNFEKFLVGPDGVPFKRYSRKFLTSSIESDIKKLLSQA* 0 >GPX1_takRub Takifugu rubripes (fugu) 0 METQFYDLTAKLLTGEAFNFSSLQGKVVLIENVASLuGTTSRDYTQMNELHERYAGQGLVILGVPCNQFGHQ 0 0 ENCKNEEILSSLKYVRPGNGFEPKFQLFEKVDVNGKDAHPLFQFLREKLPFPSDDPTALMSDPKLINWSPVCRNDVSWNFEKFLIGPDGVPFKRYSRKFLTSSIEGDIKKLLSQA* 0 >GPX1_gasAcu Gasterosteus aculeatus (stickleback) 0 MARMAAKFYDLSAKLLTGETFNFSSLQGKVVNVASLuGTTSRDYTQMNELHERYAGKGLVILGVPCNQFGHQ 0 0 ENCKNEEILLSLKYVRPGNGFEPKFQLLEKVDVNGKDAHPLFVFLKGKLPYPSDEPGALMNDPKLILWSPVCRNDVSWNFEKFLIGSDGVPFKRYSRRFLTSDIEGDIKKLLSQA* 0 >GPX1_oryLap Oryzias latipes (medaka) 0 MASKFYSLTAKLLSGEIFNFSVLQGKVVLIENVASLuGTTTRDYTQMNELHERYASKGLVILGVPCNQFGHQ 0 0 ENCKNEEILLSLKHVRPGNGFEPKFQLLEKVDVNGKDAHPLFAFLREQLPTPSDDPAPLMTDPKFIIWSPVCRNDVAWNFEKFLVGPDGTPFKRYSRRFLTSDVEGDIKKLLSQT* 0
GPX2: 32 Vertebrate Sequences
>GPX2_homSap Homo sapiens (human) chr14 2 exons gastrointestinal glutathione peroxidase 2, U in cow pig rat chicken frog trout scorpion 0 MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLuGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_panTro Pan troglodytes (chimp) 0 MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_macMul Macaca mulatta (rhesus) 0 MAFIAKSFYGVSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPHDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_calJac Callithrix jacchus (marmoset) 0 MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 LQCGGIRQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_tarSyr Tarsius syrichta (tarsier) 0 MACIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQVSERQCRFPRRLVVLGFPCKQFGHQ 0 0 ...SRTVVDSYVRPGGGYQPTFTLLQKCDVNGQNEHPVFAYLKDKLPYPQDDPHSLMTDPKFIIWSPVRRSDVAWNFEKFLVGPEGEPFRRYSRTFPTISIEPDIKRLLKVAI* 0 >GPX2_otoGar Otolemur garnettii (galago) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLQYVRPGGGFQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPLTLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_micMur Microcebus murinus (mouse lemur) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKFVRPGGGYQPTFTLIQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFHTINIEPDIRRLLKVAI* 0 >GPX2_tupBel Tupaia belangeri (tree shrew) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLQYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_musMus Mus musculus (mouse) 0 MAYIAKSFYDLSAIGLDGEKIDFNTFRGRAVLIENVASLUGTTTRDYNQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGYQPTFSLTQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRSFQTINIEPDIKRLLKVAI* 0 >GPX2_ratNor Rattus norvegicus (rat) 0 MAYIAKSFYDLSAIGLDGEKIDFNTFRGRAVLIENVASLUGTTTRDYTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFSLTQKCDVNGQNQHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI* 0 >GPX2_cavPor Cavia porcellus (guinea pig) 0 MAYIAKSFYDLSAISLDGEKIDFNTFRGRAVLIENVASL>TTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ...AQCGGFSDVSWYFEKFLIGPEGEPFRRYSRTFHTINIEPDIKRLLKVAI* 0 >GPX2_speTri Spermophilus tridecemlineatus (squirrel) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNDLQCRFPRRLVVLGFPCNQFGHQ 0 0 0 >GPX2_ochPri Ochonta princeps (pika) 0 MAYIAKSFYDLTAISLDGEKVDFNTFRGRAVLIENVASLUGTTSRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLQYVRPGGGYQPTFTLVQKCEVNGQNQHPVFAYLKDKLPYPYDDPFSFMTDPRFILWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKLAI* 0 >GPX2_oryCun Oryctolagus cuniculus (rabbit) 0 MAYLAKSFYDLTAVSLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRYPRRLVVLGFPCNQFGHQ 0 0 ENCQDEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNQHPVFTYLKDKLPYPHDDPFSLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_canFam Canis familiaris (dog) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPLSLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_felCat Felis catus (cat) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_equCab Equus caballus (horse) 0 MAYIAKSFYDLSAISLDGEKIDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLVQKCEVNGQNQHPVFAYLKDKLPYPYDDPLSLMTDPKFIIWSPVCRSDVSWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_myoLuc Myotis lucifigus (brown bat) 0 MAFIAKSFYDLSAISLDGEKIDFNTFRGRAVLIENVASLUGTTTRDYTQLNELQCRYPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGDGFQPTFTLAQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKYIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI* 0 >GPX2_turTru Tursiops truncatus (dolphin) 0 MAYVAESFYDLSAISLDGEKVDFNTFRGMAVLIENVSSLUHNHRDFTQLNELQCRFPAPVILL... 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLIQKCDVNGQNEHPVFTYLKDKLPYPYDDPFSLMTDPKFIIWSPVHRSDVSWNFEKFLVGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_bosTau Bos taurus (cow) 0 MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLVQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI* 0 >GPX2_vicVic Vicugna vicugna (camel) 0 ...LDGEKVDFNTSRGRAVLIENVASLUGTTTRDYTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLVQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_eriEur Erinaceus europaeus (Euro hedgehog) 0 MAYIAKSFYDLSAISLDGEKIDFNTFRGRAVLIENVASLUGTTTRDYTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFTLAQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLLTDPKFIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEADIKRLLKVAI* 0 >GPX2_sorAra Sorex araneus (shrew) 0 MGKKIDFNTFRGRVVLIENVASLUGTTTRDYTQLNELQARFPRRLVVLGFPCNQFGHQ 0 0 0 >GPX2_dasNov Dasypus novemcinctus (armadillo) 0 MGKKIDFNTFRGRVVLIENVASLUGTTTRDYTQLNELQARFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGNDFQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKYIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_loxAfr Loxodonta africana (elephant) 0 MTHIAKSFYDLSAISLEGDKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCKNEEILNSLKYVRPGGGFQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPLSLMTDPKFIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI* 0 >GPX2_echTel Echinops telafair (hedgehog) 0 MAYIAKSFYDLSATSLDGDKIDFNAFRGRAVLIENVASLUGTTTRDYTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENSQNEEILNSLKYVRPGGGFQPTFTLAQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSFMTDPKFFIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFQTISIEPDIKRLLKVAI* 0 >GPX2_monDom Monodelphis domestica (opossum) 0 MAHIAKSFYDLSATSLEGERIDFNTFRGRAVLIENVASLUGTTTRDYTQLNELQCRFPRRLVILGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGAGFQPNFVLVQKCEVNGQNEHPVFAYLKDKLPYPDDDPFSLMTDPKHIIWSPVRRSDIAWNFEKFLVGPEGEPFRRYSRSFQTINIEPDIKRLLKVAI* 0 >GPX2_ornAna Ornithorhynchus anatinus (platypus) 0 MARIAKSFYDLSATSLNGEKVDFNTFRGRAVLIENVASLUGTTTRDYTQLNELQRLFPRRLVILGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGNGFEPHFVLIQKCEVNGQNEHPVFSYLKAKLPYPEDDPSALMTDPKLIIWSPVRRSDVAWNFEKFLVGPEGEPFRRYSRTFPTIDIEPDIKRLLKVAI* 0 >GPX2_galGal Gallus