User:Qing-Rong Liu

EDUCATION/TRAINING Peking University, Beijing, China BS 07/1981 Biochemistry

Peking University, Beijing, China MS 07/1984 Genetics

Baylor College of Medicine, Houston, Texas 01/1991 Pharmacology Ph.D.

Roche Institute of Molecular Biology, New Jersey Postdoctoral Molecular Biology 06/1993

Positions and Employment 1981-1982 Research Associate, China's Bureau of Oceanography, Shandong, China. 1984-1985 Lecturer, Department of Biology, Xiamen University, Fujian, China. 1991-1993 Postdoctoral Fellow, Roche Institute of Molecular Biology, Nutley, NJ 07110 1993-1994 Senior Molecular Neurobiologist, Sanofi Pharmaceuticals Inc. Bridgewater, NJ 08807 1994-1995 Assistant Professor, Department of Biochemical Sciences, University of Houston, TX 77024 1995-2002 Senior Staff Fellow. Molecular Neurobiology Branch, NIDA/NIH, Baltimore, MD 21224 2002-Present Staff Scientist. MNB and BNRB. NIDA/ NIH. Baltimore, MD 21224 Other Experience and Professional Memberships 1993- Society for Neuroscience (SFN) 1997- Chinese Biopharmaceutical Association-USA (SCBA) 1998- American Society of Human Genetics (ASHG) 1998- The Association of Chinese Geneticists in America (ACGA) 1999- Society of International Developmental Neuroscience (ISDN) 2011- The American Society for Biochemistry and Molecular Biology (ASBMB) Selected Peer-reviewed Publications 1. Airavaara M., Pletnikova O., Doyle M.E., Zhang Y.E., Troncoso J.C., and Liu Q.-R. (2011) Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer’s disease. J. Biol. Chem. 286, 45093-45102. 2. Xi Z.-X., Peng X.-Q., Li X., Song R., Zhang H., Liu Q.-R., Yang H.-J., Bi G.-H., Li JH., Gardner E.L. (2011) Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice. Nat. Neurosci. 14, 1160-1166. 3. Li C.Y., Zhang Y., Zhang P.W., Lu S.J., Li X.M., Yu Q., Zheng X., Du Q, Uhl G.R., Liu, Q.-R., and Wei L. (2010) A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions. PloS Comput. Biol. 6, e 1000734. 4. Liu Q.-R., Pan CH, Hishimoto A, Li CY, Xi ZX, Llorente-Berzal A, Viveros MP, Ishiguro H, Arinami T, Onaivi ES, Uhl GR. (2009) Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. 8, 519-530. 5. Han, J.C., Liu, Q.-R., Jones, M.P., Levinn, R.L., Menzie, C. M., BS, Kyra S. Jefferson-George, K.S., Adler-Wailes, D. C., Sanford, E. L., Lacbawan, F.L., Uhl, G.R., Rennert, O.M., and Yanovski, J.A. (2008) Brain-Derived Neurotrophic Factor in Human Energy Balance: WAGR Syndrome as a Model for BDNF Haploinsufficiency. New Engl. J. Med. 359, 918-927. 6. Liu, Q.-R., Walther, D., Drgon, T., Polesskaya, O., Lesnick, T.G., Strain, K.J., de Andrade, M., Bower, J.H., Maraganore, D.M., and Uhl, G.R. (2005) Human brain derived neurotrophic factor (BDNF) genes, splicing patterns and assessments of associations with substance abuse and Parkinson’s disease. Am J Med Genet B Neuropsychiatr Genet. 134B, 93-103. 7. Chan, W-Y., Liu, Q.-R., Borjigin, J., Busch, H., Rennert, O.M., Tease, L.A., and Chan, P.K. (1989) Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth. Biochemistry, 28, 1033-1039. 8. Liu, Q.-R., Nelson, H., Mandiyan, S., Lopez-Corcuera, B., and Nelson, N. (1992) Cloning and expression of a glycine transporter from mouse brain. FEBS Lett. 305, 110-114. 9. Lopez-Corcuera, B., Liu, Q.-R., Mandiyan, S., Nelson, H., and Nelson, N. (1992) Expression of a mouse brain cDNA encoding novel GABA transporter. J. Biol. Chem. 267, 17491-17493. 10. Liu, Q.-R., Lopez-Corcuera, B., Mandiyan, S., Nelson, H., and Nelson, N. (1993) Molecular characterization of four pharmacologically distinct -aminobutyric acid transporters in mouse brain. J. Biol. Chem. 268, 2106-2112. 11. Liu, Q.-R., Lopez-Corcuera, B., Mandiyan, S., Nelson, H., and Nelson, N. (1993) Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structure features. J. Biol. Chem. 268, 22802-22808. 12. Liu, Q.-R., Zhang, P. W., Zhen, Q. X., Wang, X. B., Walther, D., and Uhl, G. R. (2002) KEPI: A PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. J. Biol. Chem. 277, 13312-13320. 13. Liu, Q.-R., Zhang, P. W., Lin Z., Li, Q. F., Woods A. S., Troncoso J, and Uhl, G. R. (2004) GBPI, a novel gastrointestinal- and brain-specific PP1 Inhibitory protein, is activated by PKC and inactivated by PKA. Biochem. J. 377, 171-181. 14. Liu, Q.-R., Drgon, T., Walther, D., Johnson, C., Poleskaya, O., Hess, J., and Uhl, G.R. (2005) Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. Proc. Natl. Acac. Sci. U. S. A. 102, 11864-11869. 15. Liu, Q.-R., Drgon, T., Johnson, C., Walther, D., Hess J., and Uhl, G.R. (2006) Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. Am J Med Genet B Neuropsychiatr Genet. 141, 918-925. 16. Liu, Q.-R., Lu, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., and Uhl, G.R. (2006) Rodent BDNF genes, novel promoters, novel splice variants and regulation by cocaine. Brain Res. 1067, 1-12. 17. Hishimoto, A., Liu, Q.-R., Drgon, T., Pletnikova, O., Walther, D., Zhu, X.-G. Troncoso, J.C., and Uhl, G.R. (2007) Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum. Mol. Genet. 16, 2880-2891. 18. Onaivi, E.S., Benno, R. Halpern, T. Mehanovic, M. Schanz, N. Sanders, C. Ishiguro, H., Liu, Q.-R., Berzal, A. L. Viveros, M. P. and Ali, S. F. (2011) Consequences of cannabinoid and monoaminergic system disruption in a mouse model of Autism spectrum disorders. Current Neuropharmacology 9, 209-214.