gallus (chicken) chicken cDNA missing genome 0 MSVPIAKSFYDLSATSLQGEKIDFNTFRGRAVLIENVASLuGTTTRDYTQLNELQCRFPRRLVVLGFPCNQFGHQ 0 0 ENCQNEEILNSLKYVRPGGGFQPTFSLTQKCDVNGQNQHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI* 0 >GPX2_xenTro Xenopus tropicalis (frog) cDNA 0 MAYIAKSFYDLYATNIDGEKVDFNVFRGRVVLIENVASLuDTTVRDYTQLNELQTKYPRRLVVLGFPCNQFGYQ 0 0 ENCKNEEILNSLKYVRPGKGFVPGFTLFQKCDVNGKDTHSVFAYLKDKLPVPDNEPAALISDPRYIVWNPVHRSDISWNFEKFLIGPEGEPFKRYNKNFQTISIEPDIQRLLKLTKHLELCVCMYATDNYYMAAHKKI* 0 >GPX2_calMil Callorhinchus milii (elephantfish) tga-cys tag-stop full 0 MANSRKFYGFSTKLLNGQTLNFSKFKGKVVLIENVASLuGTTARDYTQMNELQSRYSREGFAVLGFPCNQFGFQ 0 0 ENCKNDEILKTLKYVRPGGGYEPNFTMFQKSIVNGDGTHPLFAYLKEKLPYPDDDPVSFMKDPQSINWSPVCRSDISWNFEKFLIGPDGEPFKRYSKKFETIQIEPDIQRLLKVAK* 0 >GPX2_petMar Petromyzon marinus (lamprey) cDNA LyEST1379 tga-sel tag-stop full 0 MKSFYELSAKTLGGELVSFSRYRGKVVLVENVASLuGTTTRDFTQLNELQGRYGAQGLAVLGFPCNQFGHQ 0 0 ENSQNEEILNTLKYVRPGSGYEPNFTMFAKCEVNGKDTHPVFEFLKEKLPLPSDDPISFLQDPKHIIWSPVSRSDIAWNFEKFLVGPDGQPFKRYSKKFQTINIEEDLKFLLKQVK* 0
GPX3
>GPX3_homSap Homo sapiens (human) chr5 5 exons plasma glutathione peroxidase 3 0 MARLLQASCLLSLLLAGFVSQSRGQEKSK 0 0 MDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYuGLTGQYI 1 2 ELNALQEELAPFGLVILGfpcnqfgKQEPGENSEILPTLK 2 1 YVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLK 0 0 NSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK* 0 >GPX3_galGal Gallus gallus (chicken) genomic 0 MGCRAACVLAVLLAGLVPLGQGQEREK 0 0 VKCYDSVRGTIYDYGALTIDGDEYIPFRKYAGKMVLFVNVATYuGLTLQYL 1 2 ELNALQNELGPYGLVVLGFPSNQFGKQEPGQNSEILPALK 2 1 YVRPGGGFVPNFQLFQKGDVNGAKEQKVYSFLK 0 0 nSCPPVAEEFGNPKNLFWEPLRNHDIKWNFEKFLVGTDGVPVMRWYPPRQHRHCQERHHPLHAAAAGPVAPPAHPPCNPRPGPGEQRMTSP* 0
GPX4
>GPX4_homSap Homo sapiens (human) at chr19:10549651057778 7 exons glutathione peroxidase 4 0 MSLGRLCRLLKPALLCGALAAPGLAGTM 0 0 CASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 2 1 GFVCIVTNVASQuGKTEVNYTQLVDLHARYAECGLRILAfpcnqfgKQ 0 0 EPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILG 2 1 NAIKWNFTK 0 0 FLIDKNGCVVKRYGPMEEPL 0 0 VIEKDLPHYF* 0
GPX5
>GPX5_homSap Homo sapiens (human) at chr65 exons C not U inverted tandem pair back to elephant; not in opossum, chicken 0 MTTQLRVVHLLPLLLACFVQTSPKQEKMK 0 0 MDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYcGLTAQYP 1 2 ELNALQEELKPYGLVVLGfpcnqfgKQEPGDNKEILPGLK 2 1 YVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLK 0 0 HSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK* 0
GPX6
>GPX6_homSap Homo sapiens (human) at chr6 5 exons 6 tail-to-tail tandem with GPX5 66% identity 0 MFQQFQASCLVLFFLVGFAQQTLKPQNRK 0 0 VDCNKGVTGTIYEYGALTLNGEEYIQFKQFAGKHVLFVNVAAYuGLAAQYP 1 2 ELNALQEELKNFGVIVLAfpcnqfgKQEPGTNSEILLGLK 2 1 YVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLK 0 0 NSCPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYLKQFNTH* 0
GPX7
>GPX7_homSap Homo sapiens (human) chr1:5243796152444640 3 exons 7 no genomic U 0 MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGS 0 0 VSLVVNVASEcGFTDQHYRALQQLQRDLGPHHFNVLAFPCNFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYL 1 2 QTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL* 0
SELS
>SELS_homSap Homo sapiens (human) 6 exons 0 MERQEESLSARPALETEGLRFLHTT 1 2 VGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQRQLDRAAAAV 1 2 EPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQ 0 0 LEEEKRRQKIEMWDSMQEGKSYKGNAKKPQ 0 0 EEDSPGPSTSSVLKRKSDRKPLRGG 1 2 GYNPLSGEGGGACSWRPGRRGPSSGGuG* 0
SELI
>SELI_homSap Homo sapiens (human) chr2 0 MAGYEYVSPEQLAGFDKYK 0 0 YSAVDTNPLSLYVMHPFWNTIVK 0 0 VFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYAS 1 2 APGHKHVPDWVWIVVGILNFVAYTL 1 2 DGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQV 0 0 TISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMII 1 2 GCALCVTLPMSLLNFFR 2 1 SYKNNTLKLNSVYEAMVPLFSPCLLFILSTAWILWSPSDILELHPRVFYFMVGTAFANST 0 0 CQLIVCQMSSTRCPTLNWLLVPLFLVVLVVNLGVASYVESILLYTLTTAFTLAHIHYGVRV 0 0 VKQLSSHFQIYPFSLRKPNSDuLGMEEKNIGL* 0 >SELI_ornAna Ornithorhynchus anatinus (platypus) 53% LOC100086265 0 MAGYEYVSAEQLAGFDKYK 0 0 YSALDTNPLSLYVMHPFWNTIVKV 0 0 IFPTWLAPNLITFSGFLLLVFNFLLMAYFDPDFYAS 1 2 APGQKHVPDWVWIVVGILNFTAYTL 1 2 DGVDGKQARRTNSSTPLGELFDHGLDSWACVYFVVTVYSIFGRGRTGVSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDMSQV 0 0 TISIVYIVTAVVGVEAWYEPFLFNFLYRDLFTTMII 1 2 GCAVTVTLPMSLYNF 2 1 AYRNKTLKYSSVYETMLPFVSPCLLFTLSTTWIFLSPSNILETHPRLFYFMVGTLFANIT 0 0 CQLIVCQMSNTRCQPLNWLLMPLALVILVVHSGLAPHSETFLLYSLTALVTVAHIHYGIRV 0 0 VNQLSKHFKILPFSLRKPSSDuLGLEEEKIGL* 0
SELT: 11 vertebrate sequences
>SELT_homSap Homo sapiens (human) 5 exons recent pseudogenes on chr 5, chr9 0 MQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_macMul Macaca mulatta (rhesus) 0 MRLLLLLLVAASAMVRSEASANLGGVPSKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_otoGar Otolemur garnettii (bushbaby) 0 MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIIGKIYSLHHSYR 2 1 HIASFLSIFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_musMus Mus musculus (mouse) 0 MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_ratNor Rattus norvegicus (rat) 0 MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_bosTau Bos taurus (cow) 0 MRLLLLLLVAASAVVRSDASANLGGVPGKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_canFam Canis familiaris (dog) 0 MRYLLVLLVAASAVIRSDASANLGGVPSKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_monDom Monodelphis domestica (opossum) 0 MRFLLLLLMAAAAL-QGEASADTGGVPGKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 IYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHH*SQ * 0 >SELT_ornAna Ornithorhynchus anatinus (platypus) 0 MRLLLLVVVAAAAGGRSEASADLGGLPSKRLKMQYATGPLLKFQIC 2 1 VSuGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYR 2 1 HIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENK 0 0 VYACMMVFFLSNMIENQCMSTGAFEITLN 1 2 DVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS* 0 >SELT_petMar Petromyzon marinus (lamprey) cDNA EE737658 tga-sel tag-stop full 0 MRTHLFAGPVLKVEYC 2 1 VSuGYRRVFEEYSRVIAERFPDIRVEGDNYLPQPLYR 2 1 YIASFFSVFKLVLIGLVLSGKNLFPMLGVDTPGVWTWSQENK 0 0 LYACLMIFFVSNMVETQCMSTGAFEVSLN 1 2 DVPVWSKLQSGRVPSPQEILQILDNHVKLSGGSAGRMQPS* 0 >SELT_eptBur Eptatretus burgeri (hagfish) cdna BJ650136 tga-sel tag-stop full 0 MKSKMYSGPELLFQYC 2 1 ISuGYRRVFEEYSQALRERYPDIRIEGSNYPPPPLYS 2 1 TCASVLSVLKVMLIVLVVSGRNPFPLLGLDTPNAWNWSQNNK 0 0 IYACLMIFFLTNMIENQCLSTGAFEVVFN 1 2 DVPIWSKLQSGRVPSLPELAQILDNHLAMGGQASPSNTHGPQ* 0
SEP15: 6 vertebrate sequences
>SEP15_homSap Homo sapiens (human) 0 MAAGPSGCLVPAFGLRLLLATVLQA 0 0 VSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKK 0 0 LYAGAILEVCGuKLGRFPQVQ 1 2 AFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI* 0 >SEP15_susScr Sus scrofa (pig) 0 MAAEPGGWLGPALGLRLLLATALQM 0 0 VSAFGAEFSSESCRELGFSSNLLCGSCDLLGQFDLLQLDPDCRGCCQEEAQFETKK 0 0 LYAGAILEVCGUKLGRFPQVQ 1 2 AFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLQR* 0 >SEP15_ornAna Ornithorhynchus anatinus (platypus) EG339469 0 MAAAEAAVMAPWLRLFLAATLQA 0 0 ISAYGTELSSEACRDLGFSSNLLCSSCDLLGQFSLTQLDPVCRGCCQEEAQFESRK 0 0 LYAGAILEVCGuKLGRFPQVQ 1 2 AFVRSDKPKLFRGLQIKYVRGSDPVLKLLDESGNIAEELSILKWNTDSVEEFLSEKLERI* 0 >SEP15_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01BKAWJ EUEMSW404CBHS5 454 0 LGFSSNLLCSSCDLLGQFSLTQLDPSCRGCCQEEAQFESRK 0 0 LYAGAILEVCGuKLGRFPQVQ 1 2 AFVRSDKPKLFRGLQIKYVHGSDPVLKLLDESGNIAEELSILKWNTDSVEEFLSEKLERI* 0 >SEP15_petMar Petromyzon marinus (lamprey) cDNA EG333213 tga-sel taa-stop full 0 MAAVRPGLLLLLLKAVS 0 0 VYATELTSEACRDLGFSSNLLCSSCDLLSQFGLDQLDPGCKRCCQLEVEESALK 0 0 LYPGAVLEVCGuKLGRFPQVQ 1 2 AFVRSNKPSTFKGLTIKYVRGSDPVLKLLDESGNVAEELSITKWNTDSVEEFLSEKLERL* 0 >SEP15_eptBur Eptatretus burgeri (hagfish) BJ647169 tga-sel taa-stop 0 FGTRLGAGSFLALCLVS 0 0 VSAAELSSEVCRDRGFSSGLVCSSCDLLAQFDLHRLDPDCRSCCQPEVEEQEIKR 0 0 YAGAVLEVCGuKLGRFPQVQ 1 2 AFVKSNKPSTFKGLTTK 0 0 YVRGADPVLKLLDQDGNVAEELSITKWNTDSVEEFLSENLERL* 0
SEPP1 (SELP): 15 vertebrate sequences
>SEPP1_homSap Homo sapiens (human) chr5 4 exons 10 selenocysteines 0 MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASuYLCILQASK 2 1 LEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDR 2 1 CGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLT 0 0 TLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGH PENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSuCCHCRHLIFEKTGSAITuQCKENLPSLCSuQGLRAEEN ITESCQuRLPPAAuQISQQLIPTEASASuRuKNQAKKuEuPSN* 0 >SEPP1_panTro Pan troglodytes (chimp) 0 MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSSGSVTVVALLQASuYLCILQASK 2 1 LEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDR 2 1 CGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLT 0 0 TLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQH RQGHPENQDMPGSEDLQDLQKKLCRKRCINQLLCKLPKDSELAPRSCCCHCRHLIFEKTGSAITuQCKENLPSLCSu QGLRAEENITESCQuRLPPAAuQISQQLIPTEASTSuCuKNQAKKuEuPSN* 0 >SEPP1_ponPyg Pongo pygmaeus (orang_sumatran) 0 MWRSLGLALALCLLPLGGTESQDQSSLCKQPPAWSIRDQGPMLNSNGSVTVVALLQASuYLCILQASK 2 1 LEDLRVKLKKEGYSNISHIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDR 2 1 CGRLVYHLGLPFSFLTFPYVEEAVKIAYCEKKCGYCSLT 0 0 TLKDEDFCKSVSLATVDKTVEAPSPHYHHEHHHNHRHQHLGSSELSENQQPGAPDAPTHPAPPGLHHHHKHKGQH RQGHPENRDMPGSEDIQDLQKKLCRKRCINQLLCKLPKDSELAPRSCCCHCRHLIFEKTGSAITuQCKENLPSLCSu QGLRAEENITESCQuRLPPPAuQISQQLIPTEASTSuRuKNQAKKuEuPSN* 0 >SEPP1_macMul Macaca mulatta (rhesus) 0 MWRSLGLALALCLLPSGGTESQDQSSFCKQPPAWSIRDQDPMLDSNGSVTVVALLQASuYLCILQASK 2 1 LEELRVKLEKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDR 2 1 CGLLVYHLGLPFSFLTLPYVEEAIKIVYCEKKCGNCSLT 0 0 TLKDEDFCKSVSLATVDETVEAPQAHYHHEHHHNQGHQSSELSENQQPGAPGAPTHPAPPGLHHHHKHKGQHRQGH PESuDMPGSEGLQHLQKKLuRKRCINQLLCKLPKDSELAPRSuCCHCRHLIFEKTGSAITuQCKENLPSLCSuQGLLAEET* 0 >SEPP1_musMus Mus musculus (mouse) 0 MWRSLGLALALCLLPYGGAESQGQSSACYKAPEWYIGDQNPMLNSEGKVTVVALLQASuYLCLLQASR 2 1 LEDLRIKLESQGYFNISYIVVNHQGSPSQLKHSHLKKQVSEHIAVYRQEEDGIDVWTLLNGNKDDFLIYDR 2 1 CGRLVYHLGLPYSFLTFPYVEEAIKIAYCEERCGNCNLT 0 0 SLEDEDFCKTVTSATANKTAEPSEAHSHHKHHNKHGQEHLGSSKPSENQQPGPSETTLPPSGLHHHHRHRGQHRQGH LESuDTTASEGLHLSLAQRKLuRRGCINQLLCKLSKESEAAPSSCCCHCRHLIFEKSGSAIAuQCuENLPSLCSuQGLF AEEKVTESCQCRSPPAAuQNQPMNPMEANPNuSuDNQTRKuKuHSN* 0 >SEPP1_ratNor Rattus norvegicus (rat) 0 MWRSLGLALALCLLPYGGAESQGQSPACKQAPPWNIGDQNPMLNSEGTVTVVALLQASuYLCLLQASR 2 1 LEDLRIKLENQGYFNISYIVVNHQGSPSQLKHAHLKKQVSDHIAVYRQDEHQTDVWTLLNGNKDDFLIYDR 2 1 CGRLVYHLGLPYSFLTFPYVEEAIKIAYCEKRCGNCSFT 0 0 SLEDEAFCKNVSSATASKTTEPSEEHNHHKHHDKHGHEHLGSSKPSENQQPGALDVETSLPPSGLHHHHHHHKHKGQH RQGHLESuDMGASEGLQLSLAQRKLuRRGCINQLLCKLSEESGAATSSCCCHCRHLIFEKSGSAITuQCAENLPSLCSuQ GLFAEEKVIESCQCRSPPAAuHSQHVSPTEASPNuSuNNKTKKuKuNLN* 0 >SEPP1_canFam Canis familiaris (dog) 0 MWRSLGLALALCLLPWGGAESQGQSSFCKQPPAWSIRDQNPMLNSSGSVTVVALLQASuYLCILQASR 2 1 LEDLRVKLEKEGFLNISYVVVNHQGLSSQLKYMYLKNKVSEHIPVYQQEENQTDVWTLLNGKKDDFLIYDR 2 1 CGRLVYHLGLPYSFLTFPYVEEAIKRAYCEEKCGNCSLT 0 0 VLEDEEVCKMVSSGTVESTTEAPQPHPHDHHLHHHHHHHHKHWHRLMPHGNDELSENQQPEEPDVSEHPAPQGLHRHHKHKDHQRQGH PDNuDMPAGSESLQLSVPQNQLuRKGCRNQLLCKLPRDSGLAPSSuCuHuRHLIFEKTGSAITuQCKETLPSLCSuQGLWAEENVIESuQ uRWPPAAuQASQQLRPTEASTNuSuKYKTKMuKuLTY* 0 >SEPP1_equCab Equus caballus (horse) 0 MWRSLGLALALCLLPWGGTESQGQSSFCKQPPAWSIRDQDPMLNSYGSVTVVALLQASuYLCLLQASR 2 1 LEDLRVKLEKEGYSNISYVVVNHQEISARLKYIHLKNKVSEYIAVYQQEENQTDIWTLLNGSKDDFLIYDR 2 1 CGRLVYHLGLPYSFLTFPYVEEAIKIAYCEKKCGNCSLM 0 0 TLEDEDFCKTLSLATVEKTTEDSQPHHHHHHQHHHKHGHQHVGNSQLSENQQPEATGAPEHPPPPGLHHHHKHKGQQ RRGHPENuDMPGGESLQLSLPQKKLuQKGCINQLLCKMPKDSKLAPSSuCuHCRHLIFENTRSAITuQCTENLPSLCSuQ GLWAEENVIESCQuRLPPAAuQPS-QQLKPTEASTNuSuKYKAAMuKuPSN* 0 >SEPP1_bosTau Bos taurus (cow) 12 sel 0 MWRGLGLALALCLLLTGGTESQGQSSYCKQPPPWSIKDQDPMLNSYGSVTVVALLQASuYLCILQASR 2 1 LEDLRVKLEKEGYSNISYVVVNHQGISSRLKYVHLKNKVSEHIPVYQQEENQPDVWTLLNGNKDDFLIYDR 2 1 CGRLVYHLGLPYSFLTFTYVEDSIKTVYCEDKCGNCSLS 0 0 RPQDEDVCKNVFLATKEKTAEASQRHHHPHPHSHPHPHPHPHPHPHPHPHHGHQLHENAHLSESPKPDTPDTPENPPTSGLHHHHHRHKGPQRQGH SDNCDTPLGSESLQPSLPQKKLuRKRCINQLLuQFPKYSESALSSCCCHCRHLVFEKTGSAITuQCTEKLPSLCSuQGLLAEENVIESuQuRLPPAAu QAAGQQLNPTEASTKuSuKNKAKMuKuPSN* 0 >SEPP1_choHof Choloepus hoffmanni (sloth) 0 MWKSLGLALALCLLPWGGTESQEQSPFCKRPPAWTIRGQDPMLNSNGSVTVVALLQASuYLCILQASR 2 1 LEDLRVKLEKEGYSNISYIIVNHHEITSQLKYIHLKNKVSEHISVYQQKENERDVWALLNGKKDDFFIYDR 2 1 CGHLVYHFRLPYSFLTFPYVEEGIKIAYCENKCGNCPPT 0 0 FINLFQALKDEDVCENVSLAITEKTTEVSQPHPHHNHHHKHPGNSQLPENQQTGAPDAPQQPPPPGLHHHHKHQGQQREGHPDNCDMPESEGLQLSPHQKKLuRKRCINQLFCKVSKDSE LAPRSCCuHCRHLVFEKTGSAITCQCKENLPSLCSuQGLWAEENVIESuQuRLPPAAuQISQQLLKPTEVSTNuEuNNKADMuKuPAN* 0 >SEPP1_ornAna Ornithorhynchus anatinus (platypus) 0 MWQGLGLALALCLLPGGGAESQSASSHCKEAPRWQIRDQDPMLNSLGTVTVVALLQASuYLCILQASR 2 1 LEDLRVKLENEGYSNISYIIVNHQGMPSQLNHKTLKEKVSEHIPVYQQDEKQTDVWSTLKGNKDDFLIYDR 2 1 CGRLVYHLSLPYTFLSFSYVEDSIKTTYCEQNCGNCSYT 0 0 MPEAEEFCTNTSSAAKEKATEAPLPHNDRPHHHHHHHHHHGHKPHPSGTEQAPADPDGPLRSPAPQGLHKRLRPAGQPRQGQ GGSREAAEGRGEELPSPRKKAuRKGNASCQNQLLuDWHKRSGPAPSSuCuHCRHLLFGSKATATALuQCRDALPALCSuQGRQS GEDVIESuQuRSPLPAuPPAAQLPSPSPTDPNAAuKuENTAGMuKuPTR* 0 >SEPP1_galGal Gallus gallus (chicken) reqd traces tga-sel taa-stop 0 MWAGLGLALVLCLLPGGGTESQRCQEPPEWHIGEESPMLNARGSVAVVALLQASuYLCLLQASR 2 1 LEDLRVKLENEGLVNISYVVVNHQSPHSQKKFHLLQESVSDHITVYQQDDHQADVWTTLNGNKDDFLIYDR 2 1 CGRLVYHLGLPYSFLSFQYVEEAIKIAYCENNCGNCSYT 0 0 EPDIDNICENITKKEDENLAGIEPEPEPSGQHSHHHHQLHRHRHHHHHREGGRHSKNQNHQAPSESQRRHPHNGRRHRVFNHNRHDQ IGSHEQVETLPPGEGVENLPRVTKLuKKGKTICKNQLTuNWQTASDSTTSSuCCHCRHLLFEELGNSITuQ CRGALPNSCRuHGQLLAEDITESuQuRLLTAAuESAAGGGSETSDTuLuERAGNuAuKTN* 0 >SEPP1_xenTro Xenopus tropicalis (frog) frag 0 MWKGFALALALCLLPWGGAESQGHRKRCKEPPEWSIGDQNPMMQSAGKVTVVALLQASuSLCLLQASR 2 1 LEDLRLKLEKEKLVGISYVVVNHQGRQSRAKYDLLKSKVSEHIPVYQQEEYQPDVWSLLKGDKDDFFVYDR 2 1 CGRLVQHLELPYSLLHFPYVEEAIRIAYCEDKCGECEHK 0 0 ILDADVCKKPEEQQEQDKPVEEKVERPRHHRNHHRHHRPKHSGHRHRHHHSEDGQVAELDVLRSSAQANNRAGSQNGQGQ SVVQVVPQSEVLFVPQREADIPVLARQPuKKAKSuKKQYLuDWREEGGKAFNSuCuHuRQLSFEVTENEVAuHuQEALPSSC SuQELLSDSLPESuQuRLSAAAuHSESTGLPETKLESEPNAPuAuPQEAENuQuKELuRFLM* 0 >SEPP1_xenTro Xenopus laevis (frog) 0 MWKGFALALALCLLPWGGAESQGHRSRCKQPPDWSIGDQNPMIQSAGKVTVVALLQASuYLCLLQASR 2 1 LEDLRLKLEKEKLVGISYVVVNHQGRHSRAKYDLLKSKVSEHIPVYQQEENQPDVWSLLKGDKDDFFIYDR 2 1 CGRLVQHLELPYSLLHFPYVEEAVRIAYCGDKCGECEHK 0 0 IPDADVCKKPEEQPELEKPVEEKVERPRPHRNHHRHHRPKHSGHRHRHHNNEGGQAAEVDAFQTNNRAGSHNGQGQSVVPQSEVVFVPQ READVPVLALQPuKKAKSuKKQYLuEWREDAGKAFNSuCuHuRQLSFEIAQNEVTuRCQEALPASuQuQELLSDSLSESuQuRLSAAAuHSHS TGLPELDTESETNAPuAuPQEAENuQuKELuRFLM* 0 >SEPP1_danRer Danio rerio (zebrafish) 17 sel 0 MWKALSLTLALCLLVGCSAESETEGARCKLPPEWKVGDVEPMKNALGQVTVVAYLQASuLFCLEQASK 2 1 LNDLLLKLENQGYPNIAYMVVNNREERSQRLHHL LQERLLNITLYAQDLSQPDAWQAVNAEKDDILVYDR 2 1 CGRLTYHLSLPYTILSHPHVEEAIKHTYCDRICGECSLES 0 0 SAQLEECKKATEEVNKPVEEEPRQDHGHHEHGHHEHQGEAERHRHGHHHPHHHHHHHRGQQQVDVDQQVLSQVDFGQVAVETPMMKRPuAKHSRuKVQYSuQQGADSPVASu CuHuRQLFGGEGNGRVAGLuHCDEPLPASuPuQGLKEQDNHIKETuQuRPAPPAEuELSQPTuVuPAGDATuGuRKK* 0
SELPB
SELK: 32 vertebrate sequences
>SELK_homSap Homo sapiens (human) chr3 last coding bp and stop codon split off into 5th exon 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRSYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_panTro Pan troglodytes (chimp) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRSYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_ponPyg Pongo pygmaeus (orang_sumatran) 0 MVYISN 1 2 AQVLDSWSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDLKKRRSYGNSSDFRYDDDGRG 2 1 PPGNPPGRMGPINHLGGPSPPPMAGGuGR 2 1* 0 >SELK_macMul Macaca mulatta (rhesus) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRSYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_otoGar Otolemur garnettii (bushbaby) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRGYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLQGPSPPPMAGGuGR 2 1* 0 >SELK_micMur Microcebus murinus (mouse_lemur) 0 MSYISN 1 2 GQLLDSRSQSPWRLSLITDFFWRKPEFVVLF 2 1 FKTLLQQDVKKRRGCGNSSDSRYDDGRG 2 1 PPGNPFQRMGQINHLHGPSPPMAGGuGR 2 1* 0 >SELK_tupBel Tupaia belangeri (tree_shrew) 0 MVYISN 1 2 GRVSDSWSQSPWRLSLITDFFWGMAKFVVLS 2 1 FKTLLQQDVRKRKGYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRISHLRGPSPPPVAGGuGR 2 1* 0 >SELK_musMus Mus musculus (mouse) 0 MVYISN 1 2 GQVLDSRNQSPWRVSFLTDFFWGIAEFVVFF 2 1 FKTLLQQDVKKRRGYGSSSDSRYDDGRG 2 1 PPGNPPRRMGRISHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_ratNor Rattus norvegicus (rat) 0 MVYISN 1 2 GQVLDSRNQSPWRLSFITDFFWGIAEFVVFF 2 1 FKTLLQQDVKKRRGYGGSSDSRYDDGRG 2 1 PPGNPPRRMGRISHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_speTri Spermophilus tridecemlineatus (squirrel) 0 MVYISK 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVILF 2 1 FKTLLQQDVKKRRGYGNSSDSRYDDGRG 2 1 PPGNPPRRMGGINHLQGPSPPPMGGGuGR 2 1* 0 >SELK_cavPor Cavia porcellus (guinea_pig) 0 MVYISN 1 2 GQVLDNRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKGRGYRNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLQGPSPPPMAGGuGR 2 1 * 0 >SELK_oryCun Oryctolagus cuniculus (rabbit) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLL 2 1 FKTLLQQDVKRGRGYRNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_ochPri Ochotona princeps (pika) 0 MVYISN 1 2 GQVLDSRSQSPERLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKRRRDYRSSSDSRYDDGRG 2 1 LPGNPPRRMGRIYHLRCPSPPPPPGGGuGR 2 1* 0 >SELK_canFam Canis familiaris (dog) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRGYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_neoVis Neovison vison (mink) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRGYGSSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1* 0 >SELK_felCat Felis catus (cat) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVVLL 2 1 FQTLLQQDVKKRRGYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_equCab Equus caballus (horse) 0 MVYISN 1 2 GQVLDSRSQSPWRLSFITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRRGYGSSSDSRYDDGRG 2 1 PPGNPRRRMGRINHLHGPSPPPMAGGuGR 2 1 * 0 >SELK_myoLuc Myotis lucifugus (microbat) 0 MVYIEN 1 2 RQVLDSRSQSPwRLSLITDFFWGIAEFVVLF 2 1 FKTLLQKDMKKGRGYGNSSDSRYDDGRG 2 1 PPGNPPRRMGRIDHLRGPSPPPMAGGuGR 2 1* 0 >SELK_bosTau Bos taurus (cow) 0 MVYISN 1 2 GQVLDSRSQSPWRLSFITDFFWGIAEFVVLF 2 1 FRTLLQQDVKKRRGYGSSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLQGPNPPPMAGGuGR 2 1 * 0 >SELK_susScr Sus scrofa (pig) 0 MVYISN 1 2 GQVLDSRSQSPWRLSFITDFFWGIAEFVVLF 2 1 FRTLLQQDVKKRRGYGGSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPNPPPMAGGuGR 2 1 * 0 >SELK_dasNov Dasypus novemcinctus (armadillo) 0 MVYISN 1 2 GQVLDSRSQSPWRLSLITDFFWGIAEFVILL 2 1 FRTLLQQDVKKKRGYGSSSDSRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_loxAfr Loxodonta africana (elephant) 0 MVYISN 1 2 GQVLDSRSQSPWRLSFITDFFWGIAEFVVLF 2 1 FKTLLQQDVKKRGGYGSSSDFRYDDGRG 2 1 PPGNPPRRMGRINHLRGPSPPPMAGGuGR 2 1 * 0 >SELK_ornAna Ornithorhynchus anatinus (platypus) EUEMSW407EBWK3 454 0 MVYISN 1 2 GHVLNGQNRSLWSLSFIKDFFWGILDFIIMF 2 1 FKSMIHPNVKRGCRNSSSDSKYDDGRG 2 1 PPGYPRRGMGRINHSNGPSPPPMAGGGuGR 2 1 * 0 >SELK_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01DCGU7 454 0 MVYISN 1 2 GHVLNGQNRSPWSLSYIKDFFWGILDFIIMF 2 1 FKSMIHPNVKRGCRNSSSDSKYDDGRG 2 2 PPGYPRRGMGRINHSNGPNPPPMAGGuGR 2 1 * 0 >SELK_anoCar Anolis carolinensis (lizard) 0 MVYISN 1 2 GQVLDNQSRAPWSFSSITDFFWGIADFVVMF 2 1 FQSIIHPDLTRGSTSSSSSRYDDGRG 2 1 PPGLPRRRMGRISHFGGPSPPPMAGGuGR 2 1 * 0 >SELK_galGal Gallus gallus (chicken) 0 MVYISN 1 2 GQVLDNRSRAPWSLSAITDFFWSIADFVVMF 2 1 FQSIIQPDLRRRGYTSSSYLGQSDGRG 2 1 PPGNPRRRMGRINHWGGGPSPPPMAGGGuGR 2 1 * 0 >SELK_taeGut Taeniopygia guttata (finch) 0 MVYISN 1 2 GQVLDSQSRAPWRLSSITDFFWSIADFVVLF 2 1 FQSIIQPDLRRRGYTSSSYSGYHDRRG 2 1 PPANPRRRMGRINHWGGGPSPPPMAGGGuGR 2 1* 0 >SELK_xenTro Xenopus tropicalis (frog) 0 MVYISN 1 2 GQVLDGQSRSPWRLSFLTDMFWGITDFVVMF 2 1 FQSIIHPNVTRRGCQNSSSSTRYDDGRG 2 1 PPGHPRRMGRINHGSGPSAPPMAGGGGuGR 2 1 * 0 >SELK_oncMyk Oncorhynchus mykiss (trout) 0 MVYVAN 1 2 GQVLDNRSQSPWRMSFLTDLFWGAVEFIGLF 2 1 FQSLVQPDLTKRGNSGSSSTGYSDGRG 2 1 PPGPPGGRRRMGRINHGGGPSAPPMGGGGuGR 2 1 * 0 >SELK_salSal Salmo salar (salmon) 0 MVYVAN 1 2 GQVLDNRSQSPWRMSFLTDLFWGAVEFIGLF 2 1 FQSLVQPDLTKRGNSGSSSAGYSDGRG 2 1 PPGPPGGRRRMGRINHGGGPSAPPMGGGGuGR 2 1 * 0 >SELK_oryLap Oryzias latipes (medaka) BJ003636 tag confirmed 0 MVYVSN 1 2 GQVLDSRAQSPWRLSLLVDLFWDALEFFRLF 2 1 FKTMFHPDLTKDGNSASSRFSDGRG 2 1 PPGPPGGRRRIGRINHGAGPNAPPMGGGGuGR 2 1 * 0 >SELK_braFlo Branchiostoma floridae (amphioxus) tga confirmed 0 MVYVTG 1 2 GQMLENRSPWRLSIIPEIFWGFINFIVLF 2 1 FQTMYNPSLSKHGSDTPSSYSRGDGRG 2 1 PPPPPPRRRFGGVRRGGAPGPPPMAGGGuGR 2 1 * 0
Reference sets of vertebrate SECIS elements
SEPP2: 5 SECIS sequences
>SEPP2_SECIS_monDom Monodelphis domestica (opossum) chr2:9455773-9456962 COVE: 30 55 bp after stop codon ACGTGCCGCTGCCCCTCCCTCCCTCCAAGAATGACGCCCACAGTGAAACCCAGAGAACTGGTCCCTGTGGGCTGATGCCCCAGAGGGGAGGAGAGGC >SEPP2_SECIS_macEug Macropus eugenii (wallaby) SECIS COVE score: 26.38 trace ti|975557399 contains terminal exon CCTCATTCCTCTTCTCCATGGCATCAGCCCACCATGGCCGGTTCCCCGGGTTTCACTGTGGGCATCATTAATTGAGGGAGGGAAGGGCAATGGGCAAG >SEPP2_ornAna Ornithorhynchus anatinus (platypus)Ultra131:321101-348720 COVE: 34.28 no match to chicken TCCCTCGACTCCCGCTCCCGCCTCGCACTCATGACGTCCACGGTGTCAACCGGCCCGCCGGGCACCGTGGACTGACGCCGGTCGAGGCGGAGGGGT >SEPP2_ornAna Ornithorhynchus anatinus (platypus) Ultra131:321101-348720 COVE: 22.82 no match to chicken GGAATCAGGAACCCAGTAACATGAGGTCATCTTCGGAAGCCTGTGCCTAGAGGACCAAGATAATGGAAAAAGTGACGGACAAGGGTGTGTAGCTGG >SEPP2_tetNig Tetraodon nigroviridis (pufferfish) COVE: 17 GCTGGACCCAGGCTGCTGGTGGTCCCGTTGATGACGTCTGCGCTGGTAAACCTGCCTGCAGGAGCCTGTGGACCGACGTGTGTGGACCCACCGGCAG
SELI: 17 SECIS sequences
>SELI_SECIS_homSap Homo sapiens (human) COVE score: 21.61 UUUCACUGAA UGAAGUU UGUGCUUGA AUGAA GAGUGUAUCUUA AA CCCCCUUUUUUUGGA CAGGCUGCACUU GGAU AAAAUA GGCACCA CUGUGUUGAU >SELI_SECIS_panTro Pan troglodytes (chimp) COVE score: 21.61 uuucacugaa ugaaguu ugugcuuga augaa gaguguaucuua aa cccccuuuuuuugga caggcugcacuu ggau aaaaua ggcacca cuguguugau >SELI_SECIS_macMul Macaca mulatta (rhesus) COVE score: 21.25 uuucacugaa ugaaguu ugugcuuga augaa gaguguaucuua aa ccuccuuuuuuugga caggcugcacuu ggau aacaua ggcacca cuguguugau >SELI_SECIS_otoGar Otolemur garnettii (bushbaby) COVE score: 21.25 uuucacuaag ugaaguu ugugcuuga augaa gaguguaucuu aa acccuuuuuuuuggac agguugcacuu ggau aaaaua ggcacca uuguguugau >SELI_SECIS_musMus Mus musculus (mouse) COVE score: 24.62 uuccacugaa ugaaguu ugugcuuaa augaa gagugugucuu aa acccuuuuuuuuggac agguugcacuu ggau aaaaua ggcacca cuguguugau >SELI_SECIS_ratNor Rattus norvegicus (rat) COVE score: 24.62 uuccacugaa ugaaguu ugugcuuaa augaa gagugugucuu aa acccuuuuuuuuggac agguugcacuu ggau aacaua ggcaccg cuguguugau >SELI_SECIS_cavPor Cavia porcellus (guinea_pig) COVE score: 17.42 uuccagugaa ugaaguu ugugcuuga augaa gaguguaucuua aa cccuuuuuuuuuugga cagguugcacuu ggau aaaaua ggcacca cuguguugau >SELI_SECIS_oryCun Oryctolagus cuniculus (rabbit) COVE score: 19.47 ucuacugaau gaaguuu gugcuuga augaa gaguguaucuua aa cccuuuuuuuuugga cagguugcacuu ggau aaaau aggcac cacuguugau >SELI_SECIS_sorAra Sorex araneus (shrew) COVE score: COVE score: 8.13 loose uuccacugaa ugaaguu ugugcuuga augaa gaguguaucuu aa acccuuuauuuuguuuuuuugga cggauuacacuu ggau auaaua ggcacca uucuguugau >SELI_SECIS_eriEur Erinaceus europaeus (hedgehog) COVE score: 14.43 loose cacggaauga aguaugu gcuuga augaa gaguguaucuu aa acccuuuuuuuuuuuugga cagguugcacuu ggau aua auaggc accacucugu >SELI_SECIS_canFam Canis familiaris (dog) COVE score: 14.04 uuccacugaa ugaaguu ugugcucga augaa gaguguaucuua aa cccuuuuuuuuuugga uggauugcacuu ggau aaaaua ggcacca cuguguugau >SELI_SECIS_equCab Equus caballus (horse) COVE score: 19.57 uuucacugag ugaaguu ugugcucga augaa gaguguauucuu aa acccuuguuuuugga uggauugcacuu ggau aaaaua agcacca cuguguugau >SELI_SECIS_dasNov Dasypus novemcinctus (armadillo) COVE score: 17.76 loose cuacugaauu aaguuug ugcuuga augaa gaguguaucuu aa acccuuuguuuuuuugga cagguugcacuu ggau aaaa uaggca ccacuauguu >SELI_SECIS_loxAfr Loxodonta africana (elephant) COVE score: 25.81 uuccacugaa ugaaguu ugugcuuga augaa gaguguaucuu aa acccuuuuuuuuggac agguugcacuu ggau aaagua ggcacca cuguguugau >SELI_SECIS_monDom Monodelphis domestica (opossum) COVE score: 26.46 uucuacugaa ugcaauu ugugcuuga augaa gagugugucuu aa auccuuuauauggac aggcugcacuu ggag aga auaagca caaccauguu >SELI_SECIS_ornAna Ornithorhynchus anatinus (platypus) COVE score: 19.25 ucccagugaa ugaagcu ugugcuuga augaa gagugcaucuua aa cccauuuuuuuugga aaagcugcacuu ggag agaaag ggcacg acuguguuua >SELI_SECIS_anoCar Anolis carolinensis (lizard) COVE score: 22.02 uccccuuugu guguguc cuuugugcgugu augaa gagugcggccuc aa cccaggcgucuugga agggccgcaccc ggaa gaa acggagc acagcaaaga >SELI_SECIS_galGal Gallus gallus (chicken) COVE score: 24.62 uuuuauugag uuuauuu gugcuuaa augaa gagugcgcuuc aa acccagaccaggag agggcgcacuu ggag ugagc gagucaa accuugcucc
SELK: 19 SECIS sequences
>SELK_SECIS_homSap Homo sapiens (human) COVE score: 34.53 acaaggacug cucugug uccucacagauga augag gucaugcuggg aa uucccucugcaggga acuggccugac ugac augcaguuc cauaaa ugcagauguu >SELK_SECIS_panTro Pan troglodytes (chimp) COVE score: 34.53 acaaggacug cucugug uccucacagauga augag gucaugcuggg aa uucccucugcaggga acuggccugac ugac augcaguuc cauaaa ugcagauguu >SELK_SECIS_macMul Macaca mulatta (rhesus) COVE score: 36.14 acaaggacug cucugug uccucacagauga augag gucaugcuagg aa uucccucuacaggga acuggccugac ugac augcaguuc cauaaa ugcagauguu >SELK_SECIS_otoGar Otolemur garnettii (bushbaby) COVE score: 31.99 caaggauugc ucugugu cuucacagauga augag gucaggcuggg aa uucucucuucaggga acuggccugac ugac augcagu ucuauaa acgcacuuuu >SELK_SECIS_tupBel Tupaia belangeri (tree_shrew) COVE score: 36.65 acaaggauug cucugug uccccacagauga augag guuaugccggg aa uucccuccacaggga ucuggccugac ugau acgcaguuc uauaaa ugcacauguu >SELK_SECIS_musMus Mus musculus (mouse) COVE score: 31.73 acaaggauug cucugug uccccacagauga augag gucaugcuggg aa uucccucugcagga ucuagccugac ugau acgcaguuc uauaaa uguacauguu >SELK_SECIS_ratNor Rattus norvegicus (rat) COVE score: 33.02 acaaggacug cucugug uccucacagaaga augag gucaugcuggg aa cucccucugcagga ucuggccugac ugau gugcaguuc uauaaa uguacaugug >SELK_SECIS_cavPor Cavia porcellus (guinea_pig) COVE score: 33.72 cucuguguuc ucacaga uaa augag gucacgccagg aa uucucucagcaggga ucuggcuugac ugau acgcagu ucucua aaugcauaug >SELK_SECIS_oryCun Oryctolagus cuniculus (rabbit) COVE score: 38.80 accaggauug cucugug uccccacagauga augau gucaggcuggg aa uucccuccacaggga ucuggccugau ugag augcaguuc uauaaa ugcguauguu >SELK_SECIS_sorAra Sorex araneus (shrew) COVE score: 40.91 auaaggacug uucugug uccacacagauga augag gucaugcuggg aa uucccucuacgggga ucuggcaugac ugau augcag uucgaua aaugcacaug >SELK_SECIS_eriEur Erinaceus europaeus (hedgehog) COVE score: 37.30 acaaggauug cucugug uucucacagguga augag guuaugcuggg aa uucccuccaugggga ucuggcaugac ugau augcaguuc uauaaa ugcacauguu >SELK_SECIS_canFam Canis familiaris (dog) COVE score: 36.30 acaaggauug cucugug ccuucacagacgg augag guugugcuagg aa uucccuccccaggga ucuggcaugac ugac augcaguuc uauaaa ugcacauguu >SELK_SECIS_felCat Felis catus (cat) COVE score: 37.35 acgagaauug cucugug uccucacagacag augag gucgugcuggg aa uucccuccccaggga ucuggcaugac ugac augcaguuc uauaaa ugcacauguu >SELK_SECIS_bosTau Bos taurus (cow) COVE score: 39.16 cucugugucc ucacaga cga augag gucaugcuggg aa uucccuccgcaggga ucuggcaugac ugac augcagu ucuaua aaugcacguu >SELK_SECIS_dasNov Dasypus novemcinctus (armadillo) COVE score: 29.00 acaaggauug cucugug uccucacagauga augag gucauguuuggg aa uucccucugcaggg aucuggcaugac ugac uugcaguuc cauaaa ugcacauguu >SELK_SECIS_loxAfr Loxodonta africana (elephant) COVE score: 34.85 acaaagacug cucugug uccccacagacgg augag gcugugcuggg aa uucccucugcaggga ucuggcauggc ugac augcaguuc cauaaa ugcacauguu >SELK_SECIS_monDom Monodelphis domestica (opossum) COVE score: 21.75 aagaauugcu cugucua cacagauua augau guugugcuggg aa cucccaucuuacagga uccaguguaac ugau ugcaa uuguaua aaugcacaug >SELK_SECIS_ornAna Ornithorhynchus anatinus (platypus) COVE score: 33.68 aauaauugug cugugaa caagcagauua augau guuuugcuggg aa uuccuucaggga uccaguauaac ugau aaagc aauuaua uaaaggcaca >SELK_SECIS_anoCar Anolis carolinensis (lizard) COVE score: 33.87 aauucccugc ucugcca auuggcgggacc augau guuguccuggg aa uuccuuauucuggga uccagggcaac ugaa aagcaguuc uguuaa auuaaaugca >SELK_SECIS_galGal Gallus gallus (chicken) COVE score: 30.90 ugagaacugu ucugcaa uauaagcagauga augaa guuguacuggg aa cuccuucaagga uccaguguaac ugaa gugcagug uuauuaa auacauguuu
SEPW1: 13 SECIS sequences
>selW_SECIS_homSap Homo sapiens (human) agggaccttgacccagcccctctcagcagacgcttcatgataggaaggactgaaaagtcttgtggacacctggtctttccctgatgttctcgtggctgctgttgggggcagagattgacgcccccggtctttgcct >selW_SECIS_panTro Pan troglodytes (chimp) AGGGACCTTGACCCAGCCCCTCTCAGCAGACGCTTCATGATAGGAAGGACTGAAAAGTCTTGTGGACACCTGGTCTTTCCCTGATGTTCTtGTGGCTGCTGTTGGGGGCAGAGATTGACGCCCCCGGTCTTTGCCT >selW_SECIS_ponPyg Pongo pygmaeus (orang_sumatran) AGTCCAGGGACCTTGACCCAGCCCCTCTCAGCAGACGCTTCATGATAGGAAGGACTGAAAAATCTTGTGGACACCTGGTCTTTCCCTGATGTTCTCGTGGCTGCTGTTGGGGGCAGAGATTGACGCCCCTGGTCTTTGCCT >selW_SECIS_macMul Macaca mulatta (rhesus) AGcGACCTTGACCCAGCCCCTCTCAGCAGACGCTTCATGATAGGAAGGACTGAAAAGTCTTGTGGACgCCTGGTCTTTCCCTGATGTTCTCGTGGCTGCTGTTGGGGGCAGAGATTGACGCCgCtGGTCTTTGCCT >selW_SECIS_musMus Mus musculus (mouse) ACTGAAATGTCTTAGACTTGGCCCAGCCCCTCGTGGCAGACGCTTCATGATGGGAAGAACTGAAATGTCTCGTGGACGCCTGGTCTTTCCCTGATGTCCCTGCGACTGCCACGTAGGGGCAGAGACTGATGCCCCTGTGGGTGCCT >selW_SECIS_ ratNor Rattus norvegicus (rat) CCTGGCCGGCCTTTCTTGGCAGCCGCTTCATGACAGGAAGGACTGAAATGTCTCAAAGACCTGTGGTCTTTCTTCGATGTTCCTGCGGCCACCAAGTCAGGCCAGAGATGGATTCTGTGTGTGGGTGCCT >selW_SECIS_oryCun Oryctolagus cuniculus (rabbit) AGTAACCTTGACCCAGCCCCTTTCATGCCTCAGCCTCGTCTCCATAGGCTAAGACTGGAGAAATGAGTCCCCTGAAGAACTGAAACTGGGGGTAGAGGGTTGGTGTTTTAAGATGTGGATGAGCTGGTCTTTAC >selW_SECIS_canFam Canis familiaris (dog) CCAGtGACCTTGgCCCAGCCCCTCgtgGCAGACGCTTCATGATgGGAAGaACTGAAAtGTCTcGTGGACgCCTGGTCTTTCCCTGATGTccctgcgactgccacgtaGGGGCAGAGAcTGAtGCCCCtGGTCTTTGCCT >selW_SECIS_susScr Sus scrofa (pig) AGTAACCTTGACCCAGCCCCTTTCATGCCTCAGCCTCGTCTCCATAGGCTAAGACTGGAGAAGTCTTGTGGACGCCTGGTCTTTCCCTGATGTTCTCGTGGCTGCTGTTGGGGGCAGAGATGGATGAGCTGGTCTTTAC >selW_SECIS_borAnc Boreoeuthere ancestralis (ancestral) AGTCCAGCAACCTTGGCCCAGCCCCTCTCAGCAGATGCTTCATGACAGGAAGGACTGAAATGTCTTGTGGACGCCTGGTCTTTCCCTGATGTTCTTGTGGCTGCTGGTTGGGGCAGAGATTGACACCCCTGGTCTTTGCCT >selW_SECIS_dasNov Dasypus novemcinctus (armadillo) CCAGCAACCTCAGCCCAGCTGCCCTTGGCAGACGCTTCATGAGGGGAAGGACCTAAATGCGTCGTGGATGCCTGGTCTTTCCCTGATGCTCCTTCACCTGCCAGATGGGGCAGAGGTCATTGCCCCTGGTCTTGGCCT >selW_SECIS_loxAfr Loxodonta africana (elephant) GGGACCTTGGCCCAGCCCCTTTCAGCAGACACTTCATGACAGGAGGACTGAAATGTCTCCCAGACGCCTGGCTCTTTCCCTGAATCTGTCGGCTGCAGGACAGGGCAGCGGTTGACTCTCTCGTTTTTTGCAT >selW_SECIS_echTel Echinops telfairi (tenrec) AGGCCAGAGACCTTGGCCCAGTCCCTCCATGACAGGCAGAACTGAAATGTCCTCTGGACAAGTGGTCTTTTCCAGAAACCCCAGGGCTGCTGGGCCGGAGCCGAGGCTGACAACCCTGGTCTTTGCCT
DIO1: 29 SECIS sequences
>DIO1_SECIS_homSap Homo sapiens (human) COVE score: 29 ttttaactctgtgtctttacatatttgtttatgatggccacagcctaaagtacacacggctgtgacttgattcaaaagaaaatgttataag >DIO1_SECIS_ponPyg Pongo pygmaeus (orang_sumatran) COVE score: 29 ttttaactctgtgtctttacatatttgtttatgatggccacagcctaaagtacacacggctgtgacttgattcaaaagaaaatgttataag >DIO1_SECIS_macMul Macaca mulatta (rhesus) COVE score: 29 tttcaactctgtgtctttacatatttgtttatgatggccacagcctaaagtacacacggctgtgacttgattcaaaagaaaatgttataag >DIO1_SECIS_cavPor Cavia porcellus (guinea_pig) COVE score: 24 tgttaactctgcttcttttcatatttgttcatgacggtcacagtctaaagtacacacagctgtgacctgatttgaaagaaaatgttttaag >DIO1_SECIS_canFam Canis familiaris (dog) COVE score: - ttttaactctgcttcttttcatgtttgtctatgacggccacagcctaaagcacacacagctgtgacttgatttgaaagaaaatgttttaag >DIO1_SECIS_felCat Felis catus (cat) COVE score: - ttttaactctgcttcttttcacgtttgtctatgacggccacagtctaaagtgcacacagctgtgacttgacttgaacgaaaatgttttaag >DIO1_SECIS_bosTau Bos taurus (cow) COVE score: 28 ttttaactctgcctcttttcatatttgttcatgacggccacagcctaaagtacacacggctgtgacttgatttgaaagaaaatgttttaag >DIO1_SECIS_sorAra Sorex araneus (shrew) COVE score: 24 cggaaactcagcttctcttcatatttgtttatgacagccccagctgaaagtacacacagctgtggcttgattggaaagaaaatgttttaag >DIO1_SECIS_eriEur Erinaceus europaeus (hedgehog) COVE score: 26 tttaactctgctttcttctcatatttgcttatgatggtcacagcttaaagtatacacagctgtgacttgattggaaagaaaatattttaag >DIO1_SECIS_borAnc Boreoeuthere ancestralis (ancestral) COVE score: 29 ttttaactctgcttcttttcatatttgttcatgatggccacagcctaaagtacacacggctgtgacttgatttgaaagaaaatgttttaag >DIO1_SECIS_dasNov Dasypus novemcinctus (armadillo) COVE score: - ttttaactctgcttcttttcatatttgtttatgatggccacagtttaaagtacatacagctgtgacttgatatgaaaaagaaatattttaag >DIO1_SECIS_loxAfr Loxodonta africana (elephant) COVE score: - ttttaactctgcttcttttttcatgtatttatgatgggccacagcctaaagtgcacaacagctgtgacttgatttgaaaaacatctttaag >DIO1_SECIS_monDom Monodelphis domestica (opossum) COVE score: - tttccatcctgcttctacaaatatttatttatgacaatcacagcctaaagctcagggcagctgggattcgacgggagaaaaagtttgtaag >DIO1_SECIS_ornAna Ornithorhynchus anatinus (platypus) COVE score: 24 ccccggatccggttccgtgaatattggtttatgagggtcacagtgtaaagcgcatgcagctgtgacttgatctgagaaaatatttctgcggc >DIO2_SECIS_homSap Homo sapiens (human) 5,630 bp utr COVE score: 30 cagagatgtgcagagttgaccagtgtgcggatgataactactgacgaaagagtcatcgactcagttagtggttggatgtagtcacattagtttgcctctc >DIO2_SECIS_macMul Macaca mulatta (rhesus) COVE score: 30 cagagatgtgcagagttgaccagtgtgcggatgataactactgacgaaagagtcatcgactcagttagtggttggatgtagtcacattagtttgcctctc >DIO2_SECIS_musMus Mus musculus (mouse) COVE score: 29 cggagatgttcagagctcactggtgtgcgaatgataactactgacgaaagagctgtctgctcagtctgtggttggatgtagtcacacgagtctgcctttctgca >DIO2_SECIS_ratNor Rattus norvegicus (rat) COVE score: 28 ccgagatgttcggagctcactggtgtgcgaatgataactactgacgaaagagtcatctgctcagtctgtggttggatgtagtcacacgagtctgcctctccatc >DIO2_SECIS_canFam Canis familiaris (dog) COVE score: 27 ctgggatgtgcagaggtgaccagtgtgcgaatgataactactgatgaaagagtcactgactcagttagtggttggatacagtcacattagttttcctct >DIO2_SECIS_borAnc Boreoeuthere ancestralis (ancestral) COVE score: 30 ctgggatgtgcagaggtgaccagtgtgcaaatgataactactgatgaaagagtcattgactcagttagtggttggatgtagtcacattagtttgcctctc >DIO2_SECIS_dasNov Dasypus novemcinctus (armadillo) iodothyronine deiodinase type II ctgggaagttcagaggctaccagtgtgccaatgataactactgacgaaagaggcatcgactcagttagtggttggatgtagccacattagtttgcctctc >DIO3_SECIS_homSap Homo sapiens (human) COVE score: 31 ttgggtgcacaggagccccactgctgatgacgaactatctctaactggtcttgaccacgagctagttctgaattgcaggggcctcaaagcagca >DIO3_SECIS_macMul Macaca mulatta (rhesus) COVE score: 30 ttgggtgcacaggagccccactgctgatgacgaactgtctctaactggtcttgaccacgagctagttctgaattgcaggggcctcaaaacagca >DIO3_SECIS_musMus Mus musculus (mouse) COVE score: 26 ttgggtgcgctggagccctggctgctgatgacgaaccgcctctaactgggcttgaccacgggtcggctctgaattgcagagaggctcgaaacagc >DIO3_SECIS_ratNor Rattus norvegicus (rat) COVE score: 26 ttgggtgcgctggagccctggctgctgatgacgaaccgcctctaactgggcttgaccacgggtcggctctgaattgcagagaggctcgaaacagc >DIO3_SECIS_canFam Canis familiaris (dog) COVE score: 26 ttgggtgctggcgagccccactgctgatgacgagccgcctctaactggtcttgaccacgagctggttctgagttgcaggggggcttgcagcggc >DIO3_SECIS_bosTau Bos taurus (cow) COVE score: 30 ttgggtgctcacgagccccactgctgatgaagagctgtctctaactggcctcgaccacgagctggttctgatttgcaggaggctcgcagcagc >DIO3_SECIS_borAnc Boreoeuthere ancestralis (ancestral) COVE score: 27 ttgggtgctcaggagccccactgctgatgacgaactgtctctaactggtcttgaccacgagctggttctgaattgcagggggctcgcagcagca >DIO3_SECIS_loxAfr Loxodonta africana (elephant) COVE score: 22 ttcggtgcgctagagccccactgctgatgacgaactgtctctaactggtcttgaccacgagctgattccgaattgcagggaactcgcagcagc >DIO3_SECIS_echTel Echinops telfairi (tenrec) COVE score: - ttcggtgctctgcagccccactgctgatgacgaactgcctctcactggtcttgaccacgagctgcttctgaaatgcaggggactcgcagccgca
Basal selenoproteins: platypus (21), echidna (16), elephantshark (9), lamprey (11) and hagfish (7)
Outgroups are exceedingly important in determining ancestral characters along the evolutionary stem leading to placental mammals. The most important species are hagfish, lamprey, coelocanth/lungfish, and platypus/echidna. However only a fraction of the likely selenoprotein repertoire is available because of incomplete data.
These sequencs are current as of 6 May 2008. They derive from cdna at GenBank (both hagfish and lamprey selenoproteins were surprisingly well represented), at NCBI WGS contigs for cartilaginous fish and at the UCSC lamprey genome browser. Hagfish has no genome project underway so its transcripts have been intronated by homology. Platypus has both a genome assembly and a 454 transcrip project; echidna has only the latter. One interesting finding -- in addition to startling differences in degree of conservation of different selenoprotein -- is that SEPHS1 from both hagfish and lamprey have (ancestral) selenocysteine unlike mammals which have cysteine.
Summary of availablity by species: >DIO1_ornAna Ornithorhynchus anatinus (platypus) >DIO2_ornAna Ornithorhynchus anatinus (platypus) >DIO3_ornAna Ornithorhynchus anatinus (platypus) >GPX4_ornAna Ornithorhynchus anatinus (platypus) >GPX7_ornAna Ornithorhynchus anatinus (platypus) >MSRB1_ornAna Ornithorhynchus anatinus (platypus) >MSRB1_ornAna Ornithorhynchus anatinus (platypus) >MSRB3_ornAna Ornithorhynchus anatinus (platypus) >SELH_ornAna Ornithorhynchus anatinus (platypus) >SELI_ornAna Ornithorhynchus anatinus (platypus) >SELK_ornAna Ornithorhynchus anatinus (platypus) >SELM_ornAna Ornithorhynchus anatinus (platypus) >SELO_ornAna Ornithorhynchus anatinus (platypus) >SELS__ornAna Ornithorhynchus anatinus (platypus) >SELT_ornAna Ornithorhynchus anatinus (platypus) >SELU1_oan data Ornithorhynchus anatinus (platypus) >SEP15_ornAna Ornithorhynchus anatinus (platypus) >SEPHS1_ornAna Ornithorhynchus anatinus (platypus) >SEPHS2_ornAna Ornithorhynchus anatinus (platypus) >SEPP1_ornAna Ornithorhynchus anatinus (platypus) >SEPP2_ornAna Ornithorhynchus anatinus (platypus) >SEPW1_ornAna Ornithorhynchus anatinus (platypus) >DIO2_tacAcu Tachyglossus aculeatus (echidna) >GPX1_tacAcu Tachyglossus aculeatus (echidna) >GPX4_tacAcu Tachyglossus aculeatus (echidna) >GPX5_tacAcu Tachyglossus aculeatus (echidna) >GPX7_tacAcu Tachyglossus aculeatus (echidna) >MSRB1_tacAcu Tachyglossus aculeatus (echidna) >SELH_tacAcu Tachyglossus aculeatus (echidna) >SELK_tacAcu Tachyglossus aculeatus (echidna) >SELM__tacAcu Tachyglossus aculeatus (echidna) >SELO_tacAcu Tachyglossus aculeatus (echidna) >SELS_tacAcu Tachyglossus aculeatus (echidna) >SELT_tacAcu Tachyglossus aculeatus (echidna) >SELT_tacAcu Tachyglossus aculeatus (echidna) >SELU1_tacAcu Tachyglossus aculeatus (echidna) >SEP15_tacAcu Tachyglossus aculeatus (echidna) >SEPHS1_tacAcu Tachyglossus aculeatus (echidna) >SEPHS2_tacAcu Tachyglossus aculeatus (echidna) >SEPP1_tacAcu Tachyglossus aculeatus (echidna)
>DIO1_calMil Callorhinchus milii (elephantfish) >DIO2_calMil Callorhinchus milii (elephantfish) >DIO3_calMil Callorhinchus milii (elephantfish) >GPX2_calMil Callorhinchus milii (elephantfish) >SELO_calMil Callorhinchus milii (elephantfish) >SELU1_calMil Callorhinchus milii (elephantfish) frag >SEPHS1_calMil Callorhinchus milii (elephantfish) frag >SEPP2_calMil Callorhinchus milii (elephantfish) >SEPW2_calMil Callorhinchus milii (elephantfish) >DIO2a_petMar Petromyzon marinus (lamprey) frag >DIO2b_petMar Petromyzon marinus (lamprey) frag >GPX2_petMar Petromyzon marinus (lamprey) >MSRB3_petMar Petromyzon marinus (lamprey) >SELO_petMar Petromyzon marinus (lamprey) frag >SELS_petMar Petromyzon marinus (lamprey) >SELT_petMar Petromyzon marinus (lamprey) >SELU3_petMar Petromyzon marinus (lamprey) >SELW_petMar Petromyzon marinus (lamprey) >SEP15_petMar Petromyzon marinus (lamprey) >SEPHS1_petMar Petromyzon marinus (lamprey) >SEPN1_petMar Petromyzon marinus (lamprey) >GPX1_eptBur Eptatretus burgeri (hagfish) >GPX4_eptBur Eptatretus burgeri (hagfish) >SELT_eptBur Eptatretus burgeri (hagfish) >SELT_eptBur Eptatretus burgeri (hagfish) >SELW_eptBur Eptatretus burgeri (hagfish) >SEP15_eptBur Eptatretus burgeri (hagfish) >SEPHS1_eptBur Eptatretus burgeri (hagfish) GPX sites in lamprey browser needing evaluation: GPX Contig4536:10087-19433 GPX Contig4536:13614-13712 GPX Contig4536:17923-18132 GPX Contig33644:113-3872 GPX Contig41170:1909-3454 GPX Contig3803:603-6660 GPX Contig3036:20426-22172
These mostly fragmentary sequences are being moved into the respective gene collections.
>MSRB1_ornAna Ornithorhynchus anatinus (platypus)
DWKKKLTPEQYCVTRGKGTEP 0
0 PFSGIHLNNTERGMYHCLCCDMPLFS 2
1 SEKKFCSGTGWPSFLEAHGTQGTDESQTGILRRPDHSLGLARTEVVCKR 0
0 CEAHLGHVFDDGPPPTGQRFCINSVALTFKPS* 0
>MSRB3_ornAna Ornithorhynchus anatinus (platypus) (uc001ssm.1
0 MSAFNLLHLVTKSQPGSLQACGLPSGSRRDKRSCKVVFSQEELRKRLTPLQYHVTQEKGTESAFEGEFTHHKAPGTYKCVVCGTPLFKSETKFDS
GSGWPSFYDVIGSDAITLTDDFSYGMHRVETSCSQCGAHLGHIFEDGPRPTGKRYCINSASLSFAAVEENIDKENGSGDSPIQPGKTEL*
>GPX4_ornAna Ornithorhynchus anatinus (platypus) uc002lrg.1 EG341043
0 MSLFRLARLAKPLLLGGAVAVPALRRTMCASPDDWRCANSIYEFSAEDIDGKLVSLEKYRGKVCIITNVASKuGKTEVNYTQLVDLHAQYAGQGLRILGFP
CNQFGRQEPGTNSEIKEFAAGYNVKFDMFSKVCVNGDEAHPLWKWLKDQPKGKGTLGK* 0
>GPX7_ornAna Ornithorhynchus anatinus (platypus) uc001cue.1 LOC100090031 MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKY?
KGRVSLVVNVASECGFTDQHYRALQQLQKDLGPSHFNVLAFPCNQFGQQEPDGNKEIESFVRKTYGVSFPMFSKIAVSGAGANAAFKFLTESSGEEPTWNFWKYLVSPDGKVVNSWDSTVSVEEVRPQITALVRKLILLKREDL* 0
>SELO_ornAna Ornithorhynchus anatinus (platypus) uc003bjx.1
SRHADGRKVLRSSIREFLCSEAMFHLGIPTTRAGTCVTSESAVIRDVHYDGNPKYEKCAVVLRIASTFLRFGSFEIFKPRDEHTGRQGPSVGRNDIRIRMLDYVIGTFYPEIEEANADDTVRRNAAFFREVPGR
>SELS__ornAna Ornithorhynchus anatinus (platypus) MERQEESLSARPALETEGLRFL?
LFIVGSVLSAYGWYILFGCAVLYLIFQKLSGSLRVMRRRYSDTTGAAIDPEVVVKRQEALAASRLRMQEELNAQAEKYREKQKQLEEAKRRQKIEIWESMQEGKSYKGNSRLQPQQETDPGPSTSSVIPKPKPARKPLRGGYNPLSGEGGGTCSWRPGRRGPSSGGuG*
>DIO2_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01A7SZJ 454
GAECHLLDFASSERPLVINFGSATuPPQPAAGLQQAGEEFSTVADFLLVYI
>GPX1_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01BQVNH 454
NGEKAHPLFAFLRESLPTPSDDPTSLMNDPKFIIWSPVCRNDISWNFEKFLVGPDGVPLRYSRRFETINIKEDIAMLLDQ
>GPX4_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01DM9S9 454
LFRLARFAKPLLLGGAVAVPALRRTMCASPDDWRCANSIYDFSAEDIDGNSVSLEKYRGKVCIITNVASKuGKTEVNYTQLVDLHAQYVEQGLRILGFPCNQFGKQEPGTNSEIKEFAAGYNVKFDMFSKVCVNGDEAHPLWKWLKDQPKGKGTLGNAIKWNFTKFLIDREGQVVKRYGPMDEPRVIEKDLPCY
>GPX5_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01DBXSK 454
LLGDPTRLFWSPMKTHDIRWNFEKFLVGPDGVPVMRWYHRATVSTVK
>GPX7tacAcu EUPZL4S02GXFL4
QLQKDLGPSHFNVLAFPCNQFGQQEPDSNKEIESFVRKTYGVSFPMFSKIAVSG 163
>MSRB1_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01EKBYH 454
FCSFFGGEVFQNHFETGIYVCARCGYELFSSRSKFEHSSPWPAFTETIHPDSVAKREEPGRPGAFKVSCGKCGNGL
>SELH_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01B810Z 454
RALSLAAPHLPILLNPRQPRRNSFEVTLFGPDGTRTELWSGIKKGPPRRLKFPEPEMLADLLRSSLA
>SELK_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01DCGU7 454
VMVYISNGHVLNGQNRSPWSLSYIKDFFWGILDFIIMFFKSMIHPNVKRGCRNSSSDSKYDDGRGPPGYPRRGMGRINHSNGPNPPPMAGG
>SELM__tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01AWAS8 454
LNFRYEELERIPLSHMTRAEINQLVQDLGFYRKADRDAPVPPEFQQAPAK
>SELO_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01DJRM3 454
YGGHQFGTWAGQLGDGRAHLIGIYTNRHGEQWELQLKGSGRTPYSRNGDGRAVFRSSVREFLGSEAMHYLRIPTSRA
>SELS_tacAcu Tachyglossus aculeatus (echidna) EUEMSW404CHB0V 454
0 1
2 LRVMRQRYSDTTGAAI 1
2 DPEVVVKRQEALAASRLRMQEELNAQAEKYREKQKQ 0
0 LEEAKRRQKIEIWESMQEGKSYKGNSRLRPK 0
0 QETDPGPSTSSVIPKPKPARKPLRGG 1
2 SYNPLSGEGGGTCSWRPGRRGPSSGGuG* 0
>SELT_tacAcu Tachyglossus aculeatus (echidna) EUEMSW402BA71P 454
VFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS
>SELT_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01DXGYB 454
YRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFLLSNMIENQCMSTVAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLLNVHMDSIPHHRS
>SEPHS1_tacAcu Tachyglossus aculeatus (echidna) EUGXWLM01BJUY7 454
AEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVLVLTKPLGTQ
AKQQRSEVSFVIHNLPIIAKMAAITKACGNRFGLLQGTSSETSGGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNQTARIIDKPRIIEVTPRGAAAPPPDNNSSA
>SEPHS2tacAcu EUPZL4S02I1W5B
QRIRRGKLVVSREDVELAYQEAMFSMAMLNRTAAGLMHTFNAHAATDI
>SEPP1_tacAcu Tachyglossus aculeatus (echidna) EUEMSW408ERBZB 454
GELERHAPPGVPVYAQDGPDPDVWSILGGGKDDFLVYDRCGRLTFHIRLPFSFLHFPYVEAAVLFSHRHDFCGNCSYY
>MSRB3_petMar Petromyzon marinus (lamprey) cDNA FD728382 tga-sel taa-stop full
0 MSWAARLLGCAAVRAAGRAFGSVHARRHIALSTTLV 1
2 ASCKDTRTCRVNFAEEELRKKLSPLEFHVTQEKGTEP 2
1 AFTGKFAEHKGKGTYGCVVCQAPLFA 2
1 SQAKYDSGS 1
2 GWPSFYNIIRANAVSHSKDRSHGMHRTEVTCGQ 0
0 CGAHLGHVFDDGPPPTGKRFCINSASLNFNPSAEEEGGAEAVEEAPVKPELuGIGGIV* 0
>SELS_petMar Petromyzon marinus (lamprey) cDNA EB082976 39% identity homSap tga-sel taa-stop full
0 MDPRNEEPAVIRGVSDAVSELLARFGWPLLLFCALLYFTVRRAAPWLRWGRSSSSSTSISNPDLLMNMHSAMERSRIRMQQELDARAAEHQARVKQLEEERQKQ
KMESWERGRSLRPRRDPQSQQEDNSTPSTSLPRTERQRLRDNNYSPLSGGGGPTCLWRPGRRGPASGGGuG* 0
>SELW_petMar Petromyzon marinus (lamprey) cDNA FD700531 tga-sel tag-stop full
0 MPLKIHIVYCGAuGYRSRFHRLKDELETEFPGELEITGEGTPTQTGFLEVQIVGGKLLHSKANGDGFVDSDEKLQKIFSGVEKALKK* 0
>GPX4_eptBur Eptatretus burgeri (hagfish) BJ646422 tga-sel frag
0 GTM 0
0 ASNGEWQTAKNMFEFSAMDIDGNNVSLEKYR 2
1 GHVSIVVNVASKuGKTTVNYTQLSAMHAKYADSHGLRILAFPCNQFGKQ 0
0 EPGTDAEIKAFAAGYDVHFDLFSKIMVNGDDAHPLWKWMKSQRYGHGTLG 2
1 NAIKWNFTK 0
0 FLIDKEGQVVKRYGPIDDPV 0
0 VI
>GPX1_eptBur Eptatretus burgeri (hagfish) BJ648558 tga-sel tag-stop frag
0 SARGIAKSFYELSARNLAGuELVQFSKFRDKVVLIENVASLuGTTSRDFTQMNQLHQRLGVHGLVVLGFPCNQFGHQ 0
0 ENATNEELLQSLKYVRPGRGFEPNFPIFDKCEVNGANAHPLFTFLKEHLPLPSDNPTCFMSDCKSIIWSPVQRSDIAWNFEKFLIAPNGEPFRRYSKLYQTIDLEPDICKLLGL* 0